A two-dimensional material for the medical wound area treatment is disclosed. A non-woven fabric consists of resorbable polymer filaments and collagen particles which have a particle size I >80 μm and are disposed on and/or in the non-woven fabric.

Dressings which may be useful in disrupting and/or preventing biofilm formation in a wound upon application are described, where the dressings of the present technology include a co-polymer of polyvinylpyrrolidone (PVP) and citric acid. Also disclosed herein methods employing such dressings as well as kits including such dressings.

The present invention is directed to medical devices having a first porous substrate layer with at least a surface coating thereon of a first co-reactive component and a second substrate layer with at least a surface coating layer of a second co-reactive component that reacts with the first co-reactive component, and a removable barrier layer positioned between the first substrate layer and second substrate layer and in contact with said first substrate layer and said second substrate layer.

An antimicrobial composition may comprise a surfactant. The antimicrobial composition may include about 30 μg/ml to about 1,000 μg/ml of the surfactant, by volume of the antimicrobial composition. The surfactant may comprise a docusate salt such as docusate sodium. The antimicrobial composition may comprise an antimicrobial agent. The antimicrobial composition may include from about 0.01% to about 10% of the antimicrobial agent, by weight of the antimicrobial composition. The antimicrobial agent may comprise polyhexanide (PHMB). In some embodiments, the antimicrobial composition may comprise a matrix-forming material. The antimicrobial composition may include at least 90% of the matrix-forming material, by weight of the antimicrobial composition. The matrix-forming material may comprise collagen, oxidized regenerated cellulose, alginate, carboxymethylcellulose, or combinations thereof.

The present disclosure provides a recombinant collagen and a recombinant collagen sponge material. The recombinant collagen comprises: (a) a protein composed of the amino acid sequence represented by SEQ ID NO: 2; and/or (b) a protein which has the same function as (a) and is derived from (a) by substitution, deletion and/or addition of one or more amino acids in SEQ ID NO:2. The recombinant collagen sponge material is obtained by sequential physical cross-linking and chemical cross-linking of the recombinant collagen. The recombinant collagen sponge material according to the present disclosure is capable of hemostasis, wound surface repair, moisture absorption and platelet aggregation, and has high moisture absorption, a significant hemostatic effect and good biocompatibility, assuming great clinical significance in the field of surgery.

Methods and compositions for reducing a ratio of collagen III to collagen I in wounded skin, treating wounds and accelerating healing is provided with a surfactant polymer dressing comprising FL2 siRNA, collagen and a poloxamer.

Disclosed is an absorbent article having, on its skin contact side, a sheet 2 having a region where, when rubbed under the conditions below, a friction coefficient or a mean deviation of the friction coefficient decreases by 5% or more or 15% or more, respectively, compared to before the rubbing. The absorbent article has a longitudinal direction X corresponding to the front-to-back direction of a wearer and a lateral direction Y. Conditions: A wet collagen film is reciprocated 10 times on the sheet in the longitudinal direction of the sheet under a load of 3.0 kPa; and the wet collagen film has a water content of 100 to 150 mass % relative to the dry weight thereof and is prepared by immersing a collagen film (EDCOL-R, available from PRIRO) cut out into a square of 10 cm in ion-exchanged water for 1 minute, taking out the collagen film, and removing excess water.

A dressing for treating a tissue site with negative pressure may include a bioresorbable manifold layer, which may include a first surface, a second surface opposite the first surface, a thickness. The bioresorbable manifold layer may include a plurality of sacrificial zones configured to degrade upon placement of the bioresorbable manifold layer with respect to the tissue site and application of negative pressure to the bioresorbable manifold layer so as to allow communication of negative pressure between the first surface and the second surface. The bioresorbable manifold layer may include a bioresorbable manifolding structure formed from a first bioresorbable composition and comprising a plurality of apertures corresponding to each of the plurality of sacrificial zones. The bioresorbable manifold layer may also include a second bioresorbable composition disposed within each of the plurality of apertures to form the sacrificial zones.

Dressings are provided herein having a manifold and a biopolymer layer. The configuration and/or compressibility of the manifold and the biopolymer layer can allow for reduced tissue ingrowth and promote wound healing. Methods of making and using the dressings are also provided herein.

Wound dressing compositions comprising of a bioresorbable sponge encapsulated within a polysaccharide envelope. The bioresorbable sponge is preferably comprised of collagen and oxidised regenerated cellulose. The outer polysaccharide envelope is preferably comprised of chitosan. The outer polysaccharide envelope functions to modulate the rate at which the bioresorbable sponge breaks down within a wound.