The present disclosure describes a wound dressing that incorporates a biopolymer scaffold, such as a keratin-based scaffold, into collagen-based materials to increase the mechanical strength of the wound dressing. The biopolymers can increase retention times in the wound environment so that the wound dressing may serve not as a catalyst for progressing beyond the inflammatory phase of wound healing. The longer retention times also enable the wound dressing to server as a structural scaffold for tissue integration.

The invention describes a method for the production of a biodegradable superabsorbent composite polymer material, characterized by high absorbency under load. The invention also describes novel composite material made of styrene maleic acid copolymer preferably in salt form and a biopolymer, coated with biodegradable coating agents and crosslinked.

A wound care bandage for treating a wound is provided. The bandage includes an SIS layer to be placed on the wound surface and a cover to be placed over the wound. The bandage further includes a structure to provide a vacuum space. A method for promoting wound healing is further provided. The method includes applying the above-mentioned wound care bandage to the wound and creating a vacuum in the vacuum space to draw blood controllably from the wound into the SIS layer.

A process for the extraction of collagen from collagen-containing matter, wherein the process comprises; incubating the collagen-containing matter in an acidic solution to form an incubant, then diafiltrating the incubant to substantially purify solubilised collagen within the incubant, thereby forming a retentate, then separating the soluble and insoluble matter of the retentate to remove the remaining insoluble matter, wherein the soluble matter is a substantially pure collagen solution.

The present invention relates to a method for producing a wound dressing on the basis of phospholipid-containing nanodispersions.

Disclosed is a wound treatment that includes collagen and a gelatin-reducing agent. Also disclosed is a wound dressing including a substrate, collagen, and a gelatin-reducing agent. The collagen and gelatin-reducing agent may be present in any suitable a weight ratio relative to one another, such as a weight ratio of about 0.25:1 to about 4:1 with respect to one another. Also disclosed is a method for promoting wound healing including administering collagen and a gelatin-reducing agent to a wound in need of treatment.

A cell therapy structure and method, including a matrix of fibers of a proteinaceous material and an electrically conductive material. The aligned fibers are spun from a combination the electrically conductive material, such as carbon nanotubes, and a fibroin material or a collagen material. A method of tissue engineering includes seeding a cell culture on a matrix of electrically conductive protein fibers, applying an electric current to the matrix to stimulate the cell culture, and applying the simulated cell culture to a tissue.

The present invention is directed to hemostatic sealants having a compressed porous substrate, an electrophilic group containing component that is not gelatin or collagen, a nucleophilic group containing component, and a buffering agent. The present invention also relates to method for manufacture and use of such sealants to seal and/or achieve hemostasis.

A bioactive collagen biomaterial according to the invention that is biocompatible with cells and tissues and distinguished by containing certain cryptic and non-cryptic peptide constituents to stimulate cellular responses and further made to incorporate a variety of agents to provide a desired characteristic, such as antimicrobial properties. The bioactive collagen biomaterial can be provided as a variety of configurations and as various matrices and devices for use in medical applications such as in biotechnology, basic research, tissue engineering and in wound repair as a wound dressing or cell/tissue scaffold.

Wound treatment materials can have at least two perforated biomatrix layers which are interconnected. Methods for preparing such wound treatment materials include the application of adhesives. Treatment of exuding wounds, and vacuum-assisted wound treatment therapy, can be carried out with the wound treatment materials.