A method of implanting a graft onto a proximal humerus includes securing a first suture anchor to a first portion of the proximal humerus and securing a second suture anchor to a second portion of the proximal humerus. The first suture anchor includes a first suture and the second suture anchor includes a second suture. The graft is inserted over the proximal humerus. The method further includes positioning the graft relative to the proximal humerus such that a lateral portion of the graft is oriented over a greater tuberosity of the proximal humerus and a medial portion of the graft is oriented over the medial greater tuberosity. The graft is secured to the proximal humerus via the first suture member and the second suture member. The method may also include securing the graft anteriorly to the subscapularis and/or posteriorly to the infraspinatus.

Treatment systems and methods are disclosed that may be used to strengthen cartilage. The disclosed subject matter includes description of this advantage and associated experimental results. The systems and methods employ ultrafast laser-based treatment to induce crosslinks into the collagen network of the tissue media without the addition of a chemical agent. The system and related methods may also be used for other purposes discussed herein.

The present invention relates to the technical field of silk scaffolds, and in particular, to a silk/pet mix-woven scaffold and a preparation method and use thereof. The silk/PET mix-woven scaffold is formed by weaving silk and PET fibers. Sericin of the silk is removed. The silk and the PET fibers are mixed and knitted. The PET fibers provide reliable fixation in an early stage to maintain the stability of mechanical properties, and the silk degrades gradually in a later stage to promote the growth of new tissues to achieve the integration of the scaffold and the body. When the scaffold is used for artificial tendon/ligament recovery, its overall performance is better than that of pure silk or pure PET fiber scaffolds, and the scaffold has excellent clinical transformation potential.

The present invention provides for an implantable medical device comprising a hybrid composite material including a first biological component such as an acellular tissue matrix and a second non-biological component for strengthening the device after implantation.

The present invention generally relates to a stem cell concentrate isolated from a mammalian vascularized adipose tissue, biopharmaceuticals containing such concentrate and use thereof in therapies for treating diseases in mammals.

A tendon repair implant for treatment of a partial thickness tear in the supraspinatus tendon of the shoulder is provided. The implant may incorporate features of rapid deployment and fixation by an arthroscopic means approach that compliment current procedures; tensile properties that result in desired sharing of anatomical load between the implant and native tendon during rehabilitation; selected porosity and longitudinal pathways for tissue in-growth; sufficient cyclic straining of the implant in the longitudinal direction to promote remodeling of new tissue to tendon-like tissue; and, may include a bioresorbable construction to provide transfer of additional load to new tendon-like tissue and native tendon over time.

The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.

The present disclosure describes methods of treating an injury in a subject using placental tissue streamers, engineered tissue placental tissue hybrids, suture placental tissue hybrids, placental tissue patch hybrids, and tissue hybrids, and the use of these compositions to repair, treat, or support an injury or degenerative process in a subject.

The present application is directed to the field of surgical implants useful in orthopedic surgery. In one aspect, the present application provides a novel, preshaped allograft or xenograft bone tendon (BT) or bone tendon bone graft (BTB) having at least a portion of the tendon that is wider than the bone blocks. Such preshaped grafts allow for more efficacious surgeries and reduced surgical time.

An improved method of making, manufacturing and/or producing engineered orthopedic soft tissue including cartilage, meniscus, annulus fibrosus, and tendon/ligaments which results in engineered soft tissue in which the fibers are aligned the same or nearly the same as naturally occurring tissue. The present invention also includes molds and other apparatus for carrying out the methods of the invention and kits.