The present invention refers to a system and method for connecting a concentrate container with a blood treatment device with improved hygiene. Furthermore, the invention refers to a container and blood treatment device to be used in a method according to the present invention.

The present invention refers to a system and method for connecting a concentrate container with a blood treatment device with improved hygiene. Furthermore, the invention refers to a container and blood treatment device to be used in a method according to the present invention.

An extracorporeal and drug delivery system includes (i) a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including (a) an effluent pump for pumping effluent from the blood filter at an effluent flowrate, and at least one of (b) a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flowrate, (c) a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or (d) a postdilution pump for pumping replacement fluid into the venous line at a postdilution flowrate; (ii) an infusion pump operable to deliver an intravenous (IV) drug to the patient at an IV drug flowrate; and (iii) a coordinating logic implementor configured to adjust the IV drug flowrate based on an amount of the IV drug removed via the effluent flowrate.

A system and method for connecting a concentrate container with a blood treatment device with improved hygiene. Furthermore, a container and blood treatment device useful with the system and method are also provided.

A blood purification device includes a first water removal amount calculation unit that calculates a water removal amount based on a flow rate in a dialysate supply flow path detected by the first supply-side flow meter and a flow rate in a waste liquid discharge flow path detected by a first discharge-side flow meter, a second water removal amount calculation unit that calculates a water removal amount based on a flow rate in the dialysate supply flow path detected by a second supply-side flow meter and a flow rate in a waste liquid discharge flow path detected by a second discharge-side flow meter, or calculates a theoretical water removal amount based on a target water removal rate and treatment time, and a determination unit that determines a detection defect based on a difference between the water removal amount calculated by the first and second water removal amount calculation units.

An extracorporeal and drug delivery system includes a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including an effluent pump for pumping effluent from the blood filter, and at least one of a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flowrate, a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or a postdilution pump for pumping replacement fluid into the venous line at a postdilution flowrate; an infusion pump operable to deliver an intravenous (IV) drug to the patient; and a coordinating logic implementor configured to determine if a formulation adjustment should be made to the IV drug when a constituent of the IV drug exists in the dialysis fluid, the predilution replacement fluid, and/or the postdilution replacement fluid.

This invention relates to a dialysis apparatus which ultra-filters blood and to a related method of ultra-filtering blood ex-vivo. More preferably the invention relates to haemodiafiltration using protein-losing membranes and a secondary ultrafiltration and partial re-infusion of haemodiafiltrate for increasing extraction of middle molecules and protein bound uraemic toxins and reducing albumin loss.

A system includes a fluid source storing a fluid and a fluid line coupled to the fluid source and configured to pass the fluid therethrough. The system includes a bubble detector coupled to the fluid line downstream of the fluid source, the bubble detector configured to detect bubbles present in the fluid and to generate a bubble detection signal. The system also includes a valve coupled to the fluid line downstream of the fluid source, the valve configured to switch between a first configuration and a second configuration, where in the first configuration the valve directs the fluid through the fluid line and in the second configuration the valve directs the fluid through a drain line. The system further includes a controller coupled to the bubble detector and the valve, the controller configured to receive the bubble detection signal and to control the valve based on the bubble detection signal.

A microdialysis system includes: an input device, first and second connecting pipelines and a flow feedback device that includes a connecting needle, a liquid collecting tank, a calibration weighing module, and a flow feedback control display module; the weighing module weighs the liquid in the liquid collecting tank regularly according to conditions and a program set in the display module and transmits a measured liquid weighing value to the display module; the display module performs a difference operation between the current liquid weighing value and the previous liquid weighing value to obtain a weighing sampling difference value, compares the weighing sampling difference value with a preset value to monitor whether the connecting needle outputs liquid normally, and further feeds back a flow state of fluid in the first and second connecting pipelines. In the microdialysis system, the flow state of each connecting pipeline is monitored by weighing the collected liquid.