Dialysis devices include a frame defined by a plurality of sidewalls that are impermeable to a sample being dialyzed, a pair of dialysis membranes that are each associated with an opposing face of the plurality of sidewalls such that the plurality of sidewalls and the pair of dialysis membranes define a sample chamber, an outer shell surrounding at least a portion of the pair of dialysis membranes, and a cap selectively associated with the sample chamber. The cap can be selectively associated with the sample chamber via an attachment mechanism that is configured to provide aural and/or haptic feedback when the cap forms a tight association with the sample chamber. The cap can be a sensor cap having one or more probes for measuring at least one property of fluid inside and/or outside the sample chamber and a transmitter for transmitting data captured at the probe(s) to a destination device.

A fluid sampling or infusion device for an extracorporeal blood treatment apparatus comprises: a protective body (29) having a first aperture (30) and a second aperture (31) and comprising a connecting device (28) configured to connect, optionally in removable manner, the protective body (29) to a sampling or infusion site (20) of the extracorporeal blood treatment apparatus (1); a needle assembly (33) comprising a first end (34) connected or connectable, optionally in removable manner, to a syringe (22) and a needle (35) protruding from a second end opposite the first end (34). The needle assembly (33) is movable inside the protective body (29) between a first position and a second position. In the first position the needle (35) is completely enclosed by the protective body (29) and in the second position the needle (35) protrudes from the second aperture (31) to pierce the sampling or infusion site (20).

An aspect of the disclosure relates to a dialysate regenerator, including: a purification means; at least one reversible retainer including an ion reservoir; a dialysate flow path including a dialysate inlet for receiving a dialysate, a dialysate outlet for dispensing the dialysate, the purification means and the at least one reversible retainer: a pump connected to the dialysate flow path and configured to generate a flow of the dialysate from the dialysate inlet via the reversible retainer and the purification means to the dialysate outlet, wherein a direction of the dialysate flow path through the reversible retainer is reversible.

A renal failure blood therapy system includes a renal failure blood therapy machine, concentration levels for each of a plurality of solutes removed from a patient's blood at each of the multiple times, a display device configured to display for selection at least one removed blood solute from the plurality of removed blood solutes, and a device programmed to (i) estimate at least one renal failure blood therapy patient parameter using the determined concentration levels for the at least one selected removed blood solute, (ii) determine a plurality of acceptable renal failure blood therapy treatments that meet a predetermined removed blood solute clearance for the at least one selected removed blood solute using the at least one renal failure blood therapy patient parameter, and (iii) enable selection of at least one of the plurality of acceptable renal failure blood therapy treatments for operation at the renal failure blood therapy machine.

Dialysis devices include a frame defined by a plurality of sidewalls that are impermeable to a sample being dialyzed, a pair of dialysis membranes that are each associated with an opposing face of the plurality of sidewalls such that the plurality of sidewalls and the pair of dialysis membranes define a sample chamber, an outer shell surrounding at least a portion of the pair of dialysis membranes, and a cap selectively associated with the sample chamber. The cap can be selectively associated with the sample chamber via an attachment mechanism that is configured to provide aural and/or haptic feedback when the cap forms a tight association with the sample chamber. The cap can be a sensor cap having one or more probes for measuring at least one property of fluid inside and/or outside the sample chamber and a transmitter for transmitting data captured at the probe(s) to a destination device.

A processor of a medical device configured to communicate with a remote server can be programmed to protect the medical device from exposure to unauthorized or malicious software. A system or method to implement this form of protection can include, for example, at least one processor on the medical device, a control software module that controls the operation of the medical device and is executable on the processor, a data management module that manages data flow to and from the control software module from sources external to the medical device, and an agent module that has access to a limited number of designated memory locations in the medical device. In addition, a hemodialysis apparatus can be configured to operate in conjunction with an apparatus for providing purified water from a source such as a municipal water supply or a well. A system for controlling delivery of purified water to the hemodialysis apparatus can comprise a therapy controller of the hemodialysis apparatus configured to communicate with a controller of a water purification device, and a user interface controller of the hemodialysis apparatus configured to communicate with the therapy controller, and to send data to and receive data from a user interface.

Hemodialysis and similar dialysis systems including a variety of systems and methods that make hemodialysis more efficient, easier, and/or more affordable, and include new fluid circuits for fluid flow in hemodialysis systems and a blood pump. The blood pump is configured to pump blood to a dialyzer of a hemodialysis apparatus and comprises a pneumatically actuated or controlled reciprocating diaphragm pump. The diaphragm of the pump comprises a flexible membrane formed or molded to conform to a curved inner wall of a pumping chamber or control chamber of the pump, and the diaphragm is pre-formed or molded to have a control side taking a convex shape, so that any elastic tension on the diaphragm is minimized when fully extended into a control chamber of the pump.

Dialysis is enhanced by using nanoclay sorbents to better absorb body wastes in a flow-through system. The nanoclay sorbents, using montmorillonite, bentonite, and other clays, absorb significantly more ammonium, phosphate, and creatinine, and the like, than conventional sorbents. The montmorillonite, the bentonite, and the other clays may be used in wearable systems, in which a dialysis fluid is circulated through a filter with the nanoclay sorbents. Waste products are absorbed by the montmorillonite, the bentonite, and the other clays and the dialysis fluid is recycled to a patient's peritoneum. Using an ion-exchange capability of the montmorillonite, the bentonite, and the other clays, waste ions in the dialysis fluid are replaced with desirable ions, such as calcium, magnesium, and bicarbonate. The nanoclay sorbents are also useful for refreshing a dialysis fluid used in hemodialysis and thus reducing a quantity of the dialysis fluid needed for the hemodialysis.

A renal failure blood therapy system includes a renal failure blood therapy machine, concentration levels for each of a plurality of solutes removed from a patient's blood at each of the multiple times, a display device configured to display for selection at least one removed blood solute from the plurality of removed blood solutes, and a device programmed to (i) estimate at least one renal failure blood therapy patient parameter using the determined concentration levels for the at least one selected removed blood solute, (ii) determine a plurality of acceptable renal failure blood therapy treatments that meet a predetermined removed blood solute clearance for the at least one selected removed blood solute using the at least one renal failure blood therapy patient parameter, and (iii) enable selection of at least one of the plurality of acceptable renal failure blood therapy treatments for operation at the renal failure blood therapy machine.

Dialysis is enhanced by using nanoclay sorbents to better absorb body wastes in a flow-through system. The nanoclay sorbents, using montmorillonite, bentonite, and other clays, absorb significantly more ammonium, phosphate, and creatinine, and the like, than conventional sorbents. The montmorillonite, the bentonite, and the other clays may be used in wearable systems, in which a dialysis fluid is circulated through a filter with the nanoclay sorbents. Waste products are absorbed by the montmorillonite, the bentonite, and the other clays and the dialysis fluid is recycled to a patient's peritoneum. Using an ion-exchange capability of the montmorillonite, the bentonite, and the other clays, waste ions in the dialysis fluid are replaced with desirable ions, such as calcium, magnesium, and bicarbonate. The nanoclay sorbents are also useful for refreshing a dialysis fluid used in hemodialysis and thus reducing a quantity of the dialysis fluid needed for the hemodialysis.