This disclosure relates to medical fluid sensors and related systems and methods. In some aspects, a circuit includes a radio frequency coil tuned to at least one frequency and at least one switching circuit directly connected to the radio frequency coil. The radio frequency coil is characterized by a high impedance.

A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in fluid communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood in a blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

A renal failure blood therapy system includes a renal failure blood therapy machine, concentration levels for each of a plurality of solutes removed from a patient's blood at each of the multiple times, a display device configured to display for selection at least one removed blood solute from the plurality of removed blood solutes, and a device programmed to (i) estimate at least one renal failure blood therapy patient parameter using the determined concentration levels for the at least one selected removed blood solute, (ii) determine a plurality of acceptable renal failure blood therapy treatments that meet a predetermined removed blood solute clearance for the at least one selected removed blood solute using the at least one renal failure blood therapy patient parameter, and (iii) enable selection of at least one of the plurality of acceptable renal failure blood therapy treatments for operation at the renal failure blood therapy machine.

This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a method includes using a medical fluid pump of a medical fluid pumping machine, such as a hemodialysis machine, to deliver medical fluid to a first portion of a cartridge that is positioned within a magnetic field, exciting atoms in the medical fluid in the first portion of the cartridge by applying radio frequency energy to the medical fluid in the first portion of the cartridge, receiving radio frequency energy generated by the excited atoms in the medical fluid in the first portion of the cartridge, and determining a concentration of a substance in the medical fluid based on the received radio frequency energy generated by the excited atoms in the medical fluid in the first portion of the cartridge.

A haemodialysis machine 1 comprises: an extracorporeal blood circuit 10, a dialyser 20, a dialysate circuit 30 and a control unit 40, wherein the extracorporeal blood circuit 10 and the dialysate circuit 30 are respectively in fluid communication with the dialyser 20; and a first extracorporeal blood sensor unit 50 comprising an analyte sensor 51, configured to provide signals responsive to sensing of analytes, and an auxiliary circuit 52, wherein the first extracorporeal blood sensor unit 50 is fluidically coupled to the extracorporeal blood circuit 10; wherein the first extracorporeal blood sensor unit 50 is arrangeable in: a first arrangement, wherein the analyte sensor 51 is in fluid communication with the extracorporeal blood circuit 10; and a second arrangement, wherein the analyte sensor 51 is in fluid communication with the auxiliary circuit 52; optionally, wherein the control unit 40 is configured to control the dialysate circuit 30 based, at least in part, on a first set of signals, including a first signal, received from the first extracorporeal blood sensor unit 50, provided by the analyte sensor 51 when the first extracorporeal blood sensor unit 50 is arranged in the first arrangement.

A method of acquiring liquid biological samples from an extracorporeal circuit for subjecting a patient to an extracorporeal blood purification treatment includes a sampling phase wherein: I) a first sampling port is in fluidic communication with a first collection chamber via a first hydraulic machine, the first sampling port being operatively connected to a first haematic line inputted to a haemodiafilter of the extracorporeal circuit; II) a second sampling port is in fluidic communication with a second collection chamber via a second hydraulic machine, the second sampling port being operatively connected to a second haematic line outputted from said haemodiafilter; III) a third sampling port is in fluidic communication with a third collection chamber via a third hydraulic machine, the third sampling port being operatively connected to an effluent line of the haemodiafilter, wherein each hydraulic machine fills a corresponding collection chamber with a corresponding biological sample.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

The present invention relates to an apparatus for sample taking from a fluid-conducting system, wherein the apparatus has at least one adapter which comprises at least one septum and at least one cannula displaceable relative to the septum, wherein the cannula is displaceable such that it penetrates the septum in a sample taking position and does not penetrate the septum in a flushing position; and wherein the adapter has at least one flushing region for a flushing medium which is arranged such that it is in fluid communication with the inner space of the cannula in the flushing position of the cannula; and wherein the apparatus has at least one receiving region having locking means for the fluid-conducting system by which the fluid-conducting system is fixable in a defined position relative to the adapter. The present invention furthermore relates to a blood treatment device and to a method for taking a sample from a fluid-conducting system.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in fluid communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood in a blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.