A fluid extraction implantable system shaped and sized to be implanted in a patient, including: a fluid extraction chamber having a flat and thin shape connected to a draining tube and including at least one external flat surface, wherein the at least one external flat surface is configured to be attached to a tissue surface when a negative pressure is applied on the draining tube, wherein the chamber extracts fluids from the tissue by applying the negative pressure through the flat surface on the attached tissue surface.

An extracorporeal blood treatment machine for carrying out a blood treatment including a machine front on which a hollow fiber filter module is arranged in a horizontal position, which hollow fiber filter module includes a cylindrical housing, a blood chamber having a blood inlet nozzle and a blood outlet nozzle and a solution chamber having a solution inlet nozzle extending transversely to the longitudinal direction of the hollow fiber filter module and a solution outlet nozzle extending transversely to the longitudinal direction of the hollow fiber filter module, the solution chamber being semi-permeably communicated at least in portions with the blood chamber, wherein a height potential is present in the horizontal position between the solution inlet nozzle and the solution outlet nozzle so that drainage of solution is enabled via one of the solution nozzles and evacuation of air bubbles is enabled via an other of the solution nozzles.

Systems and methods for removing carbon monoxide from whole blood are provided. In one configuration, an extracorporeal phototherapy system includes an oxygenator and a light source configured to output light and arranged to emit the light output by the light source onto at least one surface of the oxygenator. The oxygenator includes a plurality of membrane layers each having a plurality of microporous hollow fiber membranes. The plurality of microporous hollow fiber membranes each include an external surface and an internal channel. Each of the plurality of membrane layers may be rotationally offset with respect to an adjacent layer. The oxygenator further includes a gas inlet port in fluid communication with a first end of the internal channels, a gas outlet port in fluid communication a second end of the internal channels, a blood inlet port, and a blood outlet port.

The present invention provides a hemodiafiltrator comprising two compartmentalized dialysate chambers coaxially arranged in tandem. A single packed bundle of hollow fibers for blood flow is enclosed coaxially along a longitudinal axis inside the dual dialysate chambers. A configuration of a tandem arrangement of the dual dialysate chambers at least comprises a first dialysate chamber for an acidic dialysate with a varying level of urea and a second compartmentalized dialysate chamber for a basic dialysate with no urea but with a level of ammonia up to a level detected in normal human blood.

A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

Membrane oxygenators useful in a variety of medical situations, including various short-term procedures and relatively longer-term life support, and components of membrane-based oxygenators, such as conditioning modules for exchanging oxygen for carbon dioxide during extracorporeal conditioning of blood, are described. A conditioning module includes a plurality of mats of hollow fibers and a potting material disposed throughout the peripheral edges of the mats to create a circumferential seal that defines a passageway through the plurality of fiber mats having a substantially circular cross-sectional shape. The circumferential seal defines an effective fiber length for each of the hollow fibers. A resisting member is disposed across the proximal ends of at least some of the hollow fibers and is adapted to resist fluid flow into each of the hollow fibers based on the effective fiber length of the particular hollow fiber.

A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

Dialysis systems and methods for operating dialysis machines (e.g., peritoneal dialysis machines) for conducting dialysis treatments are disclosed. The dialysis system may include a dialysis machine for transferring dialysate to a patient from a dialysate bag. The dialysate may flow from the dialysate bag through a disposable cartridge or cassette positionable within the dialysis machine. A filter may be included in, coupled to, etc., the dialysis machine. In use, the filter may be configured to filter out air content from the dialysate. In some embodiments, the filter may be incorporated into and/or operatively coupled to the disposable cartridge or cassette inserted into the dialysis machine.

A hollow-fiber-type blood processing device and methods for its manufacture include a hollow fiber membrane bundle which is obtained by bundling a large number of hollow fiber membranes into a columnar shape. A sheet body is mounted on an outer peripheral portion of the hollow fiber membrane bundle. The sheet body is expandable as a result of being woven from a sheet material. An inner diameter of the sheet body in a natural state where no external force is applied to the sheet body is smaller than the outer diameter of the hollow fiber membrane bundle.

Various sorbent cartridges for use in sorbent dialysis are constructed to allow even dialysate stream flow through the sorbent cartridges, at relatively high flow rates, with sufficient engagement with sorbent media within the sorbent cartridges and without creating drill-through problems. The sorbent cartridges may have various columns and/or compartments for housing the sorbent media. The sorbent cartridges may have various horizontally oriented restrictors, with particularly sized holes, and with various vertically oriented side walls, that both form the various columns and/or compartments and that direct and control the dialysate stream through the sorbent cartridges in an even manner.