A medical infusion fluid handling system, such as an automated peritoneal dialysis system, may be arranged to de-cap and connect one or more lines (such as solution lines) with one or more spikes or other connection ports on a fluid handling cassette. This feature may reduce a likelihood of contamination since no human interaction is required to de-cap and connect the one or more lines and the one or more spikes. For example, the automated peritoneal dialysis system may include a carriage arranged to receive the one or more lines each having a connector end and a cap. The carriage may move along a first direction so as to move the connector ends of the one or more lines along the first direction, and a cap stripper may be arranged to engage with the caps on the solution lines on the carriage. The cap stripper may move in a second direction transverse to the first direction, as well as to move with the carriage along the first direction.

A porous hollow fiber membrane is provided for the treatment of a protein-containing liquid, which can effectively separate and remove a substance such as a small diameter virus, and which can allow effective permeation of a useful substance to be recovered such as protein in high concentration. The porous hollow fiber membrane has an asymmetric structure having a dense layer in an outer layer only and contains a hydrophobic polymer and a first hydrophilic polymer, the surface and the porous part of the hollow fiber membrane are coated with a second hydrophilic polymer, the hydrophobic polymer is a polysulfone-type polymer, the first hydrophilic polymer is a copolymer of vinylpyrrolidone with vinyl acetate, and the second hydrophilic polymer is a polysaccharide or a polysaccharide derivative. The porous hollow fiber membrane is obtained by co-dissolving the hydrophobic polymer and the first hydrophilic polymer and then the second hydrophilic polymer is coated.

Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.

A system includes a device having a blood side, a solution side, and a semipermeable membrane structurally configured for diffusion of one or more solutes therethrough. The system also includes a first extracorporeal circuit having one or more first fluid connectors for connecting the blood side of the device to the vascular system of a first animal, a second extracorporeal circuit including one or more second fluid connectors for connecting the solution side of the device to the vascular system of a second animal, a first pump in fluid communication with at least one of the first and second extracorporeal circuits, and a driver mechanically coupled to the first pump, the driver configured to drive the first pump using energy from an energy source.

Devices, systems, and methods can be used to deliver temperature-controlled medical fluids to patients. For example, this disclosure provides devices, systems, and methods for controlling the temperature of dialysate delivered to a patient during a peritoneal dialysis treatment.

Embodiments of the present disclosure provide a membrane oxygenator including an upper cover, a lower cover, a shell, and an oxygenation structure. Both ends of the shell are connected with the upper cover and the lower cover respectively. The oxygenation structure includes a mandrel, an oxygen pressure membrane, and a temperature-changing membrane, wherein an upper end of the mandrel enters a first blood path space of the upper cover, a lower end of the mandrel is opposite to a blood outlet of the lower cover, the oxygen pressure membrane is provided around the mandrel and connects a first gas path space and a second gas path space, and the temperature-changing membrane wraps around the oxygen pressure membrane. A gap is provided between the temperature-changing membrane and an inner wall of the shell. A blood inlet is provided on the shell near the upper cover.

A container for warming fluids comprises an inlet port, an outlet port, a fluid conduit configured for fluidly communicating the inlet and outlet ports, and deflection sections. The fluid conduit has a non-constant maximum width in a direction of fluid flow through the fluid conduit. The deflection sections further comprise an entry section and an exit section, each respective exit section being arranged downstream, in the direction of fluid flow, from each respective entry section. The maximum width of the fluid conduit decreases along the direction of fluid flow through the entry section over a first distance and the maximum width of the fluid conduit increases along the direction of fluid flow through the exit section over a second, different distance. A blood treatment apparatus including the above-described container is also provided.

A fluid handling cassette, such as that useable with an automated peritoneal dialysis (APD) cycler device or other infusion apparatus, may include a generally planar body having at least one pump chamber formed as a depression in a first side of the body and a plurality of flowpaths for a fluid that includes a channel. A patient line port may be arranged for connection to a patient line and be in fluid communication with the at least one pump chamber via at least a first one of said flowpaths, and an optional membrane may be attached to the first side of the body over the at least one pump chamber. In one embodiment, the membrane may have a pump chamber portion with an unstressed shape that generally conforms to the depression of the at least one pump chamber in the body and is arranged to be movable for movement of the fluid in a useable space of the at least one pump chamber. One or more spacers may be provided in the at least one pump chamber to prevent the membrane from contacting an inner wall of the at least one pump chamber. The patient line, a drain line, and/or a heater bag line may be positioned to be separately occludable in relation to one or more solution lines that are connectable to the cassette.

A system includes a dialyzer having a blood side and a dialysate side, a first extracorporeal circuit including one or more first fluid connectors structurally configured to connect the blood side of the dialyzer to the vascular system of a kidney patient, and a second extracorporeal circuit including one or more second fluid connectors structurally configured to connect the dialysate side of the dialyzer to the vascular system of a healthy animal. The present teachings may thus include a system where hemodialysis is performed using a healthy animal (e.g., a person with normal kidney function) to help remove harmful solutes from, and provide helpful solutes to, a kidney patient. In this manner, the healthy animal is virtually donating its kidney function to the kidney patient.

A fluid extraction implantable system shaped and sized to be implanted in a patient, including: a fluid extraction chamber having a flat and thin shape connected to a draining tube and including at least one external flat surface, wherein the at least one external flat surface is configured to be attached to a tissue surface when a negative pressure is applied on the draining tube, wherein the chamber extracts fluids from the tissue by applying the negative pressure through the flat surface on the attached tissue surface.