A medical infusion fluid handling system, such as an automated peritoneal dialysis system, may be arranged to de-cap and connect one or more lines (such as solution lines) with one or more spikes or other connection ports on a fluid handling cassette. This feature may reduce a likelihood of contamination since no human interaction is required to de-cap and connect the one or more lines and the one or more spikes. For example, the automated peritoneal dialysis system may include a carriage arranged to receive the one or more lines each having a connector end and a cap. The carriage may move along a first direction so as to move the connector ends of the one or more lines along the first direction, and a cap stripper may be arranged to engage with the caps on the one or more lines on the carriage. The cap stripper may move in a second direction transverse to the first direction, as well as to move with the carriage along the first direction.

A bioartificial liver (BAL) based on human induced pluripotent stem cells (iPSCs)-derived hepatocyte-like cells (HLCs) and a multilayer porous bioreactor is provided. The plasma separation/retransfusion loop part includes a blood input pipe, an exhaust pipe spring clamp, a blood input peristaltic pump, a heparin pump, a plasma separation column, a first pressure monitor, and a heater. The cell reactor/plasma component exchange double-loop part includes a plasma input peristaltic pump, and a semipermeable membrane exchange column, a plasma exchange peristaltic pump, a red blood cell (RBC) pool, a membrane lung, a multilayer porous bioreactor, a second pressure monitor, and a third pressure monitor arranged in a 37° C. dedicated incubator. An outlet of the third pressure monitor and a blood cell outlet are connected to an inlet of the first pressure monitor, and then connected to the heater and a blood output pipe in sequence.

The present disclosure discloses an integrated membrane oxygenator including an oxygenator and a filter attached to the oxygenator. The oxygenator may include an upper cover, a lower cover, a shell, and an oxygenation structure. Two ends of the filter may be respectively connected with the upper cover and the lower cover. The oxygenation structure may include a mandrel, an oxygen pressure membrane, and a temperature-changing membrane arranged inside the shell. The filter may include a filter shell, a diversion structure, and a filter screen arranged inside the filter shell. An inlet of the filter shell may be connected with a blood outlet on the lower cover of the oxygenator, and blood oxygenated by the oxygenator may directly enter the filter for filtration.

The embodiments of the present disclosure may provide a membrane oxygenator with a built-in filter, including an upper cover, a lower cover, a shell and an oxygenation structure, wherein two ends of the shell may be respectively connected to the upper cover and the lower cover, and the oxygenation structure may be disposed in the shell, including a mandrel, a filter screen, an oxygen pressure membrane, and a temperature-changing membrane in turn from a center to an outside. The blood may flow in from an upper blood inlet of the membrane oxygenator, traverse the temperature-changing membrane, oxygen pressure membrane and filter screen in turn, and then flow out from a blood outlet under the mandrel. During a process of traversing, a flow rate of the blood may gradually slow down, and the blood may fully contact the oxygen pressure membrane and the filter screen.

In a method for manufacturing an oxygenator, an intermediate spacer is disposed between a cylindrical heat exchange unit configured by winding a first hollow fiber membrane and a cylindrical gas exchange unit configured by winding a second hollow fiber membrane so that a first gap is formed between one end portions of the heat exchange unit and the gas exchange unit, and a first partition section of a first cover member is inserted into the first gap. In such an oxygenator, a first end portion of the intermediate spacer is located at a part that does not overlap the first partition section in a radial direction in the heat exchange unit and the gas exchange unit. The intermediate spacer is formed by winding an intermediate hollow fiber membrane.

A medical fluid system includes a medical fluid pump configured to pump a medical fluid; electronics associated with the medical fluid pump or with other components of the medical fluid system; a thermoelectric heater positioned and arranged to heat medical fluid pumped by the medical fluid pump, the thermoelectric heater including a heated side and a cooled side; a heat exchanger through which medical fluid pumped by the medical fluid pump is heated, the heat exchanger positioned and arranged so as to be in thermal communication with the heated side of the thermoelectric heater; and a mounting plate, the electronics supported by the mounting plate, the mounting plate positioned and arranged so as to be in thermal communication with the cooled side of the thermoelectric heater.

A container system configured to transfer heat to a fluid contained within the container system, such as dialysate. The container system may be configured to fluidly couple to a medical machine. The container system includes a flexible material comprising a wall of the container system. In examples, the flexible material defines a container volume configured to contain the fluid. The flexible material mechanically supports a circuit configured to generate and transfer heat to the fluid. The circuit is configured to flex and/or bend when the flexible material flexes and/or bends. In examples, the container system includes control circuitry configured to cause the circuit to generate heat based on a temperature of the fluid.

An oxygenator apparatus for use in an extracorporeal circuit. The apparatus includes a housing and a membrane assembly disposed within the housing. The membrane assembly includes a first plurality of gas exchange elements disposed in a first zone and a second plurality of gas exchange elements disposed in a second zone. The second zone is arranged concentrically around the first zone. The first and second plurality of gas exchange elements are fluidly open along a body and fluidly separated along a distal end. The first zone is configured to be fluidly coupled to an oxygen source and the second zone is configured to be fluidly coupled to a negative pressure source. A blood flow path includes a generally radial flow through the first zone to add oxygen to the blood and the second zone to separate gaseous micro emboli from the blood through the plurality of gas exchange elements.

Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented.

A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.