A warming unit (21) coupled or configured to be coupled to a heated portion (19) of a fluid circuit (6, 7, 10, 11, 13, 14, 15; 107) of a medical device (1, 100). The warming unit (21) comprises a leakage current reduction circuit (35) configured to perform the following procedure: connecting a heat transfer element (22) of the warming unit (21) to a ground connection (33) through a resistance element (34), which keeps a normal condition patient leakage current below a first limit value, and disconnecting the heat transfer element (22) from the ground connection (33) if a current indicating that the patient is connected to the mains voltage is sensed through the resistance element (34), in order to keep a fault condition patient leakage current below a second limit value.

An extracorporeal blood cooling or heating circuit includes an intravenous catheter for withdrawing a patient's blood coupled to a combined pump/heat exchanger device. One or more sensors are provided upstream and/or downstream of the pump/heat exchanger device for measuring pressure, temperature, fluid flow, blood oxygenation, and other parameters, A controller is operative!}′ coupled to the pump/heat exchanger device and the one or more sensors to control the speed of the pump inside the pump/heat exchanger device and regulate the blood temperature by controlling the operation of the heat exchanger. The combined pump/heat exchanger device includes a housing having at least one inlet and at least one outlet, a pump portion defining a blood circuit inside the housing, and a heat exchanger portion contained within the housing for selectively heating or cooling the blood.

A blood oxygenator is disclosed comprising a housing, a blood inlet, a blood outlet, a spiral volute, a gas inlet, an oxygenator fiber bundle, and a gas outlet. The housing encloses the fiber bundle and provides the structure for the blood flow path and connectors. The fiber bundle comprises gas-exchange membranes which transfer oxygen to the blood and remove carbon dioxide when the blood flows across the membranes. The spiral volute guides the blood to flow through the fiber bundle. A gas flow chamber receives sweep gas containing oxygen and distributes the sweep gas into the fiber membranes, which gas is then exchanged with the blood being oxygenated.

An extracorporeal blood heating and cooling system that is connectable to an oxygenator of a cardiopulmonary bypass system, the heating and cooling system comprising: a heater-cooler unit; a coolant flow circuit that is configured to pass coolant through the heater-cooler unit and the oxygenator; and a cardioplegia coolant circuit that is configured to pass coolant through the heater-cooler unit and a cardioplegia heat exchanger; wherein when the heating and cooling system is in a purging mode, the coolant flow circuit and the cardioplegia coolant circuit contain temperature-controlled coolant having a trisodium phosphate concentration of about 1-35 millimole/liter; wherein when the heating and cooling system is in a coolant mode, the coolant flow circuit and the cardioplegia coolant circuit contain temperature-controlled coolant having a trisodium phosphate concentration of about 1-10 millimole/liter; and wherein when the heating and cooling system is in the coolant mode or the purging mode, a first and second plurality of coolant conduits within the oxygenator and the cardioplegia heat exchanger are capable of maintaining a trisodium phosphate concentration ratio across the wall of such coolant conduits of at least 100:1, from the interior to the exterior of each coolant conduit. Methods of purging and operating such extracorporeal blood heating and cooling systems are also disclosed.

Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented.

Disclosed is an artificial heart and lung apparatus (100) that can be connected to a patient (P), and transfers removed blood to a human body via a roller pump (120), the system including: the roller pump (120); a blood removal line (101) which transfers removed blood to the roller pump (120); a first blood transfer line (104) that transfers blood, which is transferred from the roller pump (120), to the human body; a blood removal rate sensor (111) that is provided in the blood removal line (101); and a control unit (140), in which the control unit (140) performs control such that a blood transfer rate of the roller pump (120) is in a specific range with respect to a blood removal rate measured by a blood removal rate sensor (111).

A blood purification device includes a device body and a cassette. The cassette includes: a casing that accommodates a removal water receptacle; and pump tube. The device body includes fingers, a driving unit, and a housing. The cassette can be attached to and removed from the housing of the device body so that the pump tubes are positioned between the plurality of fingers and the outer surfaces of the casing.

A method includes, after an extracorporeal blood treatment, connecting a fluid source to an access line that is connected to a patient, and delivering a fluid from the fluid source to the access line to infuse blood from the access line to the patient, wherein the fluid delivered to the access line has a temperature from about 30 degrees Celsius to about 38 degrees Celsius.

An extracorporeal blood cooling or heating circuit includes an intravenous catheter for withdrawing a patient's blood coupled to a combined pump/heat exchanger device. One or more sensors are provided upstream and/or downstream of the pump/heat exchanger device for measuring pressure, temperature, fluid flow, blood oxygenation, and other parameters. A controller is operatively coupled to the pump/heat exchanger device and the one or more sensors to control the speed of the pump inside the pump/heat exchanger device and regulate the blood temperature by controlling the operation of the heat exchanger. The combined pump/heat exchanger device includes a housing having at least one inlet and at least one outlet, a pump portion defining a blood circuit inside the housing, and a heat exchanger portion contained within the housing for selectively heating or cooling the blood.

A portable adapter is provided that can include a closure system configured to control the flow of blood and/or dialysate between the adapter and a blood treatment apparatus. Modular systems are also provided that include the portable adapter engaged with various units such as a portable blood processing module, a non-portable base module, and/or a remote module. Methods of conducting blood treatments such as blood circulation, hemodialysis, and hemofiltration, hemodiafiltration, using the modular systems are also provided. The systems, units, and methods enable the engagement and disengagement of the adapter from the various units to conduct, interrupt, and resume blood treatments without disconnecting the adapter from the vasculature of a patient. Modular systems including interchangeable portable and base modules configured for various blood treatments are also provided that can be engaged and disengaged with each other without disconnecting the portable module from the vasculature of a patient.