An implantable or wearable kidney enclosure that is cylindrical, ovoid, or otherwise non-angular e.g., not rectangular or cuboid), having a circular or oval hemofilter that provides a blood flow pattern from an internal, central artery source radially outwards. Due to the efficient flow of the circular filter design, the enclosure can be made in a cylindrical low profile shape, resulting in a compact enclosure highly suitable for implantable and wearable dialysis applications.

Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.

Dialyzer systems can consolidate multiple technologies and functionalities of blood treatment systems in a significantly integrated fashion. For example, this disclosure describes dialyzer systems that include a magnetically driven and magnetically levitating pump rotor integrated into the dialyzer. Such a dialyzer can be used with treatment modules that include a magnetic field-generating pump drive unit. In some embodiments, the dialyzers include pressure sensor chambers with flexible membranes with which corresponding pressure transducers of the treatment modules can interface to detect arterial and/or venous pressures.

Methods, systems, and devices are disclosed, embodiments of which provide single pass dialysis to remove water and uremic toxins is performed simultaneously with the albumin dialysis therapy by passing the albumin solution through a dialysis filter which dialyses it before the solution is returned to the cycler. In embodiments, the single pass dialysis stage is upstream of the albumin filtering stage.

The present invention relates to a device (1) and a corresponding method for determining residual blood in a dialyzer (2) comprising a holding device (6) configured to accommodate a dialyzer (2), an image capturing device (7) configured to capture at least one image of a dialyzer (2) accommodated by the holding device (6), in particular a filter (4) located in the dialyzer (2), and generate corresponding image data having a plurality of image points, each of which assigned at least one respective intensity value, in particular a color value, and a control device (9) configured to determine residual blood information characterizing the presence and/or content of residual blood in the dialyzer (2) on the basis of a statistical frequency of at least a portion of the intensity values in the at least one image. The invention further relates to a dialysis system having such a device (1).

A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.

A system for hemodialysis can include a first dialysis system and a second dialysis system configured to be used in alternate fashion to provide hemodialysis for a patient, wherein the first dialysis system is configured to be worn by the patient, and wherein the second dialysis system is configured to be positioned on a support independent of the patient. The first dialysis system can be configured to be coupled to a belt worn by the patient around a waist of the patient during its operation. The second dialysis system can configured to be coupled to a stationary support during its operation.

The present invention provides a method for hemodiafiltration which applies dialysate gradient across a multi-chambered hemodiafiltrator having a plurality of compartmentalized tubular dialysate chambers. An acidic dialysate with urea at a concentration is applied to a first dialysate chamber. A less acidic dialysate with a lower concentration of urea than those for the first dialysate chamber is applied to a second dialysate chamber. A basic dialysate with no urea but with ammonia at a concentration up to a concentration detected in normal human blood is applied to a last dialysate chamber. The concentrations of urea for the first and second dialysate chambers decrease over time to zero prior to conclusion of hemodiafiltration.

A system for hemodialysis can include a first dialysis system and a second dialysis system configured to be used in alternate fashion to provide hemodialysis for a patient, wherein the first dialysis system is configured to be worn by the patient, and wherein the second dialysis system is configured to be positioned on a support independent of the patient. The first dialysis system can be configured to be coupled to a belt worn by the patient around a waist of the patient during its operation. The second dialysis system can configured to be coupled to a stationary support during its operation.

A dialysis device implantable in a patient for dialysis includes a filtration unit. The filtration unit includes at least one dialysis chamber for containing and/or circulating dialysate; and at least one blood chamber for containing and/or circulating blood of the patient, disposed on at least one dialysis chamber and being in communication with the at least one dialysis chamber. Each of the at least one dialysis chamber and the at least one blood chamber comprise at least one inlet for circulating fluid into and/or out of the at least one dialysis chamber and the at least one blood chamber. The at least one dialysis chamber and the at least one blood chamber are configured such that the blood in the at least one blood chamber and the dialysate in the at least one dialysis chamber operably interact with each other for dialysis.