An extracorporeal blood treatment device is provided that includes a hydraulic system having a plurality of flow paths. A control unit provides an operating mode for disinfecting the hydraulic system with a liquid supplied via one of the flow paths. A method for operating the extracorporeal blood treatment device is also provided. The hydraulic system has a valve device that provides several switching positions. The valve device has an inlet for a liquid for disinfecting the hydraulic system, and a plurality of outlets. In a first switching position, the inlet is connected to one of the outlets. In another switching position, the inlet is connected to a plurality of the outlets. The inlet of the valve device is in fluid communication with a first flow path and the outlets are in fluid communication with another flow path. Disinfecting liquid can simultaneously be supplied to the individual flow paths.

This disclosure relates to dialysis systems and methods. In some implementations, a dialysis system includes a dialysis machine with a fluid line and a drain line, a blood line set configured to be connected to the dialysis machine, and a drain apparatus coupled to the dialysis machine. The drain apparatus includes a chamber configured to receive an end of a patient line of the blood line set, an inlet line, an outlet line, and a valve. The inlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the fluid line of the dialysis machine. The outlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the drain line of the dialysis machine. The valve is configured to control flow of fluid through the outlet line.

A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

A device and method are described for the treatment of blood, which device may be used in conjunction with or in place of a failed Kidney. The device includes an ultrafiltration unit to remove proteins, red and white blood cells and other high molecular weight components, a nanofiltration unit to remove glucose, at least one electrodeionization unit to transport ions from the blood stream, and a reverse osmosis unit to modulate the flow of water, to both the blood and urine streams. In one embodiment, a specialized electrodeionization unit is provided having multiple chambers defining multiple dilute fluid channels, each channel filled with an ion specific resin wafer, and electrodes at the extremity of the device and proximate each of the resin filled dilute channels. By selective application of voltages to these electrodes, the ion transport functionality of a given dilute channel can be turned on or off.

An apparatus and a method for extracorporeal blood treatment, especially for hemodialysis, wherein blood of a patient is flushed with a dialysate in a dialyzer and wherein a variable correlated with the plasma sodium concentration of the blood is measured. The composition of the dialysate then is adjusted in response to the variable measured so that the plasma sodium concentration of the blood at least at the end of the blood treatment has the same value as at the beginning. For measuring the variable correlated with the plasma sodium concentration of the blood, for example a bypass operation can be implemented in which the dialysate is guided past the dialyzer so that a residual volume on the side of the used dialysate at least partially adopts the concentration of the substances dissolved on the blood side.

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Dialysis machines comprising a feed arrangement (170) to supply a dialysis fluid to a dialyzer (150) during dialysis treatment and a return arrangement (171) to remove the dialysis fluid from the dialyzer during dialysis treatment and forward it to an exit (129); a feed recirculation circuit (172) to allow a fluid of the feed arrangement to be re-circulated in a fluid loop path comprising, at least a portion of, the feed arrangement and the feed recirculation circuit and a return recirculation circuit (173) to allow a fluid of the return arrangement to re-circulate in an auxiliary fluid loop path comprising, at least a portion of, the return arrangement and the return recirculation circuit. A controller (160) configured to perform disinfection by re-circulating a disinfectant and/or a heated fluid through said fluid loop path and/or through said auxiliary fluid loop path. The dialysis machine (1) further comprises a feed forward arrangement (172) connected to the fluid loop path and arranged to enable a fluid of the feed arrangement (170) to be forwarded to the exit (129) by-passing the auxiliary fluid loop path.

A blood based solute monitoring system for measuring at least one blood solute species that has a first recirculation flow path in communication with a dialyzer. The first recirculation flow path is configured to allow a fluid to recirculate through a dialyzer such that the concentration of at least one solute species in the fluid becomes equilibrated to the solute species concentration of the blood compartment of the dialyzer. The blood solute monitoring system has at least one sensor to measure a fluid characteristic.

A device for extracorporeal blood treatment, in particular a dialysis device, including an internal fluidic system for a treatment liquid, in particular for a dialysis liquid, the internal fluidic system having at least two liquid connectors for connecting a substantially cylindrical filter element, in particular a dialyzer, to the internal fluidic system for passing a treatment liquid through the filter element, and including a mounting for exchangeably holding the filter element in such a way that the filter element can be connected to the liquid connectors of the internal fluidic system and to an extracorporeal blood line in an intended manner, wherein the mounting for holding the filter element is designed in such a way that a cylinder longitudinal axis of the filter element is substantially horizontally aligned.