A portable hemodialysis system is provided including a dialyzer, a closed loop blood flow path which transports blood from a patient through the dialyzer and back to the patient, and a closed loop dialysate flow path which transports dialysate through the dialyzer. Preferably, the hemodialysis system includes a sorbent filter in the dialysate flow path. Furthermore, the hemodialysis machine includes a blood pump, and a pair of dialysate pumps. A processor controls the flow of blood through the blood flow path, and the processor controls the flow of dialysate through the dialysate flow path. In addition, the processor stores a patient treatment plan wherein the flow rate of the dialysate through the dialysate flow path reduces throughout the patient's treatment to maximize the amount of urea removed by the sorbent filter.

A portable hemodialysis system is provided comprising a dialyzer, having a dialysate-replenishing system for replenishing minerals of dialysate in the dialyzer, the dialysate-replenishing system includes: a sorbent filter configured to remove ammonia from the dialysate, the sorbent filter having an outlet that outputs the dialysate to a dialysate flow path; a first reagent source containing a first reagent solution; a first pump configured to inject the first reagent solution into the dialysate flow path; a first mixer coupled to the dialysate flow path and downstream of the first pump, the first mixer configured to mix the dialysate with the first reagent solution; a conductivity sensor configured to measure a level of dissolved solids in the dialysate after the first mixer; and a controller configured to adjust a flow rate of the first reagent solution by adjusting the first pump based at least on the level of measured levels.

Sorbent cartridges having a flow control insert to improve the functional capacity of a sorbent cartridge is provided. Flow control inserts can include a plurality of flow channels filled with sorbent material through which fluid to be regenerated can travel in the sorbent cartridge.

The present invention provides a novel device and method of generating and bagging dialysate for continuous veno-venous hemodialysis (CVVHD). The procedure involves the use of standard hemodialysis (HD) equipment and the device of the present invention. The device of the present invention is an adapter configured to be used with standard hemodialysis equipment.

A diagnosis method for a conductivity sensor for a dialysis fluid preparation apparatus and personal dialysis apparatus, that mix water, an A fluid and a B fluid in predetermined proportions respectively to prepare a dialysis fluid and measures the concentration of the prepared dialysis fluid by concentration measurement means is described. The diagnosis method and the respective apparatus is based in measuring the A fluid without the B fluid being present in the solution.

The present disclosure relates to hollow fiber membrane filtration devices for the production of ready-to-use dialysis fluid by forward osmosis, and a cost-efficient and simple method and system for preparing ready-to-use dialysis fluid from raw water and liquid dialysis concentrate by forward osmosis.

In one aspect, a valve actuation system includes a drive unit including an actuator configured to engage and move multiple valves disposed within a fluid cassette to selectively open and close each valve of the multiple valves and a positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the multiple valves.

A pump cassette is disclosed. The pump cassette includes a housing having at least one fluid inlet line and at least one fluid outlet line. The cassette also includes at least one reciprocating pressure displacement membrane pump within the housing. The pressure pump pumps a fluid from the fluid inlet line to the fluid outlet line. A hollow spike is also included on the housing as well as at least one metering pump. The metering pump is fluidly connected to the hollow spike on the housing and to a metering pump fluid line. The metering pump fluid line is fluidly connected to the fluid outlet line.

The present invention refers to a system and method for connecting a concentrate container with a blood treatment device with improved hygiene. Furthermore, the invention refers to a container and blood treatment device to be used in a method according to the present invention.

In one aspect, a valve actuation system includes a drive unit including an actuator configured to engage and move multiple valves disposed within a fluid cassette to selectively open and close each valve of the multiple valves and a positioning frame disposed adjacent the fluid cassette and along which the drive unit can be moved in three dimensions to align the actuator with a selected valve of the multiple valves.