The disclosure relates to a blood treatment device for use in blood treatment therapies, comprising: an extracorporeal blood circuit, a dialyzer and a dialysis fluid circuit, wherein the extracorporeal blood circuit and the dialysis fluid circuit are separated from each other via a membrane provided in the dialyzer, via which blood can be filtered; at least one substitution solution pump, which is configured to supply a substitution solution to the extracorporeal blood circuit before and/or after the dialyzer; an effluent pressure sensor, which is configured to measure a pressure in the dialysis fluid circuit after the dialyzer, and a control unit, which is configured to automatically reduce a flow rate of the at least one substitution solution pump when an effluent pressure measured by the effluent pressure sensor drops during an ongoing blood treatment therapy.

This invention is directed to system and methods for the oxygenation of the blood of a patient, comprising an extracorporeal blood circulation path adapted to be coupled to the patient's vascular system, and comprising apparatus for oxygenating blood flowing therein and withdrawing CO2 therefrom, wherein the flow rate of blood flowing in said extracorporeal blood circulation path does not exceed ⅖ of the patient's blood flow. The extracorporeal blood circulation path preferably comprise a cartridge including an oxygenator and at least one cannula.

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

The present invention relates to an apparatus for regenerating a dialysis solution, wherein the apparatus has a first circuit and a second circuit, with the first circuit having a container for receiving the consumed dialysis solution, the primary side of a filter connected downstream of the container, and a return line from the primary side of the filter into the container, with the filter being configured to prepare purified water from the consumed dialysis solution, and with the second circuit having the secondary side of the filter, the dialyzate side of a dialyzer, and a return line from the dialyzate side of the dialyzer into the container. The present invention further relates to a method of regenerating a dialysis solution.

Systems for monitoring fluid flow in an extracorporeal blood circuit are described. The blood circuit of such systems can include plod pump having a pumping chamber of the blood pump separated from a control chamber of the blood pump by a flexible diaphragm. The control chamber can be configured to transmit positive or negative pressure to operate the diaphragm. The system can include a pressure sensor configured to measure pressure in the control chamber of the blood pump, and a controller configured to receive information from the pressure sensor and to control the delivery of pressure to the control chamber of the blood pump. The controller can also be configured to cause the application of a time-varying pressure waveform on the blood pump diaphragm during a fill-stroke of the blood pump, and to monitor a pressure variation in the control chamber measured by the pressure sensor. When so configured, such controller can transmit a value representing a magnitude of the measured pressure variation to a display associated with the extracorporeal blood circuit.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

The present invention relates to a system (100) for extracorporeal blood treatment comprising a first inlet (1) for introducing a bloodstream to be treated into the system (100), three blood treatment apparatus (A, D, G), as well as an outlet (2) for discharging a treated bloodstream from the system (100), wherein the system comprises an adsorber apparatus (A) and/or a plasma separator apparatus, a dialysis apparatus (D) and a gas exchange apparatus (G), and wherein the three blood treatment apparatus (A, D, G) are sequentially connected in series in a functional state of system (100) application between the inlet (1) and the outlet (2) of the system relative to a direction of blood flow of a bloodstream to be treated and can be consecutively perfused extracorporeally by a bloodstream to be treated. The present invention further relates to a treatment apparatus comprising such a system, a kit comprising the components of such a system, a method for operating such a system (100) as well as a method for extracorporeal blood treatment with such a system (100).

A method of operating an extracorporeal blood treatment system to infuse blood into a patient at an end of an extracorporeal blood treatment includes clamping an access line of an arterial line set. The method further includes, after clamping the access line, initiating an operation to generate negative pressure in the arterial line set. The method further includes, after generating the negative pressure in the arterial line set, unclamping the access line to draw fluid in the access line further into the arterial line set in a direction away from an end of the access line that is connectable to an arterial access of the patient. The method further includes initiating an operation of a fluid pump engaged with the arterial line set such that the fluid in the arterial line set is infused into the patient through a venous line set.

A blood purification apparatus with a blood circuit that allows a patient's blood to extracorporeally circulate and a blood purifier connected to the blood circuit and that purifies the blood in extracorporeal circulation are attachable, the blood purification apparatus including a dialysate introduction line through which dialysate is introduced into the blood purifier; a dialysate drain line through which waste dialysate resulting from blood purification performed by the blood purifier is drained from the blood purifier; and a concentration-detecting unit that detects a concentration of a predetermined substance in the waste dialysate flowing through the dialysate drain line. The blood purification apparatus includes a control unit that establishes a state of equilibrium where the concentration of the predetermined substance in the waste dialysate flowing through the dialysate drain line and a concentration of the predetermined substance in the blood flowing through the blood circuit are equal or approximate to each other; a storage unit that stores a value detected by the concentration-detecting unit in the state of equilibrium as an equilibrium value; and a clear-space-calculating unit that calculates clear space in accordance with the value detected by the concentration-detecting unit and the equilibrium value stored in the storage unit, the clear space being an index representing a volume of purification of a patient achieved by blood purification treatment.

A pulmonary artery (PA) via trans-septal to left atrial (LA) percutaneous dual lumen cannulation system which reduce the pressure of the right ventricle provides drainage of pulmonary artery blood with bypassing the lung while return the blood to the Left Atrium (LA) without the need for thoracotomy for a wearable pump less extra corporeal lung assist (pECLA) to remove CO.sub.2, pump less extra corporeal membrane oxygenation (ECMO), para-corporeal pump driven CO.sub.2 removal, extra corporeal CO.sub.2 removal (ECCO.sub.2R) pump driven, para-corporeal pump driven membrane oxygenation, or extra corporeal membrane oxygenation (ECMO) with extra-corporeal pump. By establishing percutaneously a shunt with a dual lumen cannula between PA and LA using the PA-LA pressure gradient as the driving force for the blood flow through the drainage lumen, CO.sub.2 removal device, or oxygenator and return cannula lumen in the vascular system.