The present disclosure describes a device and method to clear solutes from a patient's blood while maintaining fluid balance. In some implementations, the device and method is used to assist the filtration functions of a patient's liver or kidney. The device includes a plurality of hollow fibers that pass through a sequence of alternating filtration chambers and infusion chambers. The filtration chambers filter the patient's blood while the infusion chambers rehydrate the filtered blood.

A dialysis apparatus has a replenisher passage selectively connectable to an arterial side passage (pre-replenishment) or a venous side passage (post-replenishment) in a blood circuit. A supply side pressure sensor measures a pressure of a dialysate supply passage and a collection side pressure sensor measures a pressure of a dialysate collection passage. The connection passages each have one end communicating with the arterial side passage or the venous side passage of the blood circuit and another end connected to the dialysate collection passage. It is determined whether the replenisher passage is connected to the arterial side passage or the venous side passage, based on a differential pressure of pressures measured by the supply side pressure sensor and the collection side pressure sensor, in a state where a dialysate pump (liquid delivery device) causes dialysate to flow into the blood circuit from the replenisher passage.

An extracorporeal blood treatment apparatus is provided comprising a filtration unit (2) connected to a blood circuit (17) and to a dialysate circuit (32); a control unit (12) is configured for calculating a sodium concentration value for the blood; the estimation of the sodium concentration includes the sub-step of calculating the sodium concentration value as an algebraic sum of a main contribution term based on the isoconductive sodium concentrate and of an offset contribution term based on a concentration of at least a substance in the dialysis fluid chosen in the group including bicarbonate, potassium, acetate, lactate, citrate, magnesium, calcium, sulphate and phosphate.

It is described an extracorporeal blood treatment apparatus (1) with a user interface (12) device capable configuring and allowing execution of one or more isolated ultrafiltration tasks during the course of a dialysis treatment. The extracorporeal blood treatment apparatus (1) is controlled in a normal mode, where dialysis fluid is fed to the blood treatment unit (2), and in an isolated ultrafiltration mode, where fresh dialysis fluid is no longer fed to the blood treatment unit (2).

A blood purification apparatus capable of achieving a simplified configuration and switching between hemodialysis treatment (HD), hemofiltration treatment (HF), and hemodiafiltration treatment (HDF) as well as selecting from pre-dilution, post-dilution and pre and post-dilution easily and smoothly. The blood purification apparatus includes: a valve means 3 that is capable of closing and opening a dialysate introduction line and a dialysate supply line L3 in any manner, and a control unit 5 that operates the valve means 3 to allow any treatment to be performed selected from hemodialysis treatment in which the dialysate supply line L3 is closed while the dialysate introduction line L1 is opened, hemofiltration treatment in which the dialysate supply line L3 is opened while the dialysate introduction line L1 is closed, and hemodiafiltration treatment in which hemodialysis and hemofiltration are performed concurrently by alternately closing and opening the dialysate introduction line L1 and the dialysate supply line L3.

The exemplary systems and methods may generate treatment records for extracorporeal blood treatments. The treatment records may include a plurality of values of various parameters. The various parameters may include a compulsory set of parameters that are preset, a dependent set of parameters that a dependent on one or more of a selected treatment and a system configuration, and a discretionary set of parameters that are selected by a user.

An apparatus (1) for CRRT is provided comprising a blood circuit (10, 20, 30, 60) with a blood removal line (20), a treatment unit (10), and a blood return line (30). A replacement fluid container (78) is configured for containing a medical fluid, a pre-infusion line (70) has a first end (70-1) connected to the replacement fluid container (78) and a second end (70-2) connected to the blood removal line (20) and a blood pump (22) is active on the blood circuit. A replacement fluid pump (72) is active on the pre-infusion line (70), a dialysate circuit (40, 50, 70) comprises an effluent line (50) configured for discharging fluid from the second chamber, and a control unit (80) is connected to the replacement fluid pump (72) and to the blood pump (22) and is configured for performing a rinse-back procedure for restituting blood to a patient. The rinse-back procedure comprises conveying blood contained in the blood circuit (10, 20, 30, 60) towards the second end (30-2) of the blood return line (30) using the medical fluid.

A CRRT apparatus comprising a filtration unit (2), a blood circuit (17), a blood pump (21), a dialysate line (13) and one or more lines (8; 51; 57; 58; 63; 69; 67; 74) to transfer a respective solution into blood; a fluid source for each of said one or more lines, wherein said solution comprises at least one buffer agent in the form of bicarbonate or bicarbonate precursor. A control unit (12) is configured to receive a patient prescription and to determine a parameter (J.sub.buffer_load/BW) indicative of a steady state acid-base balance in the blood of the patient who has to undergo a CRRT blood treatment, wherein said parameter is determined as a function of the concentration of said buffer agent in said fluid source and as a function of the estimated or calculated patient systemic steady state concentration of bicarbonate and/or bicarbonate precursors.

The exemplary systems and methods may generate treatment records for extracorporeal blood treatments. The treatment records may include a plurality of values of various parameters. The various parameters may include a compulsory set of parameters that are preset, a dependent set of parameters that a dependent on one or more of a selected treatment and a system configuration, and a discretionary set of parameters that are selected by a user.

The invention relates to a blood line (108) comprising an infusion site (145) intended to inject into the line a solution comprising: a first main channel (200) having a first passage section, a second main channel (220) having a second passage section, means for the formation (210) of a turbulence area located downstream from the first main channel, located upstream from the second main channel, these formation means comprising a first fluid passage means (224) defining a reduction (225) in the passage section and whose smallest passage section is smaller than the first passage section and smaller than the second fluid passage section, a secondary channel (230) comprising an inlet (231) for letting in the solution and an outlet (232) in fluid communication with the first main channel or the means for the formation of a turbulence area or the second main channel.