A blood processing apparatus (1) comprises a measurement device (8) having a first chamber element (80) for measuring a haematocrit value of a blood fluid, the first chamber element (80) comprising a first inlet port (800) connectable to a first reservoir container (2) for allowing a flow from the first reservoir container (2) into the first chamber element (80) and a first outlet port (801) for allowing a flow out of the first chamber element (80), and the second chamber element (81) comprising a second inlet port (810) for allowing a flow into the second chamber element (81) and a second outlet port (811) connectable to a second reservoir container (3) for allowing a flow out of the second chamber element (81) towards the second reservoir container (3). The blood processing apparatus furthermore comprises a first pump mechanism (600) for pumping a blood fluid in a flow direction (F1) from the first reservoir container (2) towards the blood processing apparatus (1), and a second pump mechanism (610) for pumping a blood fluid in a flow direction (F2) from the blood processing apparatus (1) towards the second reservoir container (2). Herein, the first pump mechanism (600) is located upstream of the first inlet port (800) of the first chamber element (80) and the second pump mechanism (610) is located upstream of the second inlet port (810) of the second chamber element (81). In this way a blood processing apparatus comprising a measurement device is provided which in an easy and reliable manner allows for a measurement of in particular a haematocrit value in the incoming blood flow as well as the outgoing blood flow.

A blood processing apparatus (1) comprises a measurement device (8) having at least one chamber element (80, 81) for receiving a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L), a bottom wall (803, 813) and a top wall (805, 815) together defining a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The blood processing apparatus (1) further comprises a holder device (9) for holding the measurement device (8), the holder device (9) comprising a base (90) having a reception opening (900) for receiving the measurement device (8) and a closure element (91) movably arranged on the base (90) for locking the measurement device (8) in an inserted position in the reception opening (900). An ultrasonic sensor element (92, 93) of the holder device (9) is arranged on the base (90) and adapted to produce an ultrasonic sensor signal (P) for measuring a haematocrit value of a blood fluid in the flow chamber (802, 812). Herein, the ultrasonic sensor element (92, 93), in the inserted position of the measurement device (8), faces the bottom wall (803, 813) of the at least one chamber element (80, 81) for transmitting the ultrasonic signal (P) into the flow chamber (802, 812) through the bottom wall (803, 813). In this way a blood processing apparatus comprising a holder device for a measurement device is provided which allows to easily insert the measurement device into the holder device and allows for a reliable measurement of, in particular, a haematocrit value of a blood flow through the measurement device.

A tubing set for use in a blood processing apparatus comprises a measurement device (8) having at least one chamber element (80, 81) for measuring a haematocrit value of a blood fluid, wherein the at least one chamber element (80, 81) extends along a longitudinal axis (L) and comprises a circumferential wall (804, 814) extending about the longitudinal axis (L) and encompassing a flow chamber (802, 812), the at last one chamber element (80, 81) further comprising an inlet port (800, 810) for allowing a flow of a blood fluid into the flow chamber (802, 812) and an outlet port (801, 811) for allowing a flow of a blood fluid out of the flow chamber (802, 812). The tubing set furthermore comprises an inlet-side tube section (21, 31) connected to the inlet port (800, 810) and an outlet-side tube section (22, 30) connected to the outlet port (801, 811). Herein, the inlet port (800, 810) and the outlet port (801, 811) are arranged on the circumferential wall (804, 814) and are displaced with respect to each other along the longitudinal axis (L). In this way a tubing set comprising a measurement device is provided which in an easy and reliable manner allows for the measuring of a haematocrit value of a blood fluid.

A method for detecting occult hemorrhages is provided. The method comprises: obtaining, by a medical system comprising a blood monitoring system, a first hematocrit concentration prior to infusing a saline solution into a bloodstream of the patient; infusing, by the medical system, the saline solution into the bloodstream of the patient; obtaining, by the medical system, a second hematocrit concentration after infusing the saline solution into the bloodstream; determining, by the medical system, a first absolute blood volume based on the first hematocrit concentration and the second hematocrit concentration; generating, by the medical system, a notification indicating a potential occult hemorrhage based on the first absolute blood volume and a pre-defined absolute blood volume threshold; and providing, by the medical system, the notification indicating the potential occult hemorrhage.

Methods and systems for maintaining patient fluid balance during an extracorporeal cell treatment are disclosed. The method includes minimizing the amount of saline or other fluid that is returned to the donor. Saline used during priming of the fluid circuit may be used to increase the volume of the collected cells to arrive at a treatment-ready product with a suitable hematocrit.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit, such as veno-venous extracorporeal membrane oxygenation, includes determining (i) a first arterial carbon dioxide content or surrogate and (ii) a first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; establishing a second removal rate of carbon dioxide from the blood in the oxygenator in the extracorporeal blood oxygenation circuit; determining (i) a second arterial carbon dioxide content or surrogate and (ii) a second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood; and calculating a cardiac output of the patient corresponding to a blood flow rate through the extracorporeal blood oxygenation circuit, the first arterial carbon dioxide content or surrogate, the first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; the second arterial carbon dioxide content or surrogate and the second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood.

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit, such as veno-venous extracorporeal membrane oxygenation, includes determining (i) a first arterial carbon dioxide content or surrogate and (ii) a first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; establishing a second removal rate of carbon dioxide from the blood in the oxygenator in the extracorporeal blood oxygenation circuit; determining (i) a second arterial carbon dioxide content or surrogate and (ii) a second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood; and calculating a cardiac output of the patient corresponding to a blood flow rate through the extracorporeal blood oxygenation circuit, the first arterial carbon dioxide content or surrogate, the first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the first removal rate of carbon dioxide from the blood; the second arterial carbon dioxide content or surrogate and the second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to the second removal rate of carbon dioxide from the blood.

A system for calculating cardiac output of a patient on an extracorporeal blood oxygenation circuit includes determining the cardiac output corresponding to a blood flow rate through an extracorporeal blood oxygenation circuit, a first arterial carbon dioxide content or surrogate, a first carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to a first removal rate of carbon dioxide from the blood; a second arterial carbon dioxide content or surrogate and a second carbon dioxide content or surrogate in the blood delivered to the patient after passing the oxygenator corresponding to a second removal rate of carbon dioxide from the blood.