A blood bag system (10) includes a blood bag (14) to which centrifugal force is provided in a state where whole blood or a blood component is stored, and a first tube (22) that circulates a fluid centrifugally separated from the blood bag (14). The first tube (22) includes an extending portion (112) extending in an approximately perpendicular direction to a centrifugal direction into which the centrifugal force is applied. Further, a branch tube (114) that can store blood existing in the extending portion (112) is provided at a side of the centrifugal direction of the extending portion (112).

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

A disposable blood separation set and a centrifugal blood processing system comprising a blood processing chamber adapted to be mounted on a rotor of a centrifuge; a frustro-conical cell separation chamber in fluid communication with the processing chamber, the cell separation chamber having an inlet, a primary outlet and a side tap outlet adjacent the inlet. A valve that is responsive to centrifugal force (a “gravity” valve) selects between the outlet and the side tap outlet. The gravity valve is mounted on the rotor. When the rotor spins at high speed, the gravity valve may open the primary outlet and close the side tap outlet. When the rotor spins at a lower speed, the gravity valve may open the side tap outlet and close the primary outlet.

A method of collecting mononuclear cells includes separating whole blood into plasma and cellular components, purifying the plasma through a plasma adsorption column to create purified plasma, combining the cellular components with the purified plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component. Alternatively, whole blood may be flowed through an adsorption column to create purified whole blood, with the purified whole blood then being separated into mononuclear cells and at least one component.

A blood processing apparatus (1) comprises a measurement device (8) having a first chamber element (80) for measuring a haematocrit value of a blood fluid, the first chamber element (80) comprising a first inlet port (800) connectable to a first reservoir container (2) for allowing a flow from the first reservoir container (2) into the first chamber element (80) and a first outlet port (801) for allowing a flow out of the first chamber element (80), and the second chamber element (81) comprising a second inlet port (810) for allowing a flow into the second chamber element (81) and a second outlet port (811) connectable to a second reservoir container (3) for allowing a flow out of the second chamber element (81) towards the second reservoir container (3). The blood processing apparatus furthermore comprises a first pump mechanism (600) for pumping a blood fluid in a flow direction (F1) from the first reservoir container (2) towards the blood processing apparatus (1), and a second pump mechanism (610) for pumping a blood fluid in a flow direction (F2) from the blood processing apparatus (1) towards the second reservoir container (2). Herein, the first pump mechanism (600) is located upstream of the first inlet port (800) of the first chamber element (80) and the second pump mechanism (610) is located upstream of the second inlet port (810) of the second chamber element (81). In this way a blood processing apparatus comprising a measurement device is provided which in an easy and reliable manner allows for a measurement of in particular a haematocrit value in the incoming blood flow as well as the outgoing blood flow.

Methods and systems for processing suspensions of biological cells and microcarriers are disclosed. The biological cells are separated from the microcarriers by introducing the suspension into a spinning membrane separator whereby the biological cells pass through the membrane and the microcarriers do not pass through the membrane.

Systems and methods for the washing and processing of biological fluid/biological cells are disclosed. The systems and methods utilize a disposable fluid circuit including a spinning membrane separation device to wash the biological cells.

This disclosure relates to medical fluid sensors and related systems and methods. In certain aspects, a nuclear magnetic resonance device includes a support frame, a first magnet connected to the support frame, a second magnet connected to the support frame in a manner such that the second magnet is disposed within the magnetic field of the first magnet and a magnetic attraction exists between the first magnet and the second magnet, and a spacer disposed between the first magnet and the second magnet. The spacer is configured to maintain a space between the first magnet and the second magnet.

Described are embodiments that include methods and devices for separating composite liquids into components. Embodiments involve the use of a flexible membrane for separating a composite liquid into components. The composite liquid may include, in embodiments, a cellular containing liquid, such as whole blood or components of whole blood. In one specific embodiment, the composite liquid is a buffy coat.

A fluid processing device includes a controller, a centrifuge configured to receive and rotate a continuous-flow centrifuge chamber, a pump system, an optical detection assembly, and a pressure sensor. The controller executes a priming procedure in which a priming fluid is conveyed into the centrifuge chamber while the chamber is being rotated by the centrifuge, which moves air out of the chamber via a low-g outlet conduit. Upon detecting priming fluid exiting the centrifuge chamber via the low-g outlet conduit, the chamber is rotated at a higher rate to attempt to move any remaining air out of the chamber via the low-g outlet conduit. The controller then determines, based on signals from the optical detection assembly and pressure sensor, whether there is any air remaining in the centrifuge chamber. If so, the rotational rate is alternately decreased and increased until all the air has been cleared from the centrifuge chamber.