Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

An apheresis system may include an assembly for separating a component from a multi-component fluid, a processor, and a memory storing data for processing by the processor. The data, when processed, may cause the processor to run a calibration test on one or more instruments of the assembly and, based the one or more instruments failing the calibration test, calibrate the one or more instruments or lock the apheresis system for non-use. The apheresis system may include a pump configured to generate a calibration pressure at a test port and a pressure sensor configured to sense a pressure at the test port. The calibration test may include comparing the calibration pressure at the test port to the sensed pressure by the pressure sensor at the test port.

A soft cassette includes a body including a flexible material and first and second component. The body defines first and second lumens and first and second chambers. The first lumen extends between first and second ends. The first chamber is in the first lumen such that fluid passing through the first lumen passes through the first chamber. The second lumen is fluidly connected to the first lumen at a first junction between the first end and the first chamber and a second junction between the second end and the first chamber such that fluid passing through the second lumen bypasses the first chamber. The second chamber is in the second lumen. The first component is on a first side of the second chamber and includes a first ferromagnetic metal or magnet. The second component is on a second side of the second chamber and includes a second ferromagnetic metal magnet.

A method includes detecting a beginning of a donation process; in response to detecting the beginning of the donation process, providing an output; determining an amount of time remaining for the donation process; in response to detecting the amount of time remaining for the donation process, updating the output; detecting a loss in pressure; in response to detecting the loss in pressure, updating the output; detecting an ending of the donation process; and in response to detecting the ending of the donation process, updating the output. The donation process may include a plasma donation using an apheresis machine. The detecting the beginning of the donation process may include detecting a flow of fluid. The output may include one or more of a light and a sound. The output may be provided on a side of an apheresis machine.

A method includes detecting a condition including one or more of a change in flow of a fluid and a change in a composition of the fluid, issuing an alarm in response to the condition detected, lowering a flow rate; and attempting to restart process and increase the flow rate. The change in flow may include a change in pressure. The change in flow may be associated with a collapsed vein. The change in flow of the fluid may include detecting that the flow rate has fallen below a threshold. The change in the composition may be associated with a color. The change in the composition may include using a color sensor to detect one or more of a red, a green, and a blue reflection or transmission to detect red blood cells.

A modular serviceability sled includes a frame, subassembly, interconnection, gasket, and shielding component. The interconnection is operatively connected to the subassembly and includes an electrical, pneumatic, and/or hydraulic connection. The gasket can engage the frame and a base assembly of an apparatus. The shielding component can contact the frame and the base assembly and includes an electromagnetic interference and/or radio frequency shielding component. The sled is movable between an engaged state and a disengaged state. In the engaged state, the sled is at least partially within a receiving space of the apparatus, the gasket engages the frame and the base assembly, the shielding component contacts the frame and the base assembly, and the interconnection is operatively connected to a machine interconnection of the apparatus. In the disengaged state, the interconnection is disconnected from the machine interconnection and the sled is configured to freely move with respect to the base assembly.

A blood component sampling cassette which can be more efficiently manufactured at lower cost as compared to a typical cassette, a blood sampling circuit set, and a blood component sampling system. A blood component sampling cassette (22) includes a cassette main body (23) made of a soft material to which heat sterilization is applicable. The cassette main body (23) is provided with a retransfusion line (44). The retransfusion line (44) is provided with a reservoir (47) configured to temporarily store a blood component to be returned to a blood donor. The reservoir (47) is pressed by a retransfusion pump (49) to discharge the blood component from the reservoir (47).

Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.

A dialysis system may include a blood circuit, a cassette, a subsystem having a processor, a sensor, and a blood pumping mechanism, a housing in which the subsystem is arranged, a movable support arranged in the housing and configured to hold the sensor and/or the blood pumping mechanism of the subsystem, a cassette holder configured to removably receive the cassette, and a loading system. The loading system may be configured to move the movable support, e.g. by an axial movement, to a first position and to a second position relatively to the housing while the cassette holder is fixedly arranged in the housing. The loading system may have an electric motor controlled by the processor, a drive assembly coupled to the electric motor, and a guiding assembly configured to cooperate with the drive assembly.

A fluid sensor system that is configured to perform in-line monitoring is disclosed. The fluid sensor system can include a sensor module that includes a sensing channel configured to receive a sample fluid, two or more calibration compartments, and a sensing element configured to interact with the sample fluid in the sensing channel. The fluid sensor system can include a reader that is electrically and mechanically coupled to the sensor module. The reader includes a controller that is configured to control operation of the fluid sensor system.