A medical fluid management assembly includes a pneumatic manifold, a pump and valve engine, and a fluid manifold. The pneumatic manifold includes a plurality of pneumatic passageways and a plurality of pneumatic connectors. The pump and valve engine includes a plurality of valve chambers, at least one pump chamber, and a plurality of pneumatic connectors mated sealingly and releasably with the pneumatic connectors of the pneumatic manifold. The pump and valve engine also includes a plurality of fluid connectors. The fluid manifold includes a plurality of fluid pathways and a plurality of fluid connectors mated sealingly and releasably with the fluid connectors of the pump and valve engine.

A dialysis machine that includes a valve member having a deformable area configured to deform outwardly away when pressurized fluid is introduced into the valve member. The valve member is configured so that, when a dialysis fluid cassette is disposed in a cassette compartment of the dialysis machine and pressurized fluid is introduced into the valve member, the deformable area obstructs a fluid channel of the dialysis fluid cassette to control dialysis fluid flow therethrough.

A renal therapy machine includes a blood filter including a plurality of porous fibers; a blood circuit in communication with the blood filter; and a dialysate circuit in communication with the blood filter and operable with at least one pump, wherein the renal therapy machine is configured to perform a priming sequence in which a physiologically compatible solution, other than dialysate, primes the blood circuit and is flowed within the fibers and through pores in the fibers of the blood filter, and the pump of the dialysate circuit vents air from the blood filter into the dialysate circuit.

Dialysis systems comprising actuators that cooperate to perform dialysis functions and sensors that cooperate to monitor dialysis functions are disclosed. According to one aspect, such a hemodialysis system comprises a user interface model layer, a therapy layer, below the user interface model layer, and a machine layer below the therapy layer. The user interface model layer is configured to manage the state of a graphical user interface and receive inputs from a graphical user interface. The therapy layer is configured to run state machines that generate therapy commands based at least in part on the inputs from the graphical user interface. The machine layer is configured to provide commands for the actuators based on the therapy commands.

Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection. According to yet another approach, a double-needle fluid processing assembly may be converted into a single-needle configuration to allow for continued processing following mid-procedure termination.

This disclosure relates to dialysis systems and methods. In some implementations, a dialysis system includes a dialysis machine with a fluid line and a drain line, a blood line set configured to be connected to the dialysis machine, and a drain apparatus coupled to the dialysis machine. The drain apparatus includes a chamber configured to receive an end of a patient line of the blood line set, an inlet line, an outlet line, and a valve. The inlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the fluid line of the dialysis machine. The outlet line has a first end configured to be coupled to the chamber and a second end configured to be coupled to the drain line of the dialysis machine. The valve is configured to control flow of fluid through the outlet line.

An extracorporeal circuit has been conceived including: lines (16) which include passages for blood or a medical liquid; a connector (38, 40) at a free end of each of the lines (16); a cassette (18) supporting the lines, and dummy connectors (42, 44) attached to the cassette (18) and each adapted to form a mating connection with a respective one of the connectors (38, 40) at the free ends of the lines (16), wherein the connectors (38, 40) are arranged in accordance with a sequence in which the lines (16) are attached for a blood treatment session or are grouped in accordance with types of liquids to flow through the lines (16) during the blood treatment session. The extracorporeal circuit may be a circuit for dialysis and the circuit includes a hemodialyzer. Further, the connectors (38, 40) and dummy connectors (42, 44) may each be one of a male or female luer lock connector, and the dummy connectors (42, 44) may include both male and female connectors.

The invention relates to a device and a method for connecting a vial [1] to a container or to a fluid line and transferring the contents of a vial [1] to a container or to a fluid line, wherein the device has a first holder [4] which is suitable for accommodating a connecting device [8], a second holder [5] which is suitable for accommodating a vial [1], an actuating means [7] and a connecting device [8] which consists of an annular housing [13], an inside part [12] having at least one puncture device [14] and a tube connection [16], wherein the annular housing [13] of the connecting device [8] can be constructed to be rotatable about the inside part [12] in the function of a valve, so that by rotation of the housing [13] the flow paths of the connecting device [8] can be opened and closed.

Methods and systems for reducing bacterial contamination of platelets are disclosed. The methods and systems disclosed herein provide for the processing of a pre-determined volume of whole blood so as to reduce the risk that platelets separated and collected from the whole blood have a reduced risk of bacterial contamination.

A medicament preparation system, according to an embodiment, includes a water purification module and a medicament proportioning module. The system is configured to allow convenient and safe use in a home environment or a critical care environment as well as others affording safety, reliability, and a compact form factor.