Biological fluid processing cassettes with integrated filter structures are disclosed. A cassette body is formed of a generally rigid material, defining a plurality of internal fluid flow paths. The cassette body may be secured to a cassette cap to define a cavity, with a filter sealed within the cavity. Each of the cassette body and the cassette cap defines a port opening into the cavity, which allows fluid to flow from one of the internal fluid flow paths, into the cavity and through the filter, and then out of the cavity via the port of the cassette cap. Alternatively, the cassette body may define an external slot which receives at least a portion of a filter. Such a filter includes two ports, with one of the ports in fluid communication with a cassette port of the cassette body to allow fluid flow between the cassette body and the filter.

A modular cassette is provided for separating a composite fluid into at least two component parts thereof during centrifugation. The modular cassette includes: a housing defining a fluid inlet, a fluid outlet, and a chamber for fluid separation; a fluidic channel configured to provide fluid communication between at least two components of the modular cassette; a heat expanding valve including: a flow pathway including undulations configured to facilitate closing of the fluidic channel, wherein the heat expanding valve occludes one or more of the undulations of the flow pathway to close the fluidic channel; and a heating element configured to actuate the heat expanding valve.

An operational unit for locating and neutralizing pathogen cells in blood includes a time use cassette which has a plurality of thin holding chambers that are filled with blood drawn from a patient. A light source illuminates each of the holding chambers and passes light to an underlying sensor array such that the cells in the blood selectively block the light to produce shadow images of the cells in the sensor array. A processor performs pattern recognition to identify and locate the pathogen cells by use of an image library. After the pathogen cells are located, an electric field is activated in the cassette chamber areas that include the identified pathogen cells. Sufficient electric field energy is applied to destroy the identified pathogen cells. A pump refills the cassette holding chambers, returns the neutralized-pathogen blood to the patient, and the process is repeated for a period of time.

Dialysis systems are disclosed comprising new fluid flow circuits. Systems may include blood and dialysate flow paths, where the dialysate flow path includes balancing, mixing, and/or directing circuits. Dialysate preparation may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit fluid flow paths may be isolated from electrical components. A gas supply in fluid communication with the dialysate flow path and/or the dialyzer able to urge dialysate through the dialyzer and urge blood back to the patient may be included for certain emergency situations. Fluid handling devices, such as pumps, valves, and mixers that can be actuated using a control fluid may be included. Control fluid may be delivered by an external pump or other device, which may be detachable and/or generally rigid, optionally with a diaphragm dividing the device into first and second compartments.

An extracorporeal blood processing system comprises a plastic molded compact manifold that supports a plurality of molded blood and dialysate fluidic pathways along with a plurality of relevant sensors, valves and pumps. A disposable dialyzer is connected to the molded manifold to complete the blood circuit of the system. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine.

A fluid cassette, for example, a blood treatment cassette having a cassette body embodied as a hard part and, optionally, a film which is connected to the hard part and at least partially covers the hard part, wherein the hard part comprises at least one first alignment device, and a second alignment device which are optionally arranged at first and second opposite sides of the fluid cassette or are attached thereon. The disclosure relates in addition to a blood treatment apparatus.

A blood component collection system, which is one form of a biological component collection system, is equipped with a centrifugal separation device and a biological component collection device. The biological component collection device comprises a pressed soft portion pressed by a load detecting unit. The centrifugal separation device includes a collection and returning pump, and a control unit having an internal pressure computation unit which calculates a circuit internal pressure of the biological component collection device on the basis of a detection value of the load detecting unit. The internal pressure computation unit performs a zero reset process of setting a pressure value corresponding to the detection value of the load detecting unit, so as to become zero at each instance of a predetermined timing at which the collection and returning pump is stopped.

A fluid flow circuit assembly for a fluid processing device, comprising a housing having a plurality of openings, a separator disposed at least partially within the housing, and a plurality of flow paths communicating between an interior and an exterior of the housing via the plurality of openings, wherein the separator is disposed substantially at the center of the plurality of flow paths.

Provided is a photodynamic therapy device that enables efficient light irradiation of blood of a patient. A photodynamic therapy device (100) of this disclosure includes a cartridge (10) including a winding core and a tube arranged so as to be wound around the winding core, a casing (50) configured to accommodate the cartridge (10), and a light source (60), which is arranged inside the casing (50), and is configured to irradiate the tube with light. The tube arranged around the winding core has a cross section taken along a direction orthogonal to an extending direction of the tube, which has a first dimension in a first direction and a second dimension in a second direction orthogonal to the first direction. The second dimension is smaller than the first dimension. The second direction is directed outward with respect to the winding core.

Provided is a centrifuge cassette assembly (800) for separating a fluid and related method of manufacture. The cassette assembly includes a first chamber, a second chamber (308), a fluidic channel (808) creating a fluid connection between the first chamber and the second chamber, at least one molded insertion valve (600, 700) configured to control the flow of fluid in the fluidic channel and a heating element (802) for actuating the at least one molded valve. Further provided are Normally Open Valves (NOVs) (700) and Normally Closed Valves (NCVs) (600) which are capable of insertion into, and which control the fluid flow of, the centrifuge cassette assembly.