Systems and methods are provided for separating a red blood cell-containing fluid into separated red blood cells and another fluid constituent. A suitable system includes a disposable fluid flow circuit and a durable, reusable separation system, with the circuit being mounted onto or otherwise associated with the separation system. The circuit includes a membrane separator for separating the fluid into its constituent parts, as well as a leukoreduction filter. The leukoreduction filter may be used before or after the red blood cell-containing fluid has been passed into the membrane separator. The red blood cell-containing fluid (if the leukoreduction filter is positioned upstream of the membrane separator) or the separated red blood cells (if the leukoreduction filter is positioned downstream of the membrane separator) may also be passed through a microaggregate filter prior to passing through the leukoreduction filter.

A filter and a device including the filter may include a filter and a plurality of pores arranged two-dimensionally on the filter. The plurality of pores may include a plurality of first pores having a longer structure in a certain direction and a plurality of second pores having a longer structure in a direction different from that of the first pore. The first and second pores may have a two-dimensional arrangement in order to suppress or prevent the occurrence of cracks in the filter due to stress.

A method for filling and venting a device for extracorporeal blood treatment is disclosed, such as a patient module in a heart-lung machine, without attached patient. A filling liquid from a filling liquid container located higher than the device flows by gravity via a venous side of the system into a reservoir and flows onwards into a blood pump located at the lower end of the reservoir, wherein a first controllable valve (HC1) for a venting line of a filter is opened and, after the response of an upper filling level sensor in the reservoir, is closed. An upper level of the filter is positioned higher than the upper filling level sensor, and a start-stop motion of the blood pump is performed, as a result of which a stepped flooding of the filter is made providing for an advantageous de-airing of the device.

Treatment apparatus with liquid level controls for gas separation devices used to separate gas bubbles from liquids are described herein along with methods of controlling the level of liquids in the gas separation devices. The gas separation devices may be used in liquid treatment apparatus to separate gas bubbles from one or more liquids such as, e.g., physiological liquids (e.g., blood, etc.).

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 5 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees Celsius and to allow the blood to cool one or more degrees following heating. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees.

The invention relates to methods and systems for removal of pathogens from blood or blood products. The invention further relates to methods and systems for treatment and diagnosis of infection in the blood and/or sepsis in a patient in need thereof.

A heater-cooler apparatus of an extracorporeal perfusion system comprises at least one fluid circuit (102, 104) providing a supply of a heat transfer fluid to the perfusion system, a cold storage unit (266), and a refrigeration unit (250) for charging the cold storage unit (266). The cold storage unit (266) comprises a chamber (312) containing a liquid that freezes at a temperature above that to which the heat transfer fluid is cooled by the refrigeration unit (250), and a passage through which the heat transfer fluid is conveyed, the passage extending through the chamber (312). This allows a more effective cold storage unit to be provided.

The present disclosure relates to systems and methods for the separation of blood into blood products and, more particularly, to systems and methods that permit automated recovery of white blood cells after producing a leukocyte-reduced blood product.

A blood treatment device includes an extracorporeal blood circuit, a dialyzer and a dialysis fluid circuit. The extracorporeal blood circuit and the dialysis fluid circuit are separated from each other by a membrane provided in the dialyzer, by which blood can be filtered. At least one substitution solution pump supplies a substitution solution to the extracorporeal blood circuit before and/or after the dialyzer. A control unit calculates a difference or a backlog between an ideal target volume and an actually controlled volume of the supplied substitution solution, and temporarily increases a controlled flow rate of the substitution solution pump under corresponding controlling thereof by a predetermined, fixed percentage which is less than or equal to 5%, until the difference or the backlog between the actually controlled volume and the ideal target volume no longer exists, i.e. the actually controlled volume corresponds to the ideal target volume.

A method of circulating a flow of blood within a circulatory system of a body includes applying an extrathoracic pressure to the body with a fluid. An intrathoracic pressure is applied to the body with the fluid. The application of the extrathoracic pressure relative to the application of the intrathoracic pressure is varied, so as to circulate a flow of blood within the circulatory system of the body.