A medical fluid management assembly includes: a pneumatic manifold including a plurality of pneumatic passageways and a plurality of pneumatic connectors; a pump and valve engine including a plurality of valve chambers and at least one pump chamber, the pump and valve engine including a plurality of pneumatic connectors mated sealingly and releaseably with the pneumatic connectors of the pneumatic manifold, the pump and valve engine further including a plurality of fluid connectors; and a fluid manifold including a plurality of fluid pathways and a plurality of fluid connectors mated sealingly and releaseably with the fluid connectors of the pump and valve engine.

Techniques and systems for determining an arteriovenous (AV) fistula maturation in a patient may include detecting a first series of oxygen saturation levels of the patient at a central venous catheter (CVC) associated with a first series of hemodialysis treatments prior to the AV fistula implantation are described. The AV fistula may then be implanted in the patient. A second series of oxygen saturation levels of the patient at the CVC associated with a second series of hemodialysis treatments may be detected. The second series of oxygen saturation levels may be compared to a stable threshold mature AV fistula oxygen saturation level. Among other determinations from the comparison, in response to one or more of the second series of oxygen saturation levels meeting or exceeding the stable threshold mature AV fistula oxygen saturation level, determining the AV fistula is mature. Other embodiments are described.

Apparatus that detect an interruption of the connection between a blood treatment apparatus and a patient blood circulation which can be connected to the blood treatment apparatus via a connection means is described. The connection means can be attached to a fluid line. The apparatus includes a line shut-off and a pressure sensor which is configured to measure the fluid pressure prevailing in the fluid line at a position located between the line shut-off and the connection means. A control and evaluation unit is configured to evaluate the pressure or pressure curve occurring after blocking the line so as to detect an interruption or disturbance of the connection between the connection means and the patient blood circulation.

The invention relates to a device for extracorporeal blood treatment, comprising a blood treatment unit 1 that comprises at least one compartment 4. The invention further relates to a method for determining a hemodynamic parameter during an extracorporeal blood treatment by means of an extracorporeal blood treatment device. In order to determine the hemodynamic parameter, the conveying direction of the blood pump 10 is reversed from a normal blood flow to a reversed blood flow. In practice, it has been found that reversing the conveying direction of the blood pump for a measurement for determining a hemodynamic parameter carries the risk of blood clots reaching the patient, despite the dialyser holding back blood clots. The blood treatment device comprises an input unit 23 for inputting a time interval which can be specified by the user, taking into account the patient-specific and system-specific factors. The control and evaluation unit 12 of the blood treatment device is configured such that the operation of the blood pump 10 in the operating mode involving a reversed blood flow is only enabled during the time interval input by means of the input unit, the start of the time interval being determined from the point at which the blood treatment starts.

Embodiments of the disclosure provide a method for determining beginning blood volume of a patient during dialysis (e.g., hemodialysis). Ultrafiltration rates are determined at different time stamps during dialysis by obtaining a blood flowrate measurement and hematocrit measurements at input port and output port of a dialyzer connected to the patient. The flowrate and hematocrit measurements are used to determine fluid removed from the patient during dialysis. The ultrafiltration rates and fluid removed from the patient are used to determine the beginning blood volume of the patient.

The specification discloses a portable dialysis machine having a detachable controller unit and base unit with an improved reservoir heating system. The controller unit includes a door having an interior face, a housing with a panel, where the housing and panel define a recessed region configured to receive the interior face of the door, and a manifold receiver fixedly attached to the panel. The base unit has a reservoir with an internal pan and external pan, separated by a space that holds a heating element. The heating element is electrically coupled to electrical contacts attached to the external surface of the external pan.

The present teachings relate to a blood purification apparatus in which the connection of a substitution line to a collecting port can be checked accurately and instantly and even during blood purification treatment. A blood purification apparatus includes a blood circuit, a dialyzer, a dialysate introduction line, a dialysate drain line, a substitution line one end of which is connected to a collecting port provided at a predetermined position of the dialysate introduction line and an other end of which is connected to the blood circuit, a substitution pump configured to form a pressure-increasing portion that includes the collecting port, and a pressure-measuring device capable of measuring a pressure in the pressure-increasing portion. The blood purification apparatus performs a testing process by increasing a liquid pressure in the pressure-increasing portion by utilizing a liquid-feeding pressure applied from a liquid-feeding device and measuring the pressure with the pressure-measuring device.

A blood purification apparatus is provided that is capable of detecting an abnormal state of puncture into a blood vessel with an arterial puncture needle or a venous puncture needle. The blood purification apparatus includes an oscillating device capable of supplying an alternating current at a predetermined frequency and changing the frequency of the alternating current among a plurality of frequencies, a measuring device capable of measuring an impedance for each of the frequencies, a calculating device capable of acquiring an impedance frequency characteristic, a storage device capable of storing an impedance frequency characteristic acquired in a case of normal puncture into the patient's blood vessel with an arterial puncture needle and a venous puncture needle, and an identifying device capable of identifying whether the puncture into the blood vessel with the arterial puncture needle a or the venous puncture needle b is normal in accordance with the change observed between the impedance frequency characteristic acquired by the calculating device and the impedance frequency characteristic stored in the storage device.

A needle dislodgement and blood leakage detection device includes a sensor assembly having a flexible sensor and a flexible substrate. The flexible sensor is provided, on an underside thereof at a location close to the flexible substrate, with a photoelectric sensor including near infrared transmitters that are of an array arrangement. The photoelectric sensor includes a signal amplifier module and a signal filter module that are electrically connected. An alarm device is coupled to the sensor assembly and includes a microprocessor unit, which includes a digital signal converter module, a signal sampling module, a signal demodulation module, a signal processing module, a time division module, a storage module, and a wireless transmission module that are connected in series. The digital signal converter module is connected to the signal filter module. The storage module and the wireless transmission module are respectively connected to a display unit and a computer.

Devices, systems and methods for establishing a blood flow conduit between a chamber in a heart of a patient and a remote location. A blood inflow cannula having an outer surface and proximal and distal end portions. The distal end portion is configured for insertion into the chamber of the heart. First and second anchor elements have respective maximum width dimensions extending outwardly from the outer surface of the cannula. The first anchor element is positioned more distally than the second anchor element defining a tissue receiving space therebetween. The maximum width dimension of the first anchor element may be larger than the maximum width dimension of the second anchor element in use. The first anchor element is configured to be positioned inside the heart chamber and the second anchor element is configured to be positioned outside the heart chamber with heart tissue held in the tissue receiving space therebetween.