Catheter and catheter assemblies for extracorporeal circulation of body fluids, such as blood, are described. A catheter includes a septum that divides an internal lumen into fluidicly isolated drainage and infusion lumens. The infusion lumen extends along only a portion of the axial length of the catheter and terminates at an infusion opening defined by the circumferential wall of the elongate member of the catheter. The drainage lumen extends the full axial length of the catheter and is laterally accessible via first and second sets of drainage openings.

Cannulas for apical cannulation and methods of making and using the same are provided. The cannula includes a first elongated body defining a primary lumen, a second elongated body defining a first secondary lumen, a third elongated body defining a second secondary lumen, and a fourth elongated body defining a third secondary lumen. The primary lumen is configured to allow blood to flow therethrough. The first secondary lumen is configured to inflate an inflatable body, which is configured to engage an aortal wall proximate the aortic valve of the patient's heart to define a treatment space. The second secondary lumen is configured to selectively remove blood from the treatment space or introduce a cardioplegic solution into the treatment space. The third secondary lumen is configured to administer active decompression of the left ventricle of the patient's heart via suction.

Systems and methods are provided for performing a medical procedure within a patient's body that involves a thoracic duct including an ostium communicating with the patient's venous system. A distal end of a catheter is introduced through the patient's venous system into a body lumen adjacent the ostium of the thoracic duct. An expandable member on the distal end of the tubular member may be expanded adjacent the ostium, e.g., within the body lumen or the thoracic duct itself, and used to isolate the thoracic duct from the body lumen, whereupon a medical procedure may be performed via the thoracic duct. For example, lymphatic fluid may be removed from the thoracic duct through a lumen of the tubular member and/or one or more agents may be introduced into the thoracic duct through the tubular member.

A medical tube or cannula comprising enhanced imaging structure and/or materials is provided. In some embodiments, an otherwise solid echogenic band may be interrupted by echolucent features and/or materials. In other embodiments, an echogenic band may be adjacent to an echolucent band, while in other embodiments one or more echolucent bands may be provided. In some cases, two or more spaced-apart echolucent bands may be provided. In some embodiments, an echolucent band may comprise an echogenic feature or materials. Generally, the juxtaposition of echogenic and echolucent materials enhances the imaging contrast of an intravascular device and allows easy identification and positioning of the juxtaposed echogenic and echolucent regions.

A catheter for percutaneous cardiopulmonary support has a lumen through which blood flows to a living body. The catheter comprises a catheter tube including a tubular reinforcing body including a plurality of wires braided into a mesh shape and a resin layer provided so as to cover the reinforcing body. A plurality of side holes are formed at a distal end of the catheter tube to communicate the lumen with the outside of the catheter tube. The side holes allow the blood flowing through the lumen to flow out in a direction intersecting an axial direction of the catheter tube when the catheter tube is indwelled. The plurality of side holes preferably may be spirally arranged in a circumferential direction of the tube.

A system for preventing thrombosis in an implantable medical device includes an implantable medical device sized for implantation at least partially within a patient's body. The device includes an at least partially electrically conductive portion that is disposed within a patient's body upon implantation, an electrode coupled to the electrically conductive portion of the device; and a power source coupled to the electrode. The power source provides a negative electric charge to the at least partially electrically conductive portion for an indefinite period of time. The device may be configured to resist thrombosis, infection, and/or undesired tissue growth via the charged conductive portion once implanted. Exemplary embodiments of the implantable medical device include a hemodialysis vasculature graft, a dialysis catheter, a coronary artery, and a heart valve.

The present invention provides a bi-directional perfusion cannula for use in peripheral veno-arterial extracorporeal membrane oxygenation of a patient, the cannula comprising a cannula main body having a primary lumen, the primary lumen leading to a distal end of the cannula main body for providing retrograde blood perfusion, characterized in that the main body further comprises a passage for passing a second cannula therethrough, the passage being oriented such that when a second cannula is inserted into the passage the second cannula is arranged for providing anterograde blood perfusion.

A system for collecting and separating biological material includes a centrifuge tube, a separation tube having an open bottom, a cap, a plug for temporarily sealing the open bottom of the separation tube, and a separation medium disposable within the centrifuge tube. The centrifuge tube and the separation tube sealingly and releasably couple to the cap, such that, when coupled, the separation tube is positioned within the centrifuge tube. The cap is configured to facilitate and/or regulate the introduction of air, gas, or other matter into the separation tube. When fully sealed, the separation tube may be placed under a vacuum condition, whereby a needle apparatus is used to facilitate introduction of matter into the separation tube. When the separation tube is positioned within the centrifuge tube, the bottom portion of the separation tube is submersed in the separation medium.

A multi-lumen implantable device configured to deliver a therapeutic agent to a selected portion of a blood vessel is disclosed. As one example, an implantable device includes a first lumen configured to flow blood from an upstream end to a downstream end of the device when implanted in a blood vessel; a second lumen fluidly separated from the first lumen and configured for introducing a therapeutic agent to a selected, first portion of a wall of the blood vessel, between the upstream end and the downstream end of the device; and at least one sealing member configured to block the therapeutic agent from entering a second portion of the wall of the blood vessel, between the upstream end and the downstream end of the device.

A device for extracting arterial and pulmonary embolisms is described herein. The device comprises a suction catheter and a return catheter attached to a reservoir. The reservoir comprises two filters that filter out any unwanted material from the blood. The device may be controlled by a console with a pedal. Blood containing unwanted material is suctioned out of a patient, is filtered in the reservoir, and is returned to the patient. The device prevents blood loss from the patient by returning the blood back to the patient after it is filtered. Furthermore, the filtration system is designed to also remove air from the blood as it is suctioned from the patient.