A method of dispensing fluid includes three processes. A first one of these processes includes pumping fluid into a resilient variable-volume dispensing chamber. The dispensing chamber is in series with a normally present finite fluid impedance and an output. The impedance is sufficient so as to cause expansion of the dispensing chamber as it receives pumped fluid even while some fluid flows through the output. Another one of these processes includes repeatedly measuring a parameter related to volume of the dispensing chamber over time. A third one of these processes includes controlling the pumping of fluid based on repeated measurements of the parameter to produce a desired fluid flow through the output. A corresponding system for dispensing fluid implements these processes.

A system for modulating delivery of a fluid medium includes an injector for injecting the fluid medium during an injection cycle, a delivery catheter including a conduit for delivering the fluid medium, a manifold disposed in a fluid medium flow path between the injector and the delivery catheter, and a pulsatile generator. The pulsatile generator is configured to apply a pulsatile force to the fluid medium defined by a plurality of duty cycles during the injection cycle, each of the duty cycles including a first pressure level and a second pressure level that is lower than the first pressure level.

Embodiments of the current disclosure are directed toward systems, devices and methods for diabetes management. In particular, the present disclosure relates to systems, devices and methods for dispensing insulin to a patient using a miniaturized and portable patch pump.

A novel embodiment of a drive mechanism for use in a pump, for example, of the type that would be used in a wearable drug delivery system, comprises, a cylindrically-shaped slider element configured with a channel on a circumferential surface thereof defining one or more zig-zag-shaped tracks therethrough. One or more pegs are engaged within the tracks, such that a back and forth longitudinal motion of the slider element along a radial axis of the cylinder causes movement of the pegs along one of the tracks through the channel, thus providing a movement of the pegs around the circumference of the cylinder which imparts a rotational motion to a header element disposed co-axially with the slider. The header element is in turn connected to a gear train, for example, a planetary gear box, which is coupled to the pump via a linkage or other type of mechanism.

A pump subsystem for fluid delivery (e.g., in a wearable patch pump) is provided wherein pumping action is generated by linear piston movement that pulls a plug, which is interconnected to the piston between two mechanical extremes or end stops in a telescopic or variable volume fluid chamber. Such interconnection enables piston and plug to move a certain distance with respect to each other that corresponds to a predefined swept volume of the pump subsystem. Telescoping-like effect of relative piston and plug movement provides for intake and discharge of fluid with respect to the fluid chamber. Movement of plug within piston can be enabled by the friction of seals placed on the plug, which serve to provide resistance to piston motion and therefore force translation motion of the plug to lag relative to the piston translation motion during portions of the pump cycle.

Pump subsystem for fluid delivery (e.g., in a wearable patch pump) comprises a fluid chamber with pumping motion and a valve shaft assembly with valving motion, both being driven by the same drive mechanism. Fluid chamber has variable volume chamber provided by a piston driven by the drive mechanism and translated relative to a plug in the pump housing. Piston extends the fluid chamber during an intake stroke and retracts the fluid chamber during a discharge stroke. Valve assembly has at least one valve shaft controllably translated by the drive mechanism to selectively align a first throughway with an opening in the pump chamber and a fluid intake port for an intake stroke to draw fluid into the fluid chamber, and align a second throughway with the opening in the pump hamber and a fluid discharge port for an discharge stroke to discharge fluid from the fluid chamber.

An improved device delivers a fluid medicament to the subcutaneous tissue of a user. The device is better suited for patients with Parkinson's Disease and other central nervous system disorders, than conventional infusion devices. The device can include a reusable part including a drive component (e.g., motor) and control electronics and a disposable part including a medicament reservoir. Medicament can be evacuated from the medicament reservoir by a plunger assembly that includes a plunger attached to a lead screw that is rotated by a nut, all within the disposable part. The device can be fluidically coupled with the tissue via a flexible cannula. Various embodiments relate to an improved cannula insertion mechanism that delivers the cannula under a force applied by a spring. Various embodiments relate to improved filling of the device, for example, using a vial adapter and an automated filling station.

A pump for administering an agent to a patient includes a housing, a motor, a gearbox, a sensor, and a controller. The motor may be coupled to housing. The gearbox is operatively connected to the motor. The sensor senses a rotation of the motor. The controller acts to control operation of the motor and monitor the quantity of the agent delivered to the patient. The pump also includes a pump assembly such that the pump is configured such that the pump assembly may be interchangeable from a syringe pump assembly and a peristaltic pump assembly.

An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

A medication filling device and system are provided. The filling device is configured to attach to a medication delivery device and includes a vial attachment component configured to attach to a medication vial. The vial attachment component includes a pump, operable in forward and reverse directions, and an empty vial detection unit configured to detect whether a vial attached to the vial attachment component is empty. The filling device further includes a processor configured to receive a signal from the empty vial detection unit indicating whether a vial attached to the vial attachment component is empty, and a user interface configured to output an indication to a user indicating whether the vial is empty.