An apparatus includes an enclosure containing a hermetically sealed region, the enclosure configured to be implanted on or within a recipient. The apparatus further includes circuitry within the hermetically sealed region and configured to generate signals. The apparatus further includes at least one heating element configured to receive the signals and to generate heat in response to the signals. The apparatus further includes at least one flow control element outside the hermetically sealed region and configured to respond to the heat by controlling a flow of liquid through at least one cannula to controllably administer the liquid internally to the recipient.

A pump system is disclosed that comprises a control unit and one or more modular infusion devices removably docked to the primary control unit. Each modular infusion device comprises a pumping mechanism and a processor configured to control the pumping mechanism and communicate with the control unit. The modular infusion device is configured to manipulate a portion of a fluid delivery set to pump a fluid. The first processor and the second processor are configured to exchange one or more operating parameters when the modular infusion device is docked to the primary control unit. The modular infusion device is configured to pump the fluid after being undocked.

Features relating to a pumping mechanism of a peristaltic infusion pump are provided. Stabilizing protrusions are provided for one or more pumping fingers of the pumping mechanism, where the one or more pumping fingers move in a coordinated and synchronized fashion with respect to one another to provide a controlled peristaltic action against a flexible tube for delivery of a fluid to a patient. The protrusions extend outward from one or more side regions of the pumping fingers to create points of contact on a side-wall of a recess in a chassis in which the pumping mechanism is positioned. The points of contact serve to stabilize the fingers to prevent vibration and/or movement of the fingers against the sidewall.

An anesthesiology pump for automatic delivery and control of anesthetics to a patient provides a remote unit that may be carried by an anesthesiologist to improve supervision of the anesthesiology process without unnecessarily constraining the anesthesiologist's movement. The anesthesiology pump may assess one or both of a status of the anesthesiology procedure and the availability of the anesthesiologist to provide tailored alerts to the anesthesiologist when additional attention or availability may be needed. Availability may consider separation distance between the pump and the radiologist as well as express indications of availability. A set of predefined safe states permit a pump response when the anesthesiologist is not available and additional attention is required.

A contrast injector system includes one or more devices for reducing or eliminating risk of cross-patient contamination. In particular, the contrast injector system includes at least one of a sterilization device, vibration device, and illuminator device positioned on a component of the contrast injector system, where the sterilization device, vibration device, and/or illuminator device is in communication with a console of the contrast injector system. The sterilization device has an energy emitter positioned to emit energy to one or more components of the system. The vibration device is positioned on a component of the system so as to induce acoustic vibrations on a surface of such component. The illuminator device includes a light source positioned to illuminate a component of the system.

A cassette usable with an infusion pump includes a monolithic cassette body and a segment of resiliently deformable tubing for conveying a flow of liquid. The monolithic cassette body has an integrally formed free-flow protection device including a fixed pinch element and a deflectable pinch arm having a movable pinch element. The pinch arm normally resides in a closed position wherein the pinch elements cooperate to deform the tubing segment to stop flow. The pinch arm is resiliently deflectable away from the closed position to an open position permitting flow. Deflection of the pinch arm away from the closed position spring biases the pinch arm for automatic return to the closed position. The pinch arm may be moved to the open position by operating a door of the pump when the cassette is loaded in the pump, and manually for priming when the cassette is not loaded in the pump.

The present disclosure provides a method for delivering a neuroprotective polypeptide to at least a portion of a central nervous system (CNS) of a subject. The method includes administering to the systemic blood circulation of the subject a therapeutically effective amount of a neuroprotective polypeptide by a controlled-release formulation or a device providing a sustained release of the neuroprotective polypeptide including at least one neuroprotective polypeptide selected from the group consisting of GLP-1, exendin-4, or a therapeutically effective GLP-1 or exendin-4 analogue; the neuroprotective polypeptide binds to and activates a receptor that binds at least one of GLP-1, exendin-4, or a combination thereof; and the controlled-release neuroprotective formulation or the sustained release of the neuroprotective polypeptide enhances the delivery of the neuroprotective polypeptide across a blood-brain barrier (BBB) of the subject to at least a portion of the CNS relative to a rapid release formulation of the neuroprotective polypeptide. Also disclosed is a method of treating a subject with a CNS-related disease or reducing at least one symptom of a CNS-related disease in a subject in need thereof.

A system for monitoring upstream flow characteristics for a pump is provided. The system may receive one or more outputs from a fluid level sensor coupled with a pump. The system may detect based on at least the one or more outputs, an abnormal upstream flow condition in the pump, such as a full upstream occlusion in the tube, a partial upstream occlusion in the tube, an empty reservoir, and/or a backflow of the fluid into the drip chamber. The system may adjust, based on the detection of an abnormal upstream flow condition in the pump, operation of the pump.

A peristaltic pump includes a conduit having a first end tor receiving a fluid from a reservoir and a second end for delivering the fluid. A plurality of fingers are disposed at respective locations along a segment of the conduit and are configured to alternately compress and release the conduit at the locations. A cyclical pump mechanism is coupled to move the fingers between respective compressed and released positions in a spatio-temporal pattern so as to drive a predetermined quantity of the fluid through the segment of the conduit in each pump cycle. A motor is coupled to drive the pump mechanism. A controller is coupled to activate and deactivate the motor in alternation during each pump cycle with a duty cycle that varies within the pump cycle.

A control circuit of a piezoelectric driving device includes: a signal generation unit that inputs a state inspection signal to a plurality of piezoelectric elements connected to each other in parallel; and a state detection unit that detects a state of the plurality of piezoelectric elements based on a state detection signal generated from the plurality of piezoelectric elements in accordance with the state inspection signal.