Apparatus and methods for providing controlled pressure-flow pulses which purge a catheter system with turbulent flow flushing. Accomplishment of such controlled pressure-flow pulses is provided by a variety of inventive devices including a special plunger rod for a conventional syringe, other interactive parts for conventional syringes, an in-line catheter attachable device which automatically generates the controlled pressure-flow pulses and also single pulse, digitally operated devices.

Various methods and apparatus disclosed herein relate to apparatus and techniques for harvesting energy from operation of a syringe, and utilizing that energy for various purposes. In various embodiments, a method (400) for harvesting and using electrical energy during operation of a syringe (100, 300) may include: operating (402) the syringe, wherein operating includes displacing a plunger (112) of the syringe to draw fluid into a reservoir (114) of the syringe or expel fluid from the reservoir of the syringe; converting (404), by an electrical generator (120, 122) that is integral with the syringe, motion associated with displacing the plunger into electrical energy; and using (406) at least some of the electrical energy to at least temporarily store, in a memory component (136) integral with the syringe, one or more data points associated with operation of the syringe.

Examples of fluid delivery drive system and/or pump system that creates a vacuum in a fluid line for drawing and expelling fluid are provided. The vacuum may be created by separating two components that are positioned within the sealed fluid line. Once the two components are separated and the fluid is contained within the volume created between the separated components, the two components may be shuttled within the sealed volume. The movement of the two components can seal off an inlet to the fluid line and then open a pathway to an outlet from the fluid line while ensuring the created volume between the two components is maintained constant. The two components can then be moved back together to expel the fluid from the created volume through the outlet for delivery, for example, to a patient. Other examples are disclosed and described.

Embodiments of the present invention are directed to devices, systems and methods for delivering therapeutic fluid (e.g., insulin) into the body, including a skin adherable cradle, for retaining a therapeutic fluid dispenser for delivering a therapeutic fluid to a user.

An adapter for attaching a needle to a pump actuated vial for injection of a vaccine or drug using a syringe-type injection motion while eliminating the time-consuming preparation of the injection device. The adapter includes a spray pump device having a first end defining a luer tip and a second end configured for accessing a media reservoir to receive a metered dose of flowable media. The luer tip is configured to be secured to a needle cannula to deliver the metered dose of the flowable media received from the spray pump device.

In some embodiments, a housing can define a reservoir. A lower cap can be coupled to the housing and define an outlet, and an upper cap can be coupled to the housing and can define an inlet. The upper cap can include an extending portion extending laterally a distance beyond an outermost extending portion of the lower cap relative to a central axis of the housing such that, when the lower cap and the extending portion of the upper cap contact a horizontal surface, the central axis of the housing is transverse to the surface and a sealing member is configured to sealingly engage a sealing surface of a valve seat prior to a liquid fluid level within a reservoir decreasing below a minimum threshold fluid level.

A micro dosing device is presented for delivering a metered dose of a therapeutic fluid having a dosing unit with a dosing chamber, a connector unit at a distal end for fluidly connecting a medicament container to the dosing chamber, a connector unit at a proximal end for fluidly connecting the dosing chamber to a medicament delivery member, and an activation mechanism, wherein the dosing chamber is configured to receive and therapeutic fluid. Further, the micro dosing device can have a dosing mechanism which provides an exactly metered dose of fluid to be expelled by the medicament delivery member, when the activation mechanism is triggered by a user.

The invention provides a user-guidance device for informing a required change to a pump volume displacement parameter of a manual drug infusion pump assembly, for use with manually-controlled infusion of a drug into a patient. The user-guidance device comprises a measurement component arranged to measure the pump volume displacement parameter. The device further comprises a computing device arranged to calculate a measured rate of infusion of the drug based on the measured pump volume displacement parameter; and to calculate with reference to said measured rate of infusion and to at least one model selected from the group consisting of pharmacokinetic and pharmacodynamic models, a model-simulated drug concentration in the patient. The computing device may be arranged to derive user-guidance information based on the model-simulated drug concentration. The invention also provides a drug infusion system which includes the disclosed user-guidance device in combination with a manual drug infusion pump assembly.

A drug solution injection controller 10 includes a sub-reservoir 24 connected via a sub-line 26 to a main line 14 for performing continuous administration of a drug solution such that rapid administration of the drug solution from the sub-reservoir 24 by self-operation is enabled, and comprises: a priming flow path 46 configured to perform priming on at least one of the main line 14 and the sub-line 26; a closing mechanism 48 configured to close the priming flow path 46; and a connector holding part 84 holding a terminal connector 18 connected to the main line 14. Holding of the terminal connector 18 by the connector holding part 84 is allowed to be released due to operation of an operation switch 50 configured to activate the closing mechanism 48.

A high pressure delivery system for delivering a medicament, comprising a first chamber for storing a supply of the medicament, a gear pump assembly in fluid communication with the first chamber, said gear pump assembly having a dose inlet and a dose discharge, said dose inlet having a larger diameter than said dose discharge to provide a high pressure discharge, and a fluid connection path in fluid communication with the gear pump assembly for delivering the medicament to a high pressure area.