The invention discloses a miniature closed-loop artificial pancreas system, comprising: infusion unit configured to deliver drugs; program unit comprising input end and output end, and the input end comprises a plurality of electrically connective regions for receiving signals of analyte data in the body fluid, after the output end is electrically connected to the infusion unit, according to the received signals of analyte data in the body fluid, the program unit controls whether the infusion unit delivers drugs; an infusion cannula with conductive area, the infusion cannula is the drug infusion channel; and a plurality of electrodes for detecting analyte data in body fluid, the electrode comprising conductive-area electrode and cannula-wall electrode, and one or more cannula-wall electrodes being located on/in the wall of the infusion cannula. It takes only one insertion to perform both analyte detection and drug infusion.

A device (100) for delivering a medicament into a patient's body by injection into or through the patient's skin, including: a main body having a bottom enclosure (104) that has a top surface including a button guide latch (268); a reservoir (160) disposed within the main body for containing the medicament; an injection needle (152) for penetrating the skin of the patient, the needle (152) having a lumen and communicating with the reservoir (160) when the device (100) is activated; a pressurizing system (140, 144) for pressurizing the reservoir (160) when the device (100) is activated; and an activator button (128) movably disposed on the main body and movable from a pre-activated position to an activated position. The activator button (128) includes an activation arm (228). When the activator button (128) moves from the pre-activated position to the activated position, an end of the activation arm (228) engages with the button guide latch (268) and prevents return movement of the activator button (128).

Some embodiments of an infusion pump device may include a drive system that accurately and incrementally dispenses fluid from the pump device in a controlled manner. Particular embodiments of the drive system may include a rotational motor that is coupled to a string member, which is used to adjust a pawl relative to a ratchet body. In such circumstances, the drive system can provide a reliable and compact infusion pump device that accurately dispenses the desired volume of fluid.

A fluid infusion device, for delivery of a medication fluid to the body of a user, includes a housing, a fluid reservoir for the medication fluid, a dosing mechanism, an infusion component, and a mechanical actuator. The fluid reservoir and the dosing mechanism are located in the housing, and the dosing mechanism is coupled to receive the medication fluid from the fluid reservoir. The dosing mechanism has an adjustable fluid chamber that defines a variable dosage volume. The infusion component is coupled to the dosing mechanism to receive the medication fluid from the adjustable fluid chamber. The mechanical actuator is coupled to the dosing mechanism such that operation of the mechanical actuator causes the medication fluid to be expelled from the adjustable fluid chamber to the infusion component.

Disclosed is a syringe for a micro-dosing syringe pump. The syringe includes a reservoir having an outlet port; a plunger having a track, with the plunger received inside a portion of the reservoir; a plunger driver comprising a gear connected to one end of a shaft and a pin located adjacent an opposite end of the shaft, with the plunger driver received inside the plunger and with the pin located inside and engaging the track. In use, rotation of the gear in a first direction advances the plunger into the reservoir a first distance as the pin travels in the track and rotation of the gear in a second direction opposite the first direction advances the plunger a further distance into the reservoir as the pin travels in the track. The design prevents excess dosing in a runaway motor failure.

A repeater system may control a pump by using a repeater and a user interface. An adhesive patch system may be used for affixing a pump or other object to a human body. Such an adhesive patch system may include two sets of adhesive members, each member including an adhesive material on at least one side so as to attach to the body. The members of the first set are spaced to allow the members of the second set to attach to the body in spaces provided between the members of the first set, and the members of the second set are spaced to allow members of the first set to detach from the body without detaching the members of the second set. Also, fill stations and base stations are provided for personal pump systems.

The present disclosure relates to drug delivery devices, and in particular, to drug delivery devices configured to reconstitute a lyophilized drug powder into liquid form prior to delivery into a patients body. In some embodiments, such devices include a flexible drug reservoir having a proximal reservoir component storing a liquid diluent and a distal reservoir component storing a lyophilized drug powder, wherein the two compartments are separated by a frangible seal. A compression member may be positioned above the reservoir and held up by a releasable mechanism. When released, the compression member may be driven downwards to compress the proximal compartment so as to break the frangible seal and allow the diluent to mix with the drug powder and form a liquid drug mixture, and then to eject the liquid drug mixture from the reservoir.

The present invention provides a method for generating an immune response in a subject, comprising administering to the subject's skin an immunizing composition from a SARS-CoV-2 pathogen, wherein the composition is administered with a microneedle delivery device.

The invention discloses a closed-loop artificial pancreas device with integrated detection and infusion, comprising: infusion unit configured to deliver drugs; program unit comprising input end and output end, and the input end comprises a plurality of electrically connective regions for receiving signals of analyte data in the body fluid, after the output end is electrically connected to the infusion unit, according to the received signals of analyte data in the body fluid, the program unit controls whether the infusion unit delivers drugs; an infusion cannula with conductive area, the infusion cannula is the drug infusion channel; and a plurality of electrodes for detecting analyte data in body fluid, the electrode comprising conductive-area electrode and cannula-wall electrode, the conductive area of the infusion cannula being at least as a conductive-area electrode, and one or more cannula-wall electrodes being located on/in the wall of the infusion cannula.

A unilaterally driven drug infusion device with multiple infusion modes includes a reservoir, a piston, a screw, a driving unit, at least one driving wheel provided with teeth, a linear actuator, a reset unit, and a control unit. The piston is arranged in the reservoir. The driving unit includes a rotating shaft and a driving member, and the driving member includes a driving end. The linear actuator and the reset unit are respectively connected to the driving member. The control unit controls the linear actuator or the reset unit to apply different driving powers on the driving member to make the driving member have a variety of different operating modes.