A fluid delivery device comprises a fluid reservoir for containing medicament. The fluid reservoir is sealed proximate one end with a sliding seal piston. A delivery path is configured to fluidly couple the fluid reservoir and a patient wearing the fluid delivery device. A basal engine mechanism is configured to directly or indirectly move the sliding seal piston in the fluid reservoir at a controlled basal rate. A bolus mechanism configured to move the basal engine relative to the fluid reservoir and directly or indirectly move the sliding seal piston in the fluid reservoir a discrete bolus amount at a time.

Devices and methods are provided for delivering fluid into a patient's body. In an exemplary embodiment, the device may include a syringe cartridge and a syringe driver that may be coupled to the cartridge. The cartridge may include a housing including a proximal end, a distal end, and defining an interior, the cartridge further including a piston slidably disposed within the interior for delivering fluid within the interior through a port in the distal end. The driver may include a plunger for advancing the piston within the interior of the housing, a source of pressurized fluid, a valve, and an actuator member coupled to the valve for selectively opening a flow path from the source to the plunger to control flow of the pressurized fluid to advance the plunger to deliver fluid from the interior of the housing at a desired rate.

A fluid pumping system may include an electroosmotic pump; and a separation member provided at least one end of the electroosmotic pump, and configured to separate the fluid and a transfer target fluid. The electroosmotic pump may include: a membrane that allows a fluid to move therethrough; and a first electrode and a second electrode which are respectively provided at two opposite sides of the membrane, and each of which is formed of a porous material or has a porous structure to allow a fluid to move therethrough; each of the first electrode and the second electrode may be made of porous carbon only; and an electrochemical reaction of the first electrode and the second electrode may take place as a cation is moved in a direction whereby a charge balance is established.

A fluid delivery device comprises a drive unit including an actuator and one or more first features and a cartridge filled with a fluid prior to being inserted into the housing. The cartridge having a fluid reservoir sealed at one end by a movable piston and sealed at another end by a pierceable septum. The cartridge includes one or more second features that are configured to align and mate with the one or more first features allowing the cartridge to be inserted into the drive unit. The piston is moveable by the actuator once the cartridge is inserted into the drive unit.

Exemplary embodiments provide wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates, for example, in a single bolus. Exemplary embodiments provide methods for assembling wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates. Exemplary embodiments provide methods for using wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates.

The present invention relates to a method of determining a system compressibility value of a medical membrane pump drive, wherein a first and second pressure level are moved to and a first and second operating parameter value of the membrane pump drive are detected; wherein the system compressibility value is determined on the basis of the detected operating parameter values; and wherein the membrane of the membrane pump drive is supported at a rigid surface during the determination of the system compressibility value.

An osmotic actuator (110) for a wearable injection device (100) is disclosed, which osmotic actuator comprises a pressure chamber (150) having one or more outlets (152) and containing a draw solution containing dissolved inorganic salt, one or more osmotic membranes (130), and a cavity (140) containing water, and wherein the one or more osmotic membranes (130) form at least a part of one or more internal surfaces of the pressure chamber (150), wherein the water is in contact with at least a part of one or more external surfaces of the one or more osmotic membranes (130), and wherein the dissolved inorganic salt in the draw solution comprises one or more of the following: CaBr.sub.2, CaCl.sub.2, ZnBr.sub.2, ZnCl.sub.2, ZnI.sub.2 or LiBr. Furthermore, a wearable injection device (100) comprising such an osmotic actuator (110) and the use of such inorganic salts in a draw solution are disclosed.

A fluid pumping system may include an electroosmotic pump; and a separation member provided at least one end of the electroosmotic pump, and configured to separate the fluid and a transfer target fluid. The electroosmotic pump may include: a membrane that allows a fluid to move therethrough; and a first electrode and a second electrode which are respectively provided at two opposite sides of the membrane, and each of which is formed of a porous material or has a porous structure to allow a fluid to move therethrough; each of the first electrode and the second electrode may contain a conductive polymer in which an anionic polymer is included or may be made of porous carbon only; and an electrochemical reaction of the first electrode and the second electrode may take place as a cation is moved in a direction whereby a charge balance is established.

Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.

This invention relates to local administration of a bone-forming agent and at least one anti-resorptive agent to treat osteoporosis and related disorders.