A syringe propellable by propellant that boils at a predetermined temperature, the syringe including a barrel having an outlet at a front end, and a stopper axially moveable in the barrel. The stopper separates a first chamber and a second chamber, the first chamber being axially forwards of the stopper and being configured for containing a medicament, and the second chamber being axially rearwards of the stopper and being configured to receive propellant for acting on the stopper to move the stopper axially forwardly in the barrel to expel medicament through the outlet upon actuation of the syringe. The syringe further includes a third chamber for containing propellant. Upon actuation of the syringe, liquid propellant is released from the third chamber and boils outside of the third chamber at or above the predetermined temperature to provide an increasing vapor pressure in the second chamber that causes the stopper to move axially forwardly and begin to expel medicament through the outlet. At least one trigger for triggering an action is provided, the trigger activated in response to the pressure in the second chamber satisfying a predetermined condition.

An osmotic actuator (110) for an injection device (100) is disclosed, which osmotic actuator (110) comprises a pressure chamber (180; 280; 380) having one or more outlets (182; 282; 295; 395) and containing a draw solution, one or more osmotic membranes (130), a cavity (140) containing water, and a dilution-compensating arrangement, wherein the one or more osmotic membranes (130) forms a part of an internal surface area of the pressure chamber (180; 280; 380), wherein the cavity (140) containing water abuts at least part of an external surface of the one or more osmotic membranes (130), and wherein the dilution-compensating arrangement is arranged to compensate for the dilution of the draw solution near the one or more osmotic membranes (130), which occurs when water from the cavity (140) enters the pressure chamber (180; 280; 380) through the one or more osmotic membranes (130). Furthermore, an injection device (100) comprising such an osmotic actuator (110) is disclosed.

This invention relates to isolated polypeptides that are glucagon-receptor selective analogs and peptide derivatives thereof. These analogs are selective for human glucagon receptor with improved solubility, thermal stability, and physicochemical properties as compared to native endogenous glucagon. This invention also relates to methods of using such polypeptides in a variety of therapeutic and diagnostic indications, as well as methods of producing such polypeptides. These analogs are useful, alone or in combination with other therapeutic peptides, in methods of treating obesity, diabetes, metabolic disorders, and other disorders or disease.

A medication infusion device includes a pre-filled medication container containing sterile liquid medication. The medication infusion device also includes an infusion needle and the infusion needle has a distal end, wherein the distal end of the infusion needle is movable relative to the pre-filled medication container. There is a pierceable elastomeric component arranged at the distal end of the infusion needle to define a sterile environment, and this sterile environment is shared by the pre-filled medication container and the distal end of the infusion needle. The distal end of the infusion needle is embedded in a pierceable elastomeric component in order to keep the infusion needle enclosed in the sterile environment and prevent medication from flowing out of the infusion needle.

Exemplary embodiments provide wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates, for example, in a single bolus. Exemplary embodiments provide methods for assembling wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates. Exemplary embodiments provide methods for using wearable automatic injection devices for subcutaneously injecting a therapeutic agent into a patient's body at controlled rates.

An apparatus for injecting an infusion solution is provided, and the apparatus includes a housing including a receiving part to receive an infusion solution bag in the receiving part and an infusion solution tube connected with the infusion solution bag and withdrawn, and a pressing member received in the receiving part to self-inflate as air is supplied and to press the infusion solution bag.

A device for the administration of liquids, drugs,. or nutrients to a patient includes a deformable bag for containing a liquid, a drug, or a nutrient to be administered, in fluid communication, through a tube, with a needle, or a tube, or a catheter that can be inserted in a patient.

The device includes an expandable air container whose expansion generates the compression of the deformable bag, a compressed air generation component adapted to introduce air into the expandable air container, a first proportional valve associated with the tube. The valve is configured to regulate the flow of the liquid, drug, or nutrient from the deformable bag generated by the compression of the bag due to expansion of the expandable air container, and a control unit connected to the valve configured to control operation of the valve according to parameters of administration of the liquid, drug, or nutrient to the patient.

The present disclosure relates to a portable pressure container for driving a medical device. The container includes a pressure housing confining an interior volume and a pressure outlet extending through the pressure housing . The interior volume comprises a liquid storage portion and a gas storage portion. The liquid storage portion and the gas storage portion are in flow connection with each other. The liquid storage portion is configured to store a liquid phase of a driving medium. The gas storage portion is configured to store a gas phase of the driving medium. The pressure outlet is only in flow connection with the gas storage portion.

Automated drug delivery systems and related methods are disclosed herein. In some embodiments, these systems can reduce or eliminate infusion inconsistencies. An exemplary system can include a syringe actuator which can be controlled via electrical, mechanical, pneumatic, and/or hydraulic means to precisely infuse and/or withdraw material from a patient.

A medical fluid infusion system includes a peristaltic pump system configured to deliver a fluid drug to a patient. The peristaltic pump system can include a peristaltic pump in communication with a pressure source. In some embodiments, the peristaltic pump system can include a valve body positioned between the peristaltic pump and pressure source for controlling the delivery of pressurized fluid (e.g., air, liquid) to the peristaltic pump. The peristaltic pump can include more than one occluder, with each occluder having a flexible member that can form a collapsed and extended configuration based on a pressure provided to the flexible member.