An invention directed to an implant device having a biointerface. The implant device comprises a cavity and a structure enabling a flow path between the cavity and an environment of the implant device. An actuatable membrane is interposed in the flow path. The device includes a power-generating unit and a control unit, where the latter is connected to the power-generating unit. An electromechanical is connected to both the control unit and the power-generating unit. The electromechanical system includes at least one actuator configured to mechanically contact the membrane. This actuator is permanently attached to the membrane. The control unit and the electromechanical system are jointly configured to cause the electromechanical system to controllably actuate the membrane via at least one actuator to control a transfer of substances between the cavity and the environment through the flow path. The invention is further directed to related operation and fabrication methods.

Disclosed are examples of reservoir and reservoir systems usable with a wearable drug delivery device. An example reservoir may include a flexible component coupled to a shell component. The shell component may include drainage channels to facilitate extraction of the liquid drug from the reservoir. A reservoir system example may include an exoskeleton configured around a flexible reservoir to guide the expansion and collapse of the flexible reservoir. Alternatively, one or more rigid panels may be coupled to corresponding flat surfaces of the flexible reservoir to guide the expansion and collapse of the flexible reservoir. A further reservoir example may include a flexible thin film reservoir having peel-able restraints configured to seal off corresponding sections of the reservoir, sequentially break, enabling the liquid drug to sequentially fill corresponding sections in a controlled and predicable manner. A wearable drug delivery device example suitable for utilizing the described examples is provided.

An engagement mechanism associated with a reciprocally movable piston of a fluid injector is configured for releasably engaging an engagement portion at a proximal end of a rolling diaphragm syringe having a flexible sidewall configured for rolling upon itself when acted upon by the piston. The engagement mechanism has a plurality of engagement elements reversibly and pivotally movable about a pivot pin relative to the engagement portion of the syringe between a first position, where the plurality of engagement elements are disengaged from the engagement portion of the syringe, and a second position, where the plurality of engagement elements are pivotally movable about the pivot pin in a radially inward direction to engage with the engagement portion of the syringe. The engagement mechanism further has a drive mechanism for moving the plurality of engagement elements between the first position and the second position.

A system and method for correcting a volume of fluid delivered by a fluid injector during an injection procedure is described. The method included determining and compensating for a volume factor associated with compliance of the fluid injector system and correcting for the volume by one of over-driving the distance that the drive member travels in a fluid reservoir, under-driving the distance that the drive member travels in the fluid reservoir, or lengthening or shortening a fluid delivery time.

Disclosed in some embodiments is an electronic intravenous infusion pump provided with a disposable, insertable pump cartridge that is connectable to one or more intravenous fluid infusion sources, wherein a user interface on a touch display screen interacts with and responds to the user's insertion of the cassette, and/or wherein the pump is enabled to program a course of infusion for a patient based upon information obtained from the inserted cassette and/or the one or more fluid infusion sources connected to the cassette.

A patch-sized fluid delivery device may include a reusable portion and a disposable portion. The disposable portion may include components that come into contact with the fluid, while the reusable portion may include only components that do not come into contact with the fluid. Redundant systems, such as redundant controllers, power sources, motor actuators, and alarms, may be provided. Alternatively or additionally, certain components can be multi-functional, such a microphones and loudspeakers that may be used for both acoustic volume sensing and for other functions and a coil that may be used as both an inductive coupler for a battery recharger and an antenna for a wireless transceiver. Various types of network interfaces may be provided in order to allow for remote control and monitoring of the device.

An infusion cassette of an infusion set is provided with a flow channel, and includes a rigid assembly, elastic membranes and a locking mechanism. The rigid assembly includes a plurality of components stacked onto one another, at least one of the components is provided with a groove, and the elastic membranes are each arranged between two adjacent components to cover the groove in a sealing manner; and the locking mechanism includes a mounting frame and a liquid stop plug fixedly arranged on the mounting frame, and configured to press the elastic membranes to close the flow channel, the locking mechanism closes or opens the flow channel by the liquid stop plug. The mounting frame is movably connected to the rigid assembly, such that the locking mechanism is switched between a closed state in which the flow channel is closed and an open state in which the flow channel is opened.

Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made during a “priming” stage when liquid is pumped through the internal fluid path but does not exit the pump.

An infusion pump comprises an elastomeric hemispheric deformable rolling diaphragm, an external rigid housing with internal area no greater than that of the rolling diaphragm exterior, and a rigid cap structure which sealingly fastens the rim of the rolling diaphragm to the rim of the external housing. Thickness of the flexing wall of the diaphragm is tapered from rim to a region on the central axis to provide approximately constant pressure as the pump empties its contents. The rigid housing has an port in its center opposite its rim to allow insertion of fluid to roll the diaphragm inward, and to allow outflow of the stored pressurized fluid as desired. The housing and/or cap structure may have an external belt mounting fixture to facilitate donning the infusion pump for ambulatory users. The simplified design enables low manufacturing cost and hence single-use disposability.

A drug delivery device, including a body having a reservoir disposed therein for containing a medicament, the reservoir including a flexible wall; a plunger movable within the body for causing the medicament to be expelled from the reservoir, the plunger having a contact surface that is not affixed to said flexible reservoir wall; a spring biasing the plunger toward the reservoir; and means for selectively maintaining the plunger in a pre-activated position with respect to the reservoir and, upon releasing the plunger from the pre-activated position, for guiding the plunger to move under the force of the spring such that the contact surface of the plunger contacts the flexible reservoir wall to pressurize the reservoir for delivery of the medicament to a patient.