Gas-powered fluid injection systems and methods are disclosed, e.g., for delivering fluids into a patient's body. An injection device comprises a driver housing which forms and/or encloses a gas pressure source, an actuation piston driven by the gas pressure source and a hydraulic fluid pressurized by movement of the actuation piston. The hydraulic fluid flows through an adjustable valve into a plunger lumen which pushes a plunger of a fluid dispensing device, such as a syringe, to dispense an injection fluid, such as a medicament. The injection device has a movable plunger sleeve which receives the plunger of the fluid dispensing device. The plunger sleeve is moved during the activation and de-activation of the injection device such that it relieves residual pressure in the fluid dispensing device thereby preventing the fluid dispensing device from continuing to dispense injection fluid after the injection device has been de-actuated.

Gas-powered fluid injection systems and methods are disclosed, e.g., for delivering fluids into a patient's body. An injection device comprises a driver housing which forms and/or encloses a gas pressure source, an actuation piston driven by the gas pressure source and a hydraulic fluid pressurized by movement of the actuation piston. The hydraulic fluid flows through an adjustable valve into a plunger lumen which pushes a plunger of a fluid dispensing device, such as a syringe, to dispense an injection fluid, such as a medicament. The injection device has a movable plunger sleeve which receives the plunger of the fluid dispensing device. The plunger sleeve is moved during the activation and de-activation of the injection device such that it relieves residual pressure in the fluid dispensing device thereby preventing the fluid dispensing device from continuing to dispense injection fluid after the injection device has been de-actuated.

A method for controlling the flow rate of a pneumatic syringe in a system that includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes one or more syringes, while the reusable hardware includes a syringe pump for each syringe of the disposable fluid circuit and a controller. The syringe pump includes a vacuum/pressure source for moving the piston within the syringe and a position detector for indicating the position of the piston within the syringe. The method controls several distinct phases of the process: break pressure targeting, glide control and vent control, and the method is the same regardless of whether a positive pressure or a vacuum is applied to the piston of the syringe. Preferably, a proportional-integral-derivative (PID) feedback loop is used for controlling the movement of the piston in the syringe.

A delivery system configured to be secured on a patient skin which comprises a first container having a first variable volume; a second container having a second variable volume; and a skin adherable unit configured to secure the first container and the second container to the patient skin. The medical device may further comprise a containers' interface configured to operatively couple the first container and the second container such that a volume increase of the second variable volume may induce a volume decrease of the first variable volume. Preferentially, the system further comprises a vent device configured to prevent any unintended pressure increase in the first storage compartment.

A delivery system configured to be secured on a patient skin which comprises a first container having a first variable volume; a second container having a second variable volume; and a skin adherable unit configured to secure the first container and the second container to the patient skin. The medical device may further comprise a containers' interface configured to operatively couple the first container and the second container such that a volume increase of the second variable volume may induce a volume decrease of the first variable volume. Preferentially, the system further comprises a vent device configured to prevent any unintended pressure increase in the first storage compartment.

A fluid dispensing device is provided for dispensing a measured amount of fluid into a living organism. The device includes a rigid fluid reservoir closed by a septum for use in a fluid dispensing device for dispensing a measured amount of fluid into a living organism, wherein the device has a main housing enclosing the operative components of the device, the said fluid reservoir located within the main housing, an injection assembly including a needle, and a trigger mechanism. The needle has a first end adapted to piercing the septum and pushing the septum into the reservoir so that the septum acts as a piston, expelling the fluid through the needle, and a second end adapted to injecting the fluid into the living organism.

A treatment system configured to treat a disease using a first therapeutic fluid, the treatment system including a base housing, a first reservoir configured to store a first therapeutic fluid disposed within the base housing, a first plunger disposed within the first reservoir, a first rotatable shaft member configured to rotate within the base housing, and a first flexible member having a first end coupled to the first plunger and a second end coupled to the first rotatable shaft member, wherein the first rotatable shaft member is configured to shorten a length of the first flexible member to deliver the first therapeutic fluid from the first reservoir.

A treatment system configured to treat a disease using a first therapeutic fluid, the treatment system including a base housing, a first reservoir configured to store a first therapeutic fluid disposed within the base housing, a first plunger disposed within the first reservoir, a first rotatable shaft member configured to rotate within the base housing, and a first flexible member having a first end coupled to the first plunger and a second end coupled to the first rotatable shaft member, wherein the first rotatable shaft member is configured to shorten a length of the first flexible member to deliver the first therapeutic fluid from the first reservoir.

An apparatus and method for the aseptic delivery of a biologic medication in a wearable form factor. The apparatus and method allow for standard off-the-shelf drug cartridges to be utilized without compromising the sterility of the biologic. Further, by utilizing a two part assembly, manufacturing costs are minimized.

The present embodiments provide systems and methods suitable for delivering a therapeutic agent to a target site. A container holds the therapeutic agent and a pressure source has pressurized fluid in selective fluid communication with at least a portion of the container. A catheter, in fluid communication with the container, has a lumen sized for delivery of the therapeutic agent to a target site. In one embodiment, a diameter of particles of the therapeutic agent is in a range of between about 1 micron to about 925 microns, a mass of the particles of the therapeutic agent is in a range of between about 0.0001 mg to about 0.5 mg, a ratio of an inner diameter of the catheter to the diameter of particles is at least 4:1, and a regulated pressure of the pressurized fluid is between about 0.01 psi to about 100 psi.