An apparatus for performing a vascular treatment is disclosed. In some embodiments, the apparatus comprises two modules that are maintained in separate zones of an operating environment. The apparatus includes an elongate, intraluminal member that is shaped and dimensioned for passage through blood vessels of a subject. The intraluminal member has a proximal end and a distal end. A vein wall disruptor for degrading the integrity of the inner wall of a vessel is housed within a sheath of the intraluminal member. The disruptor includes at least one, but may include several, prongs. The distal ends of the prongs contact or communicate with the inner wall of a blood vessel. The disruptor can include a contacting tip designed to damage the interior of the vessel as the disruptor is pulled proximally therealong. The apparatus further includes an automatic injector to inject a sclerosant into the blood vessel.

An apparatus for performing a vascular treatment is disclosed. In some embodiments, the apparatus comprises two modules that are maintained in separate zones of an operating environment. The apparatus includes an elongate, intraluminal member that is shaped and dimensioned for passage through blood vessels of a subject. The intraluminal member has a proximal end and a distal end. A vein wall disruptor for degrading the integrity of the inner wall of a vessel is housed within a sheath of the intraluminal member. The disruptor includes at least one, but may include several, prongs. The distal ends of the prongs contact or communicate with the inner wall of a blood vessel. The disruptor can include a contacting tip designed to damage the interior of the vessel as the disruptor is pulled proximally therealong. The apparatus further includes an automatic injector to inject a sclerosant into the blood vessel.

Fluid delivery and measurement systems and methods are disclosed.

Fluid delivery and measurement systems and methods are disclosed.

Devices, systems, and methods for inflation are provided. Inflation devices include a housing, a compressed gas canister disposed therein, a syringe disposed within the housing, a plunger slidably disposed in the syringe having an unloaded position and a loaded position relative to the syringe, a puncture mechanism disposed within the housing and configured to open a fluid path between the compressed gas canister and the syringe, and a positive pressure mechanism disposed within the housing and operably coupled to the syringe. Engagement of the puncture mechanism puts the syringe into fluid communication with the compressed gas canister such that gas contained therein loads into the syringe and the plunger moves from the unloaded position and the loaded position. The positive pressure mechanism is configured to maintain the gas within the syringe at a positive pressure relative to ambient pressure in order to prevent air from entering the syringe after loading.

A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.

A fluid delivery device comprises a hydraulic pump chamber having a hydraulic fluid. A fluid reservoir is coupled to the hydraulic pump chamber and is configured to contain a fluid deliverable to a patient. A first actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir. A second actuator is coupled to the hydraulic pump chamber and is configured to pressurize the hydraulic pump chamber and configured to transfer energy through the hydraulic pump chamber to the fluid reservoir.

In one aspect the present disclosure refers to a measuring arrangement for measuring of a volume change of a liquid medium located inside a liquid reservoir, the measuring arrangement comprising: a gas tight enclosure having an interior volume containing a gas reservoir and containing the liquid reservoir, wherein the liquid reservoir is filled with a liquid medium, a gas inlet in flow connection with the gas reservoir and extending through a boundary of the gas tight enclosure to an exterior of the gas tight enclosure, an outlet connectable with the liquid reservoir and extending through the boundary of the gas tight enclosure, wherein the gas reservoir and the liquid reservoir are hermetically separated by an impenetrable separation wall, and a flow meter arranged in or across the gas inlet to measure an ingress of a gaseous medium through the inlet in response to a withdrawal of the liquid medium from the liquid reservoir through the outlet.

In one aspect the present disclosure refers to a measuring arrangement for measuring of a volume change of a liquid medium located inside a liquid reservoir, the measuring arrangement comprising: a gas tight enclosure having an interior volume containing a gas reservoir and containing the liquid reservoir, wherein the liquid reservoir is filled with a liquid medium, a gas inlet in flow connection with the gas reservoir and extending through a boundary of the gas tight enclosure to an exterior of the gas tight enclosure, an outlet connectable with the liquid reservoir and extending through the boundary of the gas tight enclosure, wherein the gas reservoir and the liquid reservoir are hermetically separated by an impenetrable separation wall, and a flow meter arranged in or across the gas inlet to measure an ingress of a gaseous medium through the inlet in response to a withdrawal of the liquid medium from the liquid reservoir through the outlet.

An implantable drug delivery device and method that includes a sensor device for detecting deflection of a diaphragm at a first time from a first position within a diaphragm chamber of an accumulator of the implantable drug delivery device. A cycle count may be incremented in response to the diaphragm returning to the first position within the diaphragm chamber, each time during cyclical deflections within the diaphragm chamber. A flow rate of infusate may be determined based on a volume of the diaphragm chamber, the cycle count, and an elapsed time since the first time. Once the flow rate is determined, a processor may determine whether the flow rate of infusate is normal based on a comparison of the determined flow rate to at least one threshold flow rate.