Cellular therapy infusion devices for the delivery of media including cellular therapies to a patient's tissue, cells, and/or blood include a barrel, a plunger that fits within the barrel, a syringe shaft, and a pressure relief system configured to achieve and/or maintain a desired level of pressure and/or force within the device so that cellular behavior and/or viability is not adversely impacted by the mechanical forces exerted thereon via depressing the plunger into the barrel so the cellular therapy media may be pushed from the barrel into a patient delivery device for administration to the patient. The cellular therapy infusion devices may cooperate with and/or fit into cellular therapy infusion systems designed to create and/or maintain preferred conditions for the cellular therapy media stored in the barrel and automatically administer the cellular therapy media from the cellular therapy infusion device to the patient in a steady, regulated, and/or preferred manner.

A fluid sensing apparatus and method for detecting pressure and the presence of bubbles within a fluid tube. The fluid sensor comprises a housing configured to receive a portion of the tube and to house the pressure sensor and the ultrasonic transmitter. The pressure sensor is positioned adjacent the tube and is configured to receive a pressure sensor signal, which correlates to a detected pressure differential within the tube. A controller transmits a drive signal to the ultrasonic transmitter, which emits ultrasonic waves through a portion of the tube and to the pressure sensor. The pressure sensor receives both the ultrasonic waves and a pressure sensor signal, and subsequently transmits an output signal to the controller. In the presence of a pressure differential or a bubble within the tube, the output signal will exhibit a DC shift or a distortion of its signal characteristics, respectively.

Methods for setting up, maintaining and operating a radiopharmaceutical infusion system, that includes a radioisotope generator, are facilitated by a computer of the system. The computer may include pre-programmed instructions and a computer interface, for interaction with a user of the system, for example, in order to track contained volumes of eluant and/or eluate, and/or to track time from completion of an elution performed by the system, and/or to calculate one or more system and/or injection parameters for quality control, and/or to perform purges of the system, and/or to facilitate diagnostic imaging.

A method for determining a volume of one or more air bubbles in a fluid path includes initiating an injection procedure in which at least one medical fluid is injected into the fluid path, receiving an electrical signal from an air detector of the fluid injector system, wherein the electrical signal indicates the presence of one or more air bubbles in the fluid path, calculating a flow rate of fluid in the fluid path, determining a fluid pressure in the fluid path, determining a count value of the one or more air bubbles representative of a volume of the one or more air bubbles, and updating a cumulative counter with the count value of the one or more air bubbles. The cumulative counter is representative of a cumulative volume of air that has passed through the fluid path during the injection procedure.

Syringe pump controllers which memorialize the process of hydrodynamic isotonic saline delivery (HIFD) to reverse acute kidney injury are disclosed. In some embodiments, the syringe pump controllers are constructed to control syringe pump(s) to deliver a defined volume of saline at a prescribed perfusion rate while monitoring renal vein pressures during the infusion. In some embodiments, the syringe pump controllers have safety features designed to shut off the infusion if the renal vein pressure goes above set safety limits.

A system for delivering a medicinal fluid to a patient includes a variable volume pressure delivery chamber, a variable volume medication chamber, an optional medication reservoir, a movable delivery element, a fixed reference volume chamber, a pressure source, and a control sub-system. The variable volume pressure delivery chamber is configured to store pressure controllably. The variable volume medication chamber is fluidically isolated from the pressure delivery chamber and is configured to store medicinal fluid. The movable delivery element is disposed between the medication chamber and the pressure delivery chamber. The pressure source is coupled to the pressure delivery chamber. The control system is configured to selectively cause the pressure source to deliver pressure to the pressure delivery chamber causing the movable delivery element to apply pressure to the medicinal fluid in the medication chamber thereby causing the medicinal fluid to exit the medication chamber at an outlet along the fluid communication path to the patient.

A system and method removing air from a reservoir, the system comprising the reservoir that carries a medicament, a first pump connected to the reservoir that draws the medicament out of the reservoir, an air removal device connected to the first pump that releases air from the medicament, and a second pump connected to the air removal device that delivers the medicament.

A medicament delivery device having a reservoir for holding a medicament, a pressurizing system that dispenses the medicament from the reservoir when operating, a hollow cannula for insertion into a patient, and a fluid delivery path disposed between the pressurizing system and the hollow cannula and communicating the medicament therebetween. The medicament delivery device also has a pressure sensor external to the pressurizing system, sensing a back pressure in the fluid delivery path, and providing an indication when the back pressure drops below a predetermined threshold after the pressurizing system ceases operation.

A method of determining the status of a fluid cooled microwave ablation system is provided including providing an electrical current to a pump to pump fluid through an ablation system along a fluid path to cool the ablation system, measuring an electrical current drawn by the pump, and determining a status of the ablation system based on the measured electrical current. In another aspect of the disclosure, an ablation system is provided including an ablation probe defining a fluid path for circulation of fluid therethrough, a generator configured to supply energy to the ablation probe for treating tissue, a pump configured to pump fluid through the fluid path of the ablation probe to cool the ablation probe, a sensor configured to measure an electrical current drawn by the pump, and a computing device configured to determine a status of the ablation system based on the measured electrical current.

Embodiments of the present invention utilize a closed-loop feedback control system to ensure accurate drug delivery. This control system may, for example, utilize a flow sensor to measure the volume of delivery and an intelligent control algorithm to anticipate and compensate for overdoses and underdoses. Feedback control systems in accordance herewith can be applied to any piston- or plunger-driven pump system utilizing sensors that measure flow directly or indirectly. In some embodiments, adjustments are made during a “priming” stage when liquid is pumped through the internal fluid path but does not exit the pump.