A medicament delivery device (100) for delivery of medicament through a cannula (132) from a cartridge (10). The device comprises a first container (11) for storage of a first substance, a second container (12), and valve means for closing a distal end of the second chamber (12). The second container (12) is arranged coaxially with respect to the first container (11). A mixing element (304) is provided for causing displacement of the second substance into the first container (11) through the valve means in a mixing stroke. A release element (202) is provided for holding the mixing element (304) in an initial position and is operable to release the mixing element (304) to initiate the mixing stroke. There is a needle shroud (400) for shrouding the cannula, and removal of the needle shroud (400) from the cannula (132) causes operation of the release element (202).

An auto-injector for administering a dose of a liquid medicament includes a tubular chassis telescopable in an elongate chassis, a carrier subassembly including a tubular carrier slidably arranged partially inside the chassis and inside the case, the carrier adapted to contain a syringe with a hollow injection needle, a drive spring, a plunger for forwarding load of the drive spring to a stopper of the syringe, a control spring arranged around the carrier, a needle insertion control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis, wherein the syringe is lockable for joint axial translation with the carrier, wherein the needle insertion control mechanism includes a first collar biased by the control spring in a proximal direction, and wherein at least one fifth clip is arranged on one of the chassis or the first collar.

Container assemblies for accommodating pharmaceutical compositions are provided. The container assembly includes a container and a plunger. The container has a hollow cylindrical body with an open end and a closed end, which is closed by a bottom portion. The hollow cylindrical body has a length (L), an outer diameter (DO), and an inner diameter with a length to outer diameter ratio between 3:1 and 15:1. The hollow cylindrical body and the bottom portion are formed integrally and of the same material, which is a glass or polymer material. The container has an inner surface with an average Zn-leachability of 0.00085 ?g/cm.sup.2 or less. The plunger is inside the hollow cylindrical body at the open end, is pierceable by a cannula, and is slidable relative to the hollow cylindrical body from the open end towards the closed end.

An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

Plunger systems for expelling a liquid drug from a drug container within a wearable drug delivery device are provided. A rotation system coupled to a plunger rotates the plunger about a central axis of the plunger to overcome a static friction between the plunger and the drug container. After rotating the plunger, a drive system moves the plunger forward into the drug container to expel the liquid drug for delivery to the patient. A collapsible plunger includes a cavity. A radial torsion spring positioned in the cavity can provide an outward radial force on the collapsible plunger. The cavity enables the collapsible plunger to compress radially when entering and passing through a region of a drug container having a relatively narrower width. The radial torsion spring can radially expand the collapsible plunger when entering and passing through a region of the drug container having a relatively wider width.

This device is intended to receive an injection syringe. The injection syringe has: a syringe body, a piston mounted slidably in the syringe body, and an injection needle fixed to a distal end of the syringe body. The automatic injection device includes a piston control member, which is displaceable in translation with respect to the syringe body, parallel to an axis X, in order to control the displacement of the piston in the syringe body, a piston rod intended to push a proximal end of the piston of the injection syringe, releasable coupling means for coupling the piston control member and the piston rod, an injection spring which bears on the piston control member and elastically stresses the piston control member towards a distal end of the injection needle. The releasable coupling means are positioned axially between the two axial ends of the injection spring.

A storage and mixing device includes a mixing compartment, two pistons that each extend from the mixing compartment and end in a displacement section, each piston defining a passageway having a first opening communicating with the mixing compartment and a second opening communicating with an inlet at the displacement section, and a housing having two piston guides and a cartridge compartment connected to the piston guide, each piston guide slidably receiving one of the pistons, and each cartridge compartment receiving a removable cartridge that includes a cavity for containing separate substances and an opening sealed by a cartridge seal. The displacement section of each piston includes a piercing member for piercing the cartridge seal of the cartridge arranged in the corresponding cartridge compartment, such that the displacement section enters the cartridge cavity and displaces the contained substance into the mixing compartment via the inlet and the passageway.

A medicinal xiding vial, and a dispensing apparatus and an injection apparatus thereof, comprise a reversely pressed medicinal xiding vial, a reversely pressed dispensing apparatus and a reversely pressed injection apparatus thereof, a general medicinal xiding vial, and a general injection apparatus. The reversely pressed medicinal xiding vial comprises a vial body whose inner wall is a straight cylinder. A first piston is disposed on a position close to the vial opening of the vial body. A blind hole is disposed at the center of an outer bottom surface of the first piston. The vial opening is provided with an outer edge, and a seal cap is fixed on the out edge to prevent the first piston from falling off. In combination with the dispensing apparatus and the injection apparatus thereof, the medicinal xiding vial can solve the problem of secondary pollution during medicine dispensing and injection.

The invention relates to a wearable injection device (1) for subcutaneous injection of a therapeutic agent, wherein the dose is injected over a specified period of time after the device is activated.

A pen injector apparatus is disclosed for use with a cartridge to deliver a plurality of single metered doses therefrom. The injector apparatus includes a body arranged to provide a conduit which, in use, provides a fluid communication path between the cartridge and a delivery needle and a mechanism arranged to expel therapeutic material from the cartridge. The mechanism is arranged to draw therapeutic material from the cartridge into the conduit by negative pressure and discharge a metered dose from the conduit via the delivery needle.