Plunger systems for expelling a liquid drug from a drug container within a wearable drug delivery device are provided. A rotation system coupled to a plunger rotates the plunger about a central axis of the plunger to overcome a static friction between the plunger and the drug container. After rotating the plunger, a drive system moves the plunger forward into the drug container to expel the liquid drug for delivery to the patient. A collapsible plunger includes a cavity. A radial torsion spring positioned in the cavity can provide an outward radial force on the collapsible plunger. The cavity enables the collapsible plunger to compress radially when entering and passing through a region of a drug container having a relatively narrower width. The radial torsion spring can radially expand the collapsible plunger when entering and passing through a region of the drug container having a relatively wider width.

In some examples, a vial-to-syringe converter includes a plunger rod, an adapter including a body having a piercing spike, a receiver and a lumen extending between the spike and the receiver, the body further including at least one laterally-extending flange, and a needle in communication with the receiver and configured to deliver a medicament to a patient's body.

The invention relates to an auto-injector (1) for administering a dose of a liquid medicament (M), comprising: a tubular chassis (2) telescopable in an elongate chassis (12), a carrier subassembly comprising a tubular carrier (7) slidably arranged partially inside the chassis (2) and inside the case (12), the carrier (7) adapted to contain a syringe (3) with a hollow injection needle (4), a drive spring (8) and a plunger (9) for forwarding load of the drive spring (8) to a stopper (6) of the syringe (3), wherein the syringe (3) is lockable for joint axial translation with the carrier (7), a control spring (19) arranged around the carrier (7), a needle insertion control mechanism (24) for coupling a proximal end of the control spring (19) to either the carrier (7) for advancing it for needle insertion or to the chassis (2),
wherein the needle insertion control mechanism (24) comprises a first collar (20) biased by the control spring in a proximal direction (P), wherein at least one fifth clip (2.10) is arranged on one of the chassis (2) or the first collar (20) initially abutting a block (20.7) on the other of the chassis (2) or the first collar (20), wherein a ramped engagement between the fifth clip (2.10) and the carrier (7) is provided for outwardly deflecting the fifth clip (2.10) on translation of the carrier (7) in the proximal direction (P), wherein outward deflection of the fifth clip (2.10) and translation of the carrier (7) in the proximal direction (P) is initially prevented by the case (12) outwardly abutting the fifth clip (2.10), wherein the case (12) is at least initially biased in the distal direction (D), wherein the case (12) is arranged to translate against the bias in the proximal direction (P) relative to the chassis (2) into an advanced position thereby translating a second window (12.8) in the case (12) outwardly behind the fifth clip (2.10) thus allowing outward deflection so as to decouple the fifth clip (2.10) from the block (20.7) and to allow the first collar (20) to abut against the carrier (7) and advance it under load of the control spring (19).

A device for retaining and storing a liquid medium, such as medication, includes a syringe body, a retention and/or storage container, consisting essentially of a glass material, a closure element for the retention and/or storage container consisting essentially of a rubber elastic material, and at least one needle. The retention and/or storage container is a vial having a solid bottom and a pushing device is provided to move the vial in a substantially axial direction in the syringe body, the pushing device acting upon the solid bottom of the vial.

A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.

An auto-injector for administering a dose of a liquid medicament (M) is presented having a tubular chassis telescopable in an elongate chassis, a carrier subassembly comprising a tubular carrier slidably arranged partially inside the chassis and inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. The auto-injector also has a control spring arranged around the carrier, a needle insertion control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis, wherein the needle insertion control mechanism comprises a first collar biased by the control spring in a proximal direction (P), wherein at least one fifth clip is arranged on one of the chassis or the first collar initially abutting a block on the other of the chassis or the first collar.

A syringe for use with a medical ampoule and/or a medical vial, the syringe haying: (a) a syringe body; (b) a syringe plunger having a hollow interior volume which is open at one end; and (c) an ampoule interface element configured for deployment between an outer surface of the ampoule and the surface of the hollow interior volume so as to hold the medical ampoule in the hollow interior volume. A method for the use of the syringe is also disclosed.

A wearable injection device for subcutaneous injection of a therapeutic agent, wherein the dose is injected over a specified period of time after the device is activated.

A mechanically operable handpiece is provided which allows a physician to easily deliver repeated, incremental doses of a beneficial composition, for example, a dermal filler gel, superficially into skin.

A sealant delivery system includes a syringe assembly having side-by-side syringes and a vial assembly having side-by-side vials. A first vial is aligned with a distal end of a first syringe and has a vial opening at the proximal end thereof that is closed by a first sealing membrane. A second vial is aligned with a distal end of a second syringe and has a second vial opening at the proximal end thereof that is closed by a second sealing membrane. The vial assembly includes a first piercing element moveable between a retracted position and an extended position for piercing the first sealing membrane to provide fluid communication between the first fluid chamber and the first vial, and a second piercing element moveable between a retracted position and an extended position for piercing the second sealing membrane to provide fluid communication between the second fluid chamber and the second vial.