Medical device assemblies capable of aspirating liquid into a syringe barrel or other medical devices while evacuating any air from the syringe are described. An exemplary medical device includes a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within either the stopper or the plunger rod. Described is a medical device including a syringe barrel, plunger rod and stopper assembly having an air permeable and liquid impermeable porous portion and structure for forming a vacuum within chamber between the stopper and plunger rod wherein the plunger rod includes a sealing edge and is moveable relative to the stopper. Exemplary medical devices may include a vent for allowing air that permeates through the porous portion to escape to atmosphere. Methods for aspirating a syringe barrel with a liquid are also provided.

A needle unit (20) comprising: a needle hub (21) comprising a needle (23) and a needle shield (22), wherein the needle hub (21) and the needle shield (22) are arranged to form a needle unit (20) where the needle hub is arranged displaceably inside the needle shield such that the needle hub is displaceable along an axis which is parallel with the longitudinal axis of the needle (23) between a shielded position and an exposed position. The needle hub (21) further comprises a first hub locking element (24) and a second hub locking element (26) and the needle shield (22) further comprises a first shield locking element (25) and a second shield locking element (27), said first hub locking element (24) and said first shield locking element (25) engaging each other in the shielded position to establish a first releasable locking mechanism (24, 25) between the needle hub (21) and the needle shield (22), said second hub locking element (26) and said second shield locking element (27) engaging each other in the shielded position to establish a second locking mechanism (26, 27) between the needle hub (21) and the needle shield (22), both the first and second locking mechanisms (24, 25, 26, 27) being arranged as shock proof locks, and where the first releasable lock mechanism (24, 25) is arranged to engage with the lock release element (31) of the injection device (1) when the needle unit (20) is coupled to the injection device, said engagement allowing the first releasable lock mechanism (24, 25) to be unlocked. The invention further provides an injection device comprising the needle unit and a method of assembling an injection device with the needle unit.

A cartridge holder assembly is provided, comprising an enclosed cartridge, a distal portion and a proximal portion. The enclosed cartridge defines a longitudinal axis and comprises a generally cylindrical main portion, a distal outlet portion having a neck portion with a circumferential shoulder portion, and a proximal portion having an opening surrounded by a circumferential rim. The distal portion comprises a distal support structure engaging the cartridge neck portion and being adapted to support the cartridge against movement in the distal direction, and the proximal portion comprises a proximal support structure engaging the cartridge circumferential rim and being adapted to support the cartridge against movement in the proximal direction. The proximal support structure is essentially non-deformed, and the distal support structure engaging the cartridge neck portion is plastically deformed.

A cap assembly for a medicament delivery device having a housing and a medicament container holder. The cap assembly includes a retainer member connectable to the container holder; a hub having a needle and coaxially movable within the retainer member; an inner cap connected to the hub and the retainer member; an outer cap coaxially arranged to the inner cap; and a cap clutch mechanism having a locking member that is axially movable in relation to the inner and outer caps between a disengaged position, in which the outer cap is rotatable relative to the inner cap, and an engaged position, in which the outer cap is rotationally locked to the inner cap. The cap clutch mechanism also has a clutch biasing device arranged between the outer cap and the locking member for biasing the locking member for keeping it in the disengaged position.

The present invention relates to a torsion spring based automatic injection device for apportioning set doses of a liquid drug and which injection device is provided with an End-of-Dose feedback mechanism providing a user with an audible signal once the set dose has been injected. During injection, the scale drum rotates back to its “zero” position under influence of the torsion spring. This rotation is halted shortly before reaching the “zero” position by stopping means. The scale drum is thereafter only allowed to continue rotation and thus reach the “zero” position once the torque applied to the scale drum by the torsion spring surpasses a threshold value.

According to the invention there is provided a needle assembly (1) for mounting on an injection device. The needle assembly comprises; a main body (10) configured to be removably attached to the injection device in use and a needle (90) is secured in the main body (10) having a forward portion which projects forwardly from the main body. A shield (60) is pivotally connected with the body portion by a hinge portion (80). The shield (80) is rotatably movable between: a first position, in which the forward portion of the needle (90) is exposed for use, and a second position, in which the shield (60) is positioned over the forward portion of the needle (90) such that the forward portion of the needle is substantially enclosed within the shield. The shield (60) comprises a pair of spaced apart side walls (64, 66). The base of the side walls comprise a first cooperating feature (72, 74) for engaging a second cooperating feature (22, 24) of the main body (10). The cooperating features are configured to engage to hold the shield in its second position independently of the hinge.

A cassette is disclosed for receiving a medicament container, the cassette having a medicament delivery member; a guard for covering the medicament delivery member; a shell movable between a proximal shell position where movement of the guard is prevented by the shell, and a distal shell position where the guard is exposed from the shell; a biasing device arranged to force the shell towards the distal shell position; a blocking device movable from a blocking position where the shell is blocked from moving to the distal shell position, to a releasing position where the shell is released; and a locking device movable from a first position to a second position; wherein the blocking device and the locking device are arranged such that movement of the locking device from the first position to the second position causes the blocking device to move from the blocking position to the releasing position.

An autoinjector (100′) for expelling a single dose of a drug from a held cartridge (600) comprising a piston (630). The autoinjector includes a needle shield (350, 380′) axially movable from an initial extended position via a triggering position to a trigger release position. The needle shield (350, 380′) is operatively coupled to a plunger release element (320′, 1320) cooperating with a plunger (310, 400) to define a releasable retaining mechanism that retains the plunger release element (320′, 1320) threadedly engaged with a base thread component (204′, 1204) in a predefined relative rotational and axial position and against rotational bias provided by an actuator (330). The needle shield (350, 380′) is configured for operating the retaining mechanism to release the retaining of the plunger release element (320′, 1320) and the base thread component (204′, 1204) from the predefined relative rotational and axial position upon the needle shield (350, 380′) being moved into the trigger release position.

The present disclosure relates to an injection needle assembly for use in a medicament delivery device. The injection needle assembly comprises an injection needle holder, an injection needle fixed to said injection needle holder, the injection needle having a proximal end and a distal end, and a sealing assembly for sealing the distal end of the injection needle. The sealing assembly comprises a spacer element surrounding the distal end of the injection needle and a sealing membrane for sealing the distal end of the injection needle.

The invention relates to an activating mechanism for a medicament delivery device (1), comprising: —an outer body (8), —a cartridge (2) containing a dosage of a medicament and sealed with a sealing element (2.1) that is arranged across an open distal end of the cartridge (2), —a cartridge carrier (4) adapted to hold the cartridge (2), —a needle safety mechanism adapted to hold a double-ended hollow needle (6) and to relatively move along a longitudinal axis (L) with respect to the cartridge (2) and to the outer body (8) to cover or to expose the needle (6), —wherein in an initial position (P1) of the medicament delivery device (1), the double-ended hollow needle (6) is spaced from the cartridge (2) in a distal direction (D), and —wherein when the needle safety mechanism is pressed into the outer body (8), a proximal end of the needle (6) pierces the sealing element (2.1). The invention further relates to a medicament delivery device (1) comprising such an activating mechanism.