Implementations of the present disclosure are directed to a sealing of a medicament reservoir for a drug delivery device. The drug delivery device includes a reservoir, a stopper and a sealing system. The reservoir includes a wall defining a distal end, a proximal end, and a proximal closure. The stopper is configured to expel a portion of a medicament stored within the reservoir by moving within the reservoir in a direction from the distal end to the proximal end, such that a stopper position is indicative of an amount of the medicament within the reservoir. The sealing system is configured to form a liquid tight seal between the proximal closure and the injection needles such that expelling the portion of the medicament comprises directing substantially all of the portion of the medicament from the reservoir into the injection needles.

A fluid delivery device comprises a drive unit including an actuator and one or more first features and a cartridge filled with a fluid prior to being inserted into the housing. The cartridge having a fluid reservoir sealed at one end by a movable piston and sealed at another end by a pierceable septum. The cartridge includes one or more second features that are configured to align and mate with the one or more first features allowing the cartridge to be inserted into the drive unit. The piston is moveable by the actuator once the cartridge is inserted into the drive unit.

An autoinjector is described that includes an outer body, a first trigger, an output needle, and a first compartment. The first compartment is positioned within the outer body and includes (i) a main body, (ii) a first biasing member coupled to the first trigger, and (iii) a protrusion positioned at a distal end of the main body. The autoinjector further includes a second compartment positioned in the outer body and in fluid communication with the first compartment and the output needle. The autoinjector also includes a second biasing member coupled to a second trigger. The first biasing member is configured to, upon application of force to the first trigger, automatically move an ampule in a distal direction relative to the main body to force the ampule against the protrusion, so as to break the ampule and allow a medicament to flow from the ampule to the second compartment.

Injection device comprising an elongated body (1) with a hollow needle (8) at a distal end; a reservoir for an injection material to be delivered through the needle; a plunger (3) with a first force element (5) configured to provide an injection force to said injection material, and a distal element (10) attached to the distal end of the device thereby sealing a needle lumen, wherein the distal element comprises a tissue interface and a distal seal (11), and wherein the distal seal is penetrable by a distal tip of the needle by the application of pressure on a tissue surface with the distal end of the device, wherein the penetrated distal element becomes slidable on the needle to allow advancement of the needle into tissue, wherein the penetrated distal seal opens a path for flow or delivery of the injection material from the distal end of the needle.

A needle tip (22) for being connected and disconnected in use from a needle tip support (16), comprises a needle (24) having a forward end and a rearward end and, a connector secured to the needle intermediate its ends. The connector comprises two arms (28) each extending outwardly and rearwardly relative to the needle (16) and configured to be coupled and uncoupled in use from said needle tip support, and the arms are disposed on opposite sides of the needle. Also disclosed are arrangements for storing, dispensing and later disposing such needle tips, as well as coupling interfaces between the needle tip and a needle support cap to which it is fitted in use.

Add-on module (100) for logging the value of an expelled dose from a pen-type drug injector (200), comprising a magnetic sensor system comprising first and second sensor means (745/746) as well as a mechanical dose setting and expelling mechanism comprising a magnetic clutch element (240/740) which rotates during drug expelling. The system further comprises processor means configured to determine (i) on the basis of measured values from the first sensor means, a rotational position of the clutch element, (ii) on the basis of measured values from the second sensor means, a high-speed condition in which the rotational speed of the clutch element exceeds a given threshold level, and (iii) indicate an error state if the high-speed condition is detected.

Devices and methods for the ab interno delivery of two or more fluid compositions into Schlemm's canal through a single insertion point in the eye with minimal trauma. The hand-held delivery device includes a handle coupled to an elongated shaft that terminates in a self-trephinating tip through which one or more cannulae are slidably disposed and can be extended or retracted therethrough. The handle further defines a chamber for receiving one or more cartridges each containing at least one fluid composition. Each cartridge is fluidly connected to a respective cannula such that sequential actuation of each cartridge causes dispensation of the fluid compositions at the site for delivery without having to repeatedly enter the target site multiple times. Ab interno methods for localized delivery of a fluid composition into Schlemm's canal are further described.

A portable handheld fluid-medicine-injection device for individual users, has a medicine vial has a substantially rectangular cross section that reduces a thickness profile of the device and a dispense mechanism coupled with the vial, the dispense mechanism has an inject push rod inside a threaded cylinder that reduces a length profile of the device. The device has a needle with a needle mount/dismount mechanism coupled with the medicine vial and a needle storage mechanism that stores the needle when not in use and replenishes the needle for reuse.

A medicament packaging assembly for installation in a medicament delivery device is disclosed. The packaging assembly comprises a cartridge having a medicament chamber, a sealing element for sealing a distal end of the medicament chamber, a sealing element release member, a cannula and a removable cap member. The assembly is switchable from a starting configuration in which the release member is spaced from the sealing element to an activated configuration in which the release member cooperates with the sealing element to connect the medicament chamber to the cannula. The packaging assembly further comprises a first chamber defined in part by the cap member and arranged for receiving the cannula such that at least a distal end of the cannula is sealed in the first chamber when the cap member is in place, and a second chamber defined in part by the sealing element and arranged for receiving the release member such that at least a proximal end of the release member is sealed in the second chamber when the assembly is in the starting configuration. The assembly can be pre-assembled in the starting configuration for subsequent installation in the device.

A discharger for discharging a predetermined amount of fluid from a separate container including a discharge section defining a longitudinal axis and having a proximal end and a distal end and having a discharge passage for the fluid extending between an inlet opening and an outlet opening of the discharge section. The discharger further includes an intermediate section including a distal portion cooperating with the proximal end of the discharge section and a proximal portion defining a receiving space which is adapted to be loaded with the separate container holding an amount of fluid to be discharged by the discharger. The distal portion and the proximal portion are formed in one piece and are interconnected by a breakable section.