A gas sterilizable syringe includes an enclosure having walls that define a fluid chamber. A flowable material is disposed within the fluid chamber of the enclosure. A plunger is assembled with the enclosure and is moveable toward a distal end of the enclosure for dispensing the flowable material. One or more apertures are formed in at least one of the walls of the enclosure. A gas permeable barrier covers at least one of the apertures formed in at least one of the walls of the enclosure for enabling sterilization gases to pass through the at least one aperture covered by the gas permeable barrier while preventing the flowable material from passing through the at least one of aperture. The gas permeable barrier is permeable to the sterilization gases and impermeable to the flowable material disposed within the fluid chamber of the enclosure.

A cap for a pre-filled syringe with a Luer-lock connector including a main body provided with a first handle portion and a second portion designed to be coupled to the Luer-lock connector, an axial cavity having an aperture at the second coupling portion formed in the main body; and a rubber housed within the axial cavity of said main body. The cap also includes a tapered portion, which is interposed between the first handle portion and the second coupling portion and is designed to air-tightly engage the Luer-lock connector, and the rubber has a surface facing the aperture of the axial cavity, the surface being designed to abut against an open free end of a tip of the pre-filled syringe for air-tightly closing the open free end.

Disclosed is a method of sealing a syringe barrel having a syringe tip with a collar. The syringe tip is sealed with a resilient closure. A tamper evident syringe tip cap comprising a cap member and a sleeve member separated by an annular first breaking line is then pushed over the resilient closure, to couple the proximal end of the sleeve member with the collar. The distal end of the resilient closure is accommodated in the cap member and protrudes beyond the sleeve member. The first breaking line is bridged by a coupling strip. For use of the syringe and providing access to the closure, the first breaking line is broken by pivoting the cap member away. The sleeve member remains coupled to the collar. Further tearing the cap member downward causes breaking a second breaking line provided in the sleeve member, thereby enabling removing the entire syringe tip cap.

A tip cap for a medical injection device, including: a tip connector configured to engage a tip of the medical injection device; a closure cap configured to sealingly close a distal opening of the tip, the closure cap being releasably connected to the tip connector; an RFID tag including a chip and an antenna, where the chip is overmolded in one of the tip connector and the closure cap and the antenna is overmolded in the other one of the tip connector and the closure cap, the chip and the antenna being electrically connected by a bridge configured to break under a relative movement applied to the closure cap and the tip connector in order to release the closure cap from the tip connector, and the antenna is located at an interface between the tip connector and the closure cap.

An injection device including a syringe including a barrel having a distal end and a proximal end and a tip provided on the distal end of the barrel, the barrel defining an internal bore extending from the proximal end to the distal end of the barrel; a luer lock adaptor including a body having a proximal end and a distal end, a reduced-diameter portion provided on the proximal end of the body, and a threading provided on an outer surface of the body, the reduced-diameter portion defining an opening to receive the tip of the syringe in a friction fit; and a needle hub including a body defining an inner cavity, a needle receiving portion extending distally from the body, and a skirt extending inwardly into the inner cavity.

An object of the present invention is to provide a medical rubber composition having excellent non-elution characteristic and gas permeability. The present invention provides a medical rubber composition containing: (a) a butyl rubber, (b) a diene-based rubber containing polybutadiene, (c) a peroxide-based crosslinking agent, and (d) a co-crosslinking agent, wherein an amount of (b) the diene-based rubber in 100 parts by mass of the rubber component composed of (a) the butyl rubber and (b) the diene-based rubber is 15 parts by mass or more and 90 parts by mass or less, and a mass ratio ((d)/(c)) of (d) the co-crosslinking agent to (c) the peroxide-based crosslinking agent is 1.2 or more and 25 or less.

Methods and apparatus to reduce deadspace in syringes and other devices with the use of volume displacing members that occupy space within one or more interior spaces of such devices. The volume displacing members are also equipped with one or more internal flow passages that facilitate a flow of a fluid through it. The volume displacing members are also adapted to cooperate with features of the devices that house them to form air-tight and liquid-tight seals that at least partially determine a fluid pathway through the devices.

A prepackaged injectable pharmaceutical composition includes a sealed outer package made of a material having a low oxygen transmission rate and an inner package disposed within the sealed outer package. The inner package is configured to provide an indication that the inner package has been opened after being closed. A prefilled syringe is disposed within the inner package. The syringe includes a barrel comprising a polymeric material and a dose of the injectable pharmaceutical composition.

A cap assembly includes an access member including a first section and a second section. The first section includes a connection portion that is attachable to an extraction device that extracts contents of a reservoir. The connection portion includes a first opening. The second section includes a second opening in fluid communication with the contents of the reservoir when the access member is secured to the reservoir. The cap assembly includes a valve member insertable into the access member so as to be in fluid communication with the first opening and the second opening and such that the valve member i) seals the contents of the reservoir at the first opening when the connection portion is not attached the extraction device, and ii) provides access to the contents of the reservoir through the first opening when the connection portion is attached to the extraction device.

In a syringe, which is a prefilled syringe, when a cap body is attached to a cylindrical portion, a first sealing section is compressed radially inward by an inner peripheral surface constituting an opening of the cylindrical portion, thereby sealing a distal end section of a flow path in a liquid-tight manner, and a second sealing section is compressed radially inward by an inner peripheral surface of a proximal end section of the cylindrical portion, thereby sealing a proximal end section of the flow path in a liquid-tight manner.