A syringe assembly of a prefilled syringe includes a syringe cap. A tapered section of a second tubular section constituting this cap has, on an outer peripheral surface of the tapered section, a plurality of stepped sections continuously arranged along a center axis of a cover member, so as to gradually increase a protruding amount of the tapered section from an outer peripheral surface of an annular peripheral wall section toward a vicinity of an outer edge of an opening of a first tubular section.

An assembly for a drug delivery device comprises a housing, a dose member which is displaceable in a proximal direction with respect to the housing for setting of a dose of a drug, a clutch member which is displaced in the proximal direction with respect to the housing when setting the dose, and a stop member configured to define a clutch stop position. The clutch member and the dose member are configured to mechanically cooperate with one another when the clutch member is in the clutch stop position, thereby preventing further displacement of the dose member in the proximal direction with respect to the housing during setting of the dose.

Syringe tip caps are described herein. Such syringe tip caps may include a cup, a cap, a locking feature, a peelable seal and an absorbent material. The cap having locking features and a chamber appropriately sized to adapt to and interlock with an annular wall of the cup.

A syringe assembly may include a plunger having a stopper. A barrel may be configured to receive the plunger at an open first end. A tip cap may be removably attached to the second end and may form a chamber within the barrel between the plunger and tip cap. The chamber may be configured to contain a sterilization sensitive material. The barrel may be formed of a plastic material having a high barrier property configured to create a barrier between the sterilization sensitive material and gases produced for sterilization purposes such that the sterilization sensitive material remains unchanged during a sterilization procedure.

A syringe assembly including: (1) a syringe barrel defining a chamber; (2) a plunger mounted in the chamber and moveable with respect to the barrel; and (3) a cap holder assembly containing a cap and an absorbent material removably attached to the syringe.

A syringe system includes a first syringe, a second syringe, and at least any one of a first buoy located inside a first syringe barrel or a second buoy located inside a second syringe barrel. The first syringe includes the first syringe barrel. The second syringe includes the second syringe barrel coupled to the first syringe in such a manner that at least part of the second syringe barrel is movable from inside the first syringe barrel.

A closure assembly for a medical dispenser which may include a one-piece tip cap having a flow restrictor and a removably connected sleeve disposed in surrounding relation to the flow restrictor. The tip cap further includes an access opening and an oppositely disposed closed end, wherein the flow restrictor is structured for a fluid sealing engagement with a discharge port of the medical dispenser, passing through said access opening. The closed end includes removably attached inner and outer end segments respectively formed on the flow restrictor and the sleeve and are collectively structured to define a removable connection between the flow restrictor and sleeve. A cover may be fixedly attached to the sleeve in overlying, covering relation to exterior surfaces of the inner and outer end segments.

A method of preparing a prefilled syringe (1), comprises (i) obtaining a syringe barrel (11) having an open end (111) and a tip (112) with an orifice (113) essentially opposite to the open end (111), and a needle adaptor cap (12) assembled on the tip (112) of the syringe barrel, wherein the needle adaptor cap (12) has a rubber element (121) tightly sealing the orifice (113) of the tip (112) of the syringe barrel (11) and the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) is sterilized by a first sterilizing comprising a main step of exposing the syringe barrel (11) together with the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 5 hours to about 60 hours at a relative humidity of about 40% to about 100% and at a temperature of about 30° C. to about 60° C.; (ii) filling a drug substance (14) through the open end (111) of the syringe barrel (11) into an interior of the syringe barrel; (iii) sealing the interior of the syringe barrel (11) by advancing a rubber stopper (13) through the open end (111) of the syringe barrel (11); (iv) packaging the syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11); and (v) second external surface sterilizing the packaged syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11). The rubber element (121) of the needle adaptor cap (12) and the rubber stopper (13) are made of a rubber material having a comparably low oxygen transmission rate such as, at 1 atmosphere, of not more than 64 cubic centimeter per square meter and day. The second external surface sterilizing comprises a main step of exposing the packaged syringe barrel (11) together with the rubber stopper (13) sealing the interior of the syringe barrel (11) and the needle adaptor cap (12) assembled on the tip (112) of the syringe barrel (11) to ethylene oxide for about 3 hours to about 30 hours at a relative humidity of about 40% to about 100% and at a temperature of about 25° C. to about 45° C. At least one of the duration, the relat

A cartridge for use with a beneficial agent delivery device having a tillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments and a fitment. The first compartment contains at least a first constituent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the tillable reservoir.

A cap assembly includes an access member including a first section and a second section. The first section includes a connection portion that is attachable to an extraction device that extracts contents of a reservoir. The connection portion includes a first opening. The second section includes a second opening in fluid communication with the contents of the reservoir when the access member is secured to the reservoir. The cap assembly includes a valve member insertable into the access member so as to be in fluid communication with the first opening and the second opening and such that the valve member i) seals the contents of the reservoir at the first opening when the connection portion is not attached the extraction device, and ii) provides access to the contents of the reservoir through the first opening when the connection portion is attached to the extraction device.