Described are improvements to components of fluid transfer apparatuses comprising a first component, e.g. a syringe, a connector component configured to connect between the first component and an adapter component that is configured to allow connection of the connector component to a second component of the drug transfer apparatus, e.g. to a drug vial. The improvements include inter alia changes to the sealing elements that seal the proximal end of the syringe, redesign of a septum holder inside the connector component and corresponding redesign of the housing of the connector component; changes to the structure of the end of the connector component that connects to the first component to allow the first component to swivel relative to the connector component; and changes to the design of the adapter component to a second component of the drug transfer apparatus to allow it to mate with the redesigned housing of the connector component.

An injection device configured for attachment to the skin of a patient using an adhesive layer includes a release liner covering the adhesive layer thereby preventing skin attachment. The release liner comprises a sheet of material where a first surface contacts the adhesive layer, and an aperture defining a passage for a film connected to a first sterile barrier film located within the injection device. An end of the film is connected to a second surface of the sheet of material that is opposite to the first surface, and the release liner is covered by a strengthening sheet connected to the second surface and covering the aperture and the end of the film.

An injection device configured for attachment to the skin of a patient includes a housing and a skin adhesive layer attached to an external surface of the housing for attaching the injection device to the skin of a patient. A release liner covering the skin adhesive layer prevents the injection device from attaching to the skin. A film with one end connected to a surface inside of the housing forms a removable sterile barrier and the other end connected to an external surface of the release liner without contacting the skin adhesive layer. The housing, skin adhesive layer and release liner each include a notch defining a passage for the film so that the second end of the film can extend from the interior to the exterior of the housing.

A protection device for a needle comprising an inner casing defining a cavity and an outer casing surrounding the inner casing, wherein the outer casing is provided with stabilizing means capable of cooperating with a substantially horizontal surface of a support so as to maintain the inner casing in a substantially vertical direction, in which an access to the cavity is left free. An assembly comprising such a protection device and a needle fixed on the needle tip of a drug delivery device.

The invention discloses a sterile syringe (100) comprising a barrel (1) having internal surfaces (2), a plunger (3) movable within the barrel, a non-sliding seal (7) between the barrel and the plunger defining a sealed volume (8) and at least one filter (9) allowing only filtered gases to enter the sealed volume such that the syringe maintains its sterility even after several uses. The filters could be positioned on different locations on the syringe like on the non-sliding seal, the barrel, the barrel flange or the plunger handle.

The invention provides a syringe for dispensing a drug (1), comprising: a rigid syringe body, a first container (2), in contact with and enclosing the drug; and a second container (3), enclosing the first container, the second container being less gas permeable than the first container, wherein the second container partially or fully forms the rigid syringe body or is held within the rigid syringe body. The invention preserves the drug but allows the drug to be easily accessed without the need for a user to remove a gas barrier structure as a separate action in addition to the other actions needed to deliver the drug.

Disclosed are plunger assemblies including various convertible plungers and methods of making the same. Each plunger assembly is configured for disposition within a barrel of a medical container, e.g., a syringe, and displaced within the barrel from an engagement position to a release position. The engagement position is configured to provide a compression seal between a storage sealing section of the plunger and an inner wall of the syringe barrel. In the release position, the compression seal is reduced or eliminated. Also disclosed are methods for making convertible plungers and as assembling them into syringes, e.g., pre-filled syringes.

Vented syringes are described herein. A vented syringe includes a syringe body and a plunger body. The syringe body defines a syringe cavity. The plunger body is at least partially disposed within the syringe cavity. The plunger body includes an air intake channel defined within the plunger body. The vented syringe further includes a plunger seal that is sealingly engaged with the syringe cavity to cooperatively define a syringe volume. The vented syringe further includes a one-way valve in fluid communication with the air intake channel and the syringe volume, wherein the one-way valve is configured to prevent fluid flow from the syringe volume to the air intake channel and permit fluid flow from the air intake channel to the syringe volume.

A needle cover assembly can be used with a medicament delivery device, wherein said needle cover assembly is disposable and comprises a retainer element connectable to a medicament container holder; a hub having a longitudinal axis and comprising a double pointed injection needle with a proximal needle end and a distal needle end, wherein the proximal needle end projects a distance from the hub along the longitudinal axis, and a shield covering at least the proximal needle end and a portion of the hub. Said shield comprises a detachable element, that the shield is attached to the hub when said detachable element is attached to the shield, corresponding to an untampered state, and that the shield is released and is telescopically movable in relation to the hub along the longitudinal axis when said detachable element is detached from the shield corresponding to an activated state.

In an embodiment, an injection simulation device is provided. The injection simulation device may include a housing defining an opening, the housing having a proximal end and a distal end, a plunger movable relative to the housing, the plunger comprising a first interfacing portion, and distal movement of the plunger initiates an injection simulation, a rotatable component comprising a proximal end and a distal end, and an aperture extending between the proximal and distal ends of the rotatable component for receiving a portion of the plunger, rotatable component comprising a second interfacing portion for interfacing with the first interfacing portion to rotate the rotatable component when the plunger is moved toward the proximal or distal end of the housing. The injection simulation device may further include a stationary component defining a cavity for receiving the rotatable component, the cavity comprising a fluid, wherein movement of the plunger causes rotational and axial movement of the rotatable component, such that an interface between the rotatable component and the stationary component causes an increase in resistance during distal movement of the plunger, and a decrease in resistance occurs upon proximal movement of the plunger.