Vented syringes are described herein. A vented syringe includes a syringe body and a plunger body. The syringe body defines a syringe cavity. The plunger body is at least partially disposed within the syringe cavity. The plunger body includes an air intake channel defined within the plunger body. The vented syringe further includes a plunger seal that is sealingly engaged with the syringe cavity to cooperatively define a syringe volume. The vented syringe further includes a one-way valve in fluid communication with the air intake channel and the syringe volume, wherein the one-way valve is configured to prevent fluid flow from the syringe volume to the air intake channel and permit fluid flow from the air intake channel to the syringe volume.

A syringe includes a plunger having a plunger tube with proximal and distal ends, a center tube with a center passage that extends within the plunger tube, and a balloon disposed over the center tube and sealingly fixed to at least one of the center tube and the plunger tube. The syringe also includes a barrel having a barrel tube having proximal and distal ends and an interior configured to accept a portion of the plunger, a tip fixedly coupled to the proximal end of the barrel tube, a post fixedly attached to the tip and extending within the barrel tube toward the distal end, the tip configured to partially extend into the center passage of the plunger, and a gas passage extending from a proximal end of the tip to the distal end of the post.

Disclosed are plunger assemblies including various convertible plungers and methods of making the same. Each plunger assembly is configured for disposition within a barrel of a medical container, e.g., a syringe, and displaced within the barrel from an engagement position to a release position. The engagement position is configured to provide a compression seal between a storage sealing section of the plunger and an inner wall of the syringe barrel. In the release position, the compression seal is reduced or eliminated. Also disclosed are methods for making convertible plungers and assembling them into syringes, e.g., pre-filled syringes.

Implementations of an applicator syringe are provided. In some implementations, the applicator syringe may be configured to dispense a lubricant from a dispensing needle thereof. In some implementations, the applicator syringe may be configured so that the plunger shaft and the dispensing needle are removable when not in use. In some implementations, when the applicator syringe has been disassembled, the dispensing needle may be stored within the barrel of the applicator syringe and the plunger shaft secured about the exterior of the barrel. In some implementations, the applicator syringe may comprise a barrel having a finger flange, a plunger positioned within the interior chamber of the barrel, a plunger shaft configured to urge the plunger forward, a dispensing needle that can be removably secured to the front end of the barrel, a removable cap, and a barrel plug.

There is provided drug delivery devices comprising a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

A syringe assembly for use as a pre-filled syringe is disclosed. The syringe assembly includes a syringe barrel defining a chamber and having a stopper disposed therein. A plunger rod includes an inner member engaged with a portion of the stopper and an outer member adapted for rotational advancement with respect to the inner member to axially displace the outer member with respect to the inner member. The plunger rod is transitionable from a collapsed position in which a portion of the inner member is nested within the outer member, to an extended position in which the same portion of the inner member extends outside the outer member. The inner member includes a radial extension and the outer member defines a helical track adapted to receive the radial extension therein.

A medical syringe includes a ratchet for use during dispensing. The medical syringe, by virtue of the ratchet, enables repeated dispensing of a fixed amount of a relatively high-viscosity fluid to a target site within a patient. The medical syringe may be pre-filled with fluid and the fluid maybe sealed within the medical syringe. Accordingly, the medical syringe is configured to resist leaks and/or breaches that may occur as a result of manufacturing, sterilization, shipping, and/or storage.

There is provided drug delivery devices including a drug container assembly with a needle and automatic needle insertion and drug delivery mechanisms. Aspects of the devices described include a noise-generation mechanism to indicate the completion of drug delivery, a mechanism for triggering drug delivery following needle insertion, front-end activation of the device and a safety mechanism for covering the needle after use and methods of assembly of the devices.

An injection device configured for attachment to the skin of a patient using an adhesive layer includes a release liner covering the adhesive layer thereby preventing skin attachment. The release liner comprises a sheet of material where a first surface contacts the adhesive layer, and an aperture defining a passage for a film connected to a first sterile barrier film located within the injection device. An end of the film is connected to a second surface of the sheet of material that is opposite to the first surface, and the release liner is covered by a strengthening sheet connected to the second surface and covering the aperture and the end of the film.

An intravascular port access device includes a first component having a chamber configured to attach reversibly to an intravenous line port. A second component reversibly attaches to the first component and contains a disinfecting agent and an applicator material. The second component is configured to be reversibly received over external surfaces of the intravenous line port. A method of cleansing an intravenous line port includes providing a port cleaning device having a first component with a chamber containing a first cleaning agent. A second component includes a second cleaning agent. A third component has a microbicidal agent and is reversibly attached to the first component. The second component is removed from the device, the external surfaces of the port are contacted with the second cleaning agent, the first cleaning agent is ejected from the chamber into the port, and the third component is used to cap the port.