The present invention relates to a prefilled plastic container, such as a plastic syringe, comprising an aqueous botulinum toxin formulation. The aqueous botulinum toxin formulation in the prefilled plastic container is stable for a prolonged time period. Furthermore, the present invention relates to a kit comprising the prefilled plastic container, and to the use of the prefilled plastic container for therapeutic and cosmetic purposes.

An article or vessel is described including a vessel surface and a coating set comprising at least one tie coating, at least one barrier coating, and at least one pH protective coating. For example, the coating set can comprise a tie coating, a barrier coating, a pH protective coating and a second barrier coating; and in the presence of a fluid composition, the fluid contacting surface is the barrier coating or layer. The respective coatings can be applied by PECVD of a polysiloxane precursor. Such vessels can have a coated interior portion containing a fluid with a pH of 4 to 8. The barrier coating prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating and pH protective coating together protect the barrier layer from the contents of the vessel. The second barrier coating is comparable to glass surface if needed.

A pre-filled pharmaceutical package comprising a liquid formulation of a VEGF-antagonist, for example Ranibizumab, in a pre-filled pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. Stability performance of the VEGF-antagonist packaged in the coated COP vessel comparable to or better than glass was obtained.

A sealed medication dispensing and administering device has a syringe, a plunger, a connecting holder, an elastic valve, and a liquid stopper. The syringe has an outer barrel having an air inlet tube and an inner barrel inserted inside the outer barrel and having a medication inlet tube. The plunger is inserted within the outer and inner barrels. The connecting holder is connected to the syringe and has a connecting cover with at least one outer connecting hole and two piercing needles respectively piercing inside the air inlet tube and the medication inlet tube. Inner spaces of the two piercing needles communicate with the at least one outer connecting hole. The elastic valve selectively covers the two piercing needles. The fluid stopper is disposed within the connecting cover and blocks one of the at least one outer connecting hole and the inner space of the air inlet tube.

A telescoping syringe suitable for use with medications and other materials is presented. The telescoping syringe includes a valve, a plunger, and a barrel. The valve further includes a barrier, an outlet(s) through the barrier, and an annular extension extending from the barrier. The plunger further includes an inlet(s) and a first side wall with a proximal wall. The barrel includes a second side wall with a distal wall at one end and an open end at another end. The plunger is extendable from and retractable into the barrel at the open end via slidable engagement between first and second walls. The valve directly contacts one end of the first wall so that an annular flange slidingly engages an annular groove. The valve and the barrel slidingly contact the plunger so as to open and to close the inlet(s) and/or the outlet(s). The inlet(s) in the open position permits gas to enter a first reservoir within the plunger as fluid is transferred from the first reservoir through the outlet(s) in the open position to a second reservoir within the barrel.

The present application relates to pressure sensors for injection devices. According to a first aspect, the specification discloses an injection device comprising: a medicament container comprising medicament container walls and a sealing element; a stopper translatably disposed inside the medicament container; a pressure sensor; and a plunger passing through an axial bore of the sealing element, the plunger being operable to displace the stopper, wherein the sealing element, stopper and medicament container walls define a cavity inside the medicament container; and wherein the pressure sensor is configured to measure the pressure inside the cavity during an injection.

A device for the needle tube of a syringe includes a housing which can pivot on a carrier element for the needle tube and which has an open housing side in the pivoting plane of the housing such that the needle tube can be swung into the housing in order to be held there after being used for injection. The arrangement of the rear free end of the needle tube in the carrier element enables controlled piercing, of the all of a container that is replaceable in the carrier element.

A pre-filled syringe includes a barrel with a medicament and a stopper within the barrel. The stopper has at least two adjacent sealing rings and a trim ring. The syringe has a head space distance between a distal-most surface of the stopper and the surface of the medicament. The head space (a) provides sufficient space to optimize reconstituting a drug suspension by shaking or agitating the drug suspension, and (b) minimizes frothing and/or clogging of the reconstituted drug suspension in the barrel. Also, a kit includes the syringe, a plunger, a syringe cap, and a needle assembly. Further, a method for stoppering the syringe includes determining the head space distance.

A safety syringe includes an outer barrel having a receiving groove located on an inner surface of a rear end thereof between a first annular flange and a second annular flange, an inner barrel having a needle mount located on a front end thereof and a positioning portion adjacent to the needle mount, and a plunger axially movably inserted into the inside of the inner barrel.

A needle and pre-filled syringe system that provides ultra-low dosage waste and automatic needlestick protection. A syringe assembly is pre-filled with an injection material. A needle head assembly attaches to the syringe assembly. A spacer is disposed between the needle head assembly and the syringe assembly. The spacer has a central opening. The needle head assembly supports a needle with a needle base. When assembled, the needle base passed into the central opening of the spacer. The needle head assembly also contains a safety slide that can selectively cover the needle. During an injection, pressure and/or contact with the plunger head causes the spacer to contact and move the safety slide. The safety slide moves to cover the needle during the injection procedure, therein rendering the needle safe before the injection process is even complete.