A container having a barrier layer is provided. The container may be of thermoplastic and the barrier may inhibit materials from leaching from the thermoplastic material or from extraction of compounds from medicants by the thermoplastic. A process is also described that allows for molding thin barrier layers as container lines and for forming thermoplastic containers with barrier liners.

A liquid formulation of an ophthalmic drug in a pharmaceutical package, for example a syringe, cartridge, or vial, made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer.

Coatings for syringe plunger tips, as well as syringes and syringe components including such coatings, are disclosed. A material of the coating may have at least one different material property than a material of the syringe component to which it is applied. The coatings may provide a reduced coefficient of friction between the coating and a surface of the syringe relative to the coefficient of friction between the uncoated component and the syringe surface. Methods for manufacturing a syringe or syringe component including such coatings, as well as methods for isolating a substance in a syringe from a syringe component, are also disclosed.

A method for producing a resin syringe includes: a preparation step including: preparing a syringe body made of polyolefin, and preparing an ink comprising components including a volatile solvent that contains a dissolving component for dissolving the polyolefin, chlorinated polypropylene having a degree of chlorination in a range of 15 to 30%, a colorant, and a filler; an application step including applying the ink to at least a part of an outer surface of the syringe body, such that at least a part of the outer surface of the syringe body is dissolved by the dissolving component to form a plurality of recessed portions in the outer surface, each of the plurality of recessed portions is filled with at least one of the components of the ink; and a drying step including drying the applied ink to form a printing layer.

A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, a surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness, the inner surface of the barrel having a surface roughness Ra of less than 100 nm.

A method of inserting a lubricant free stopper into a lubricant free syringe barrel or lubricant free cartridge tube is disclosed. The method includes (1) inserting a stopper with a sealing rib into a placement region of a hybrid insertion device, (2) lowering the body of the hybrid insertion device into a syringe barrel or cartridge tube to a position located past the barrel flange or top of the cartridge tube while stablishing a sealable connection with the syringe barrel or cartridge tube, (3) maneuvering the stopper past the distal opening of the hybrid insertion device using an insertion pin and deploying the stopper at a final position within the syringe barrel or cartridge tube under vacuum assistance, (4) fully retracting the insertion pin from the syringe barrel or cartridge tube, and (5) retracting the hybrid insertion device from syringe barrel or cartridge tube. The method is lubricant free or substantially lubricant free. The hybrid insertion device may be electropolished and/or extrude honed.

A medical syringe which is suitable for dispensing and injecting medical foams is described and claimed. The syringe has a standard syringe plunger and barrel arrangement but comprises a flexible annular flange on the inner surface of the barrel. The annular flange extends inwards and forwardly from a base portion, affixed to the inner surface of the barrel to contact the plunger shaft and form a seal. The shape and orientation of the annular flange enables injection of medical foam with reduced sputtering of the syringe contents which make administration of sclerosing foams more controllable.

An article or vessel is described including a vessel surface and a coating set comprising at least one tie coating, at least one barrier coating, and at least one pH protective coating. For example, the coating set can comprise a tie coating, a barrier coating, a pH protective coating and a second barrier coating; and in the presence of a fluid composition, the fluid contacting surface is the barrier coating or layer. The respective coatings can be applied by PECVD of a polysiloxane precursor. Such vessels can have a coated interior portion containing a fluid with a pH of 4 to 8. The barrier coating prevents oxygen from penetrating into the thermoplastic vessel, and the tie coating and pH protective coating together protect the barrier layer from the contents of the vessel. The second barrier coating is comparable to glass surface if needed.

The present disclosure refers to a housing element for a drug delivery device. The housing element comprises longitudinal axis and defines an interior space for receiving components of a drive mechanism of the drug delivery device and at least a portion of a cartridge of the drug delivery device. The housing element comprises an engagement feature for axially constraining the housing element to a cartridge holder of the drug delivery device. In order to constrain the cartridge in the housing element, it further comprises at least one crush web protruding radially inwards into the interior space. The at least one crush web is angled relative to the longitudinal axis of the housing element by at least 3° such that when the cartridge is introduced into the interior space the at least one crush web folds radially outwards.

A needle assembly for medical or surgical use is disclosed, such as for hemodialysis. A representative needle assembly comprises an outer needle assembly and an integral needle tip protector. A representative outer needle assembly comprises: an outer needle comprising: a first lumen; a first aperture with a sharp needle tip at a first distal end of the outer needle; and a second aperture arranged opposite the first aperture. In another embodiment, the outer needle has a longitudinal slot and the integral needle tip protector includes a sliding connector which is slidable in the longitudinal slot. The integral needle tip protector is arranged within the first lumen and moveable between a retracted configuration and an extended configuration, and comprises: a needle tip cover arranged to shield the sharp needle tip in the extended configuration, the needle tip cover having a smooth or beveled distal surface forming a blunt tip.