In one aspect, a self-lubricating component is provided for a pharmaceutical packaging assembly. The self-lubricating component comprises a polymer composition and an effective amount of a lubricating additive such as, for example, boron nitride. In another aspect, a pharmaceutical packaging assembly may be provided having a surface thereof coated with a lubricating composition comprising boron nitride. The pharmaceutical packaging composition may be, for example, a pre-filled syringe comprising a body (barrel) and a plunger assembly.

Pre-loaded syringes for delivering an embolic agent are disclosed herein. Methods related to syringes pre-loaded with an embolic agent are also disclosed.

A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper. The container exhibits a ratio of a break loose force (BLF) relative to a glide force (GF) of BLF/GF≤2 during a break loose and glide force test and a total glide force variation TGFV=GF.sub.max−GF.sub.min measured when the stopper is moved from a start position to its end position is TGFV<2 N.

Medical devices such as medical containers can be formed of glass and annealed which produces a clean device having a low bio-burden, or formed by plastic molding which produces a clean device. The clean devices are immediately transferred to a controlled environment such as a clean room or localized area to avoid the need to maintain cleanliness levels in an entire room. Syringe tip closures can be introduced into the housing assembly, where syringe barrels and tip closures are cleaned with filtered ionized air and the tip closures are coupled to the barrels. The syringe barrels can be filled with a substance and a closure member attached. While still in the housing assembly the syringe barrels can be formed into an array and placed in a clean outer container, which is then closed and sealed.

A pharmaceutical product includes a delivery syringe comprising a plastic receptacle and an oxygen-tight envelope which envelopes the delivery syringe in an oxygen-tight manner, wherein the plastic receptacle is filled with an oxygen-sensitive active pharmaceutical ingredient fluid and an inner surface of the plastic receptacle is siliconized at least in sections.

An embodiment in accordance with the present invention is directed to a device for use as a cryosyringe and a cryo-storage vial. The device includes a first end and a second end and has an outer wall defining a lumen between the first and second ends. Both the first end and the second end include threads configured for attaching a first cap to the first end and a second cap to the second end. The device can also include a syringe plunger adapter, such that the cryo-storage vial is convertible into a cryosyringe to ensure sterility of the contents. Similarly, a luer-lock adapter can be included to further convert the device into a cryosyringe. The device and its components are formed from a cryo-resistant material. The device can therefore withstand liquid nitrogen temperatures necessary to preserve cell viability and be injected without compromising sterility to dispense the cellular therapy.

A slidable rubber material that has an amino-modified interfacial layer that does not affect the compression set. Although the slidable rubber material includes a rubber component such as a butyl rubber or halogenated butyl rubber etc. having the low-compression set, which contains a vulcanization agent such as a nitrogen/sulfur compound or a vulcanizing auxiliary agent, the rubber part is coated with a silicone rubber layer. The slidable rubber material exhibits a slidability and resists the detachment or elution of fine particles from the coating layer. A rubber component and a vulcanization agent; an interfacial modification layer that coats the rubber part and an amino-modified silicone compound is incorporated with surface molecules of the rubber part; and a layer that coats the interfacial modification and contains solid fine particles, an addition-type or condensation-type silicone rubber in which the particles are dispersed, and a curing catalyst for silicone rubber.

A laminated gasket to be inserted in a syringe barrel prevents leakage of a highly permeable liquid drug which may otherwise occur when an inert film of the gasket does not intimately contact an inner wall of the syringe barrel. The laminated gasket has a circumferential surface portion , a liquid contact surface, a bottom surface , and a threaded hole adapted to be in threaded engagement with a distal end portion of a plunger. The threaded hole has an internal thread provided on an inner peripheral surface thereof and including a plurality of periodic thread portions. Provided that an innermost periodic internal thread portion has a diameter Fl, that the other periodic internal thread portions each have a diameter F2 and that a distal one of periodic thread portions of an external thread provided on the distal end portion of the plunger has a diameter D1, a relationship F2>D1>F1 is satisfied.

This disclosure describes devices and methods used to inject or aspirate fluid into or from various regions of the human body, such as the anterior chamber of the eye. The disclosed devices and methods provide improvements over conventional devices and methods in that an operator can perform a procedure using the disclosed device without an assistant. The disclosed devices and methods allow one-handed injection or aspiration of fluid into or from body tissue, and provide means for controlling the volume of injected or aspirated fluid.

Apparatus and methods of assembling apparatus (e.g. a pre-filled syringe). The methods comprising setting a length of a plunger rod of a plunger rod assembly, and fitting the plunger rod assembly to a barrel of the syringe, the barrel having an opening at a forward end thereof and comprising a bung positioned therein and creating a volume between the bung and the opening, the volume at least partially filled with a substance for delivery from the syringe. Setting the length of the plunger rod assembly may comprise at least partially inserting the plunger rod into the barrel such that a forward end of the plunger rod contacts the bung, wherein, after assembly, the length of the plunger rod defines a separation between the bung and the forward end of the plunger rod.