The present invention provides a drug reservoir (1) comprising a reservoir body (2) extending between an outlet end (4) and a proximal end (7), a front piston (8) arranged in a pre-use position within the reservoir body (2) between the outlet end (4) and the proximal end (7), a rear piston (9) arranged within the reservoir body (2) between the front piston (8) and the proximal end (7) a distal chamber (10) defined by the outlet end (4), a first portion of the reservoir body (2), and the front piston (8), the distal chamber (10) holding first contents (18), a proximal chamber (11) defined by the front piston (8), a second portion of the reservoir body (2), and the rear piston (9), the proximal chamber (11) holding second contents (12, 19) comprising a proximal liquid volume (19), and bypass means (3) allowing fluid flow past the front piston (8) in an advanced position of the front piston (8) in the reservoir body (2), wherein the second contents (12, 19) further comprises a proximal gas volume (12) lying within a volume range having a predetermined minimum value.

A syringe having two variable volumes are described herein. The syringe includes a first stopper and a second stopper, the first stopper being connected to a plunger. A first variable volume is disposed between the first stopper and the second stopper and a second variable volume is between the second stopper and a distal end of a barrel of the syringe. A flow path structure is disposed at the distal end of the barrel, the flow path structure extending from the distal end of the barrel along the inner sidewall of the barrel.

Proposed is a syringe for dermis regeneration, the syringe including: an injection unit having a first space therein and being open at a rear end portion, the first space being filled with a liquid or a gas and communicating with the outside; a needle combined with a front end portion of the injection unit and having a space therein, the space communicating with the first space; a liquid supply unit having a first end portion removably combined with the rear end portion, having a second end portion through which a piston moves, and having a space therein, the space being filled with the liquid and communicating with the first space, and the piston being inserted into the liquid supply unit; and a gas injection port passing through a sidewall of the injection unit and communicating with the first space to allow the first space to be filled with the gas.

The present invention provides a two-chamber type combined container-syringe including: a cylinder having a first end portion, a second end portion in an opposite direction of the first end portion, and a bypass portion disposed between the first end portion and the second end portion; a finger grip mounted on the second end portion of the cylinder; a first stopper, a second stopper, and a third stopper that are sequentially disposed from the first end portion toward the second end portion in a space of the cylinder; and a plunger rod that is connected to the third stopper and has a plurality of support ribs provided to come in contact with an inner surface of the finger grip, wherein a space between the first stopper and the second stopper forms a front chamber, a space between the second stopper and the third stopper forms a rear chamber, a first ingredient and a second ingredient are accommodated in the front chamber and the rear chamber, respectively, a length ratio of the front chamber and the rear chamber is in a range of 1.6:1 to 3:1 when the plunger rod is at an initial position which is a state before the front chamber and the rear chamber communicate with each other through the bypass portion, and at the initial position, one or more support ribs are disposed in at least one of the finger grip and a region in the cylinder that is adjacent to the finger grip.

The present disclosure relates generally to the field of drug delivery. In particular, the present disclosure relates to a drug delivery system that includes a sealed and sterile fluid path attached to a drug-loaded container. The disclosure further relates to methods for sterilizing a portion of the drug delivery system without exposing the drug-loaded container to harmful sterilization parameters.

Provided is a pre-filled syringe that can inhibit protein aggregation after long-term storage even when filled with a protein solution formulation having a low non-ionic surfactant concentration. The pre-filled syringe includes: a barrel formed of a resin containing a hydrogenated cycloolefin ring-opened polymer and/or a copolymer of a cycloolefin and a chain olefin; a sealing member sealing a nozzle of the barrel; a gasket housed inside the barrel; and a plunger performing a movement operation of the gasket, and contains a protein solution formulation in a space defined by the sealing member, the gasket, and a region that is part of an inner wall surface of the barrel. The region that is part of the inner wall surface has a water contact angle of 90° or more. The protein solution formulation has a non-ionic surfactant concentration of 0 mg/mL to 0.01 mg/mL.

A processor receives an image of a syringe. After identifying a background and foreground of the image, where the foreground indicates pixels that may be associated with a defect, the processor subtracts the background to generate an updated image with an accentuated foreground. The processor applies a bounding box to a group of pixels in the foreground and inputs the bounding box into a classifier. The classifier outputs a label indicating whether the syringe is defective.

A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

A medical injection system adapted for a single-handed injection, the medical injection device comprising a gas compartment configured to contain a gas, the gas compartment comprising a piston, a reservoir intended to contain a drug composition, the reservoir having a proximal portion and a distal portion provided with a fluid exit configured to receive an injection needle, wherein the piston can move proximally between a distal position defining a first volume of the gas compartment to a proximal position defining a second volume of the gas compartment smaller than the first volume, and wherein the gas compartment is in gas communication with the reservoir in order to force the drug composition through the fluid exit, when the piston is moved proximally.

Provided is a system for calculating design specifications of an administration apparatus which administers an administration object substance to an object region using a high-energy substance as a driving source. An object administration apparatus to be an object of calculation of the design specifications is specified and substance information related to a prescribed administration object substance to be administered in the object administration apparatus is acquired. Region information related to a prescribed object region is acquired, and distribution information related to a distribution state of the prescribed administration object substance is acquired. In addition, based on the respective pieces of acquired information, design specification information related to a configuration of the object administration apparatus including energy information related to a high-energy substance to be used to administer the prescribed administration object substance is calculated. Accordingly, convenience of the administration apparatus is improved.