A system for delivering an injection of a fluid into a void within a subject is disclosed. A barrel extends from a first end to a second end and forms a lumen extending from the first end to the second end. A plug and a floating seal are arranged within the lumen. A hollow needle includes a distal end with an opening for fluid to flow from the lumen. The plug, the barrel and the floating seal include material and dimensions selected based on a threshold flowrate for a fluid arranged within the lumen to: overcome a force opposed to a force being applied to the fluid in the lumen to move the floating seal and the hollow needle into a tissue of the subject, and succumb to the opposing force to displace the fluid through the opening into the void.

A pre-filled syringe includes: a cylindrical container, a front end-side gasket; a rear end-side gasket; an intermediate gasket partitioning an inside of the cylindrical container into a front chamber and a rear chamber; a plunger; a medical drug contained in the front chamber, and a liquid drug contained in the rear chamber. In a state where the plunger is pushed in, a bypass portion included in the cylindrical container faces a groove portion provided in the intermediate gasket, thereby allowing communication between the front chamber and the rear chamber therethrough, so that the medical drug and the liquid drug are mixed, and a liquid mixture is discharged. The pre-filled syringe further includes a movement limiting mechanism for limiting movement of the plunger such that a tail end of the rear end-side gasket does not reach the bypass portion.

The syringe includes a hollow body with at least one free-floating piston and a plunger within the body, with the piston between the plunger and a proximal end of the body. A manifold is provided lateral to the body. The manifold leads to an input/output tip. The manifold includes a front port located between the piston and the proximal end of the body and a rear port spaced from the proximal end of the body. The manifold includes at least one flow path leading from the input/output tip to at least one of the front port and/or the rear port. A first fluid fills a rear chamber distal to the piston and then the manifold is adjusted to fill second fluid into a front chamber proximal of the piston, and then the manifold is adjusted to allow sequential delivery of the second fluid and the first fluid.

Various systems and methods for the pressure-regulated transfer of medical fluids are disclosed. The system can include an adapter assembly that connects with a medical container and with a syringe assembly. The syringe assembly can include a first reservoir and a second reservoir. In various embodiments, when the adapter assembly and the syringe assembly are coupled, the first reservoir and the container can exchange regulating fluid and the second reservoir and the container can exchange medical liquid from the medical container.

A portable auto-injector configured to store a liquid component in a first chamber separately from a dry medication in a second chamber, wherein a first actuation mechanism opens a valve allowing for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

An administration instrument includes an injection button which can be pressed at an angle that is not parallel to a needle with respect to a direction in which the needle is inserted into skin. As a result, it is possible to prevent a force of pressing the injection button from being transmitted in the direction in which the needle is inserted into the skin deeper than initial insertion of the needle, thereby achieving an administration under a stable state.

A medical container, comprising a barrel having an inner surface partially treated with a friction reducing agent, the barrel having at least one substance chamber and wherein the at least one substance chamber defines a portion of the inner surface, which is not treated with the friction reducing agent.

A medical injection system adapted for a single-handed injection, the medical injection device comprising a gas compartment configured to contain a gas, the gas compartment comprising a piston, a reservoir intended to contain a drug composition, the reservoir having a proximal portion and a distal portion provided with a fluid exit configured to receive an injection needle, wherein the piston can move proximally between a distal position defining a first volume of the gas compartment to a proximal position defining a second volume of the gas compartment smaller than the first volume, and wherein the gas compartment is in gas communication with the reservoir in order to force the drug composition through the fluid exit, when the piston is moved proximally.

The present disclosure relates to a stopper assembly configured to be disposed in a barrel of an injection device containing a medicinal fluid. The stopper assembly includes a stopper having a laterally outermost surface configured to be directly engaged with an inner surface of the barrel. The stopper assembly also includes a sealing element coupled to and axially distal relative to the stopper in the barrel. The sealing element having a laterally outermost surface configured to be directly engaged with the inner surface of the barrel and to sealingly isolate the stopper from the medicinal fluid in the barrel. The present disclosure further relates to an injection device including the stopper assembly.

Fluid delivery devices for delivering therapeutic agents are described. More particularly, this disclosure relates to drug reconstitution devices having a plurality of components movable with respect to one another such that an active agent and a solvent can be reconstituted within the device prior to injection. The fluid delivery devices can include a housing, a cartridge holder, a cartridge disposed within the cartridge holder, a button rod, and a foot. The cartridge stores the active agent and the solvent, which are separated by one or more stoppers. The button rod and foot can provide an axial force upon the stopper(s) in the cartridge to inject the fluid once reconstituted. The foot and the button rod can be separate components, thereby enabling the foot to rotate independently with respect to the button rod as the cartridge holder is rotated to reconstitute the therapeutic and prime the device for injection.