Examples herein provide a syringe comprising a fluid reservoir and a male connector comprising a fluid flow channel in fluid communication with the fluid reservoir. The male connector including a male luer having a tapered sealing surface configured to mate with a female tapered surface of a female connector to form a substantially fluid-tight seal. The male luer has a distal tip with a recess defined by a recess surface that is distal to the tapered sealing surface. A water-soluble antimicrobial composition is disposed on the recess surface. The male luer is configured such that, when the male connector is mated with a female connector to form a substantially fluid-tight seal, a cavity is formed between the female tapered surface and the recess surface.

A primary container assembly includes a primary container defining a body having a proximal end defining an opening configured to receive a plunger, a distal end opposite the proximal end and defining an outlet, and a chamber extending from the proximal end to the distal end that is configured to receive a drug. The primary container assembly further comprises a tube extending from a first end that is integrally attached to the distal end of the primary container to a second end opposite the first end, where the tube defines a channel extending from the first end to the second end. The primary container assembly also includes a hollow needle configured to penetrate skin of a patient.

Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

A needle-equipped outer cylinder includes: a needle tube; a joining member comprising: a needle tube accommodation hole that accommodates a proximal end side portion of the needle tube and penetrates the joining member from a distal end of the joining member to a proximal end of the joining member, and a joining outer peripheral portion provided on an outer peripheral portion of the needle tube accommodation hole; and an outer cylinder member comprising: a distal end joint that comprises an inner cavity that receives the joining outer peripheral portion of the joining member from a distal end side, and a projection located at a proximal end portion of the inner cavity and projecting into the inner cavity. The joining member comprises, at a proximal end portion of the joining member, an abutment portion that abuts the projection of the outer cylinder member.

A system includes a flow sensor contained within a flow sensor housing, a base, and a seal. The base houses a controller that generates at least one operation modification signal, and the flow sensor is separable from and mountable onto the base. A bottom surface of the flow sensor housing includes the seal. The seal forms a liquid-tight engagement between the flow sensor housing and the base when the flow sensor is mounted onto the base.

The present invention is directed to an applicator, configured to reversibly attach to a dispensing device, with at least one micropore and a kit for administration of a therapeutic agent. Methods of use of the applicator are also disclosed herein.

Modules for housing electronic and electromechanical medical equipment including a system to measure and record administration of one or more IV medications or fluids for IV administration.

An injection device includes a cylinder having a cavity for receiving a liquid. A passage is connected to the cavity for inflow and/or outflow of the liquid. The passage can be connected to an injection component. A shut-off valve has a valve body and a flexible sealing ring with an opening. The valve body, proceeding from a release position in which the passage is freed, is at least partially movable through the opening of the sealing ring to a blocking position in which the valve body engages behind the opening so that movement of the valve body to the release position is blocked and the passage is sealed off against proximally directed flow. An adapter body is connected to the cylinder. The shut-off valve is arranged at a proximal end of the adapter body and at a distal end of the cylinder. The device can be used in a syringe.

Disclosed is a method of sealing a syringe barrel having a syringe tip with a collar. The syringe tip is sealed with a resilient closure. A tamper evident syringe tip cap comprising a cap member and a sleeve member separated by an annular first breaking line is then pushed over the resilient closure, to couple the proximal end of the sleeve member with the collar. The distal end of the resilient closure is accommodated in the cap member and protrudes beyond the sleeve member. The first breaking line is bridged by a coupling strip. For use of the syringe and providing access to the closure, the first breaking line is broken by pivoting the cap member away. The sleeve member remains coupled to the collar. Further tearing the cap member downward causes breaking a second breaking line provided in the sleeve member, thereby enabling removing the entire syringe tip cap.

A needle and syringe system, wherein a needle head is attached to a syringe assembly. The syringe assembly includes a syringe barrel and a plunger rod with a plunger head. A needle base is affixed to the syringe barrel. A tubular cavity is formed in the needle base and a post extends through the tubular cavity. A needle extends through the post. A spacer is provided. The spacer is displaced into the tubular cavity within the needle base as the plunger head is advanced within the syringe barrel. A protective cover is disposed about the needle base. The spacer moves the protective cover between a first position and a second position as the spacer is displaced into the tubular cavity. As the protective cover moves between positions, the protective cover surrounds the needle and prevents the needle from causing any inadvertent needle stick injuries.