Pre-filled syringes include an elastic and sliding valvular joint acting as a temporary closure to prevent internal chamber(s) from communicating with the outside (or between chambers). The joint includes two discoid cooperative elements: an elastic discoid cap and a sliding receiving discoid seat that has a central passage tube. The cap includes an elastic base from which a compact closing cylinder protrudes. The closing cylinder has a distal area with a plurality of longitudinal grooves. The cap can: (a) half-fit the central tube of the receiving discoid seat, which will allow the communication of fluid through the plurality of grooves, and (b) seal the chamber by completely fitting the central tube of the receiving discoid seat. Accordingly, the half-fit position allows the lyophilization of contents of the syringe.

Apparatus and methods for medicament delivery. The apparatus may include, and the methods may involve, a delivery device for delivering a target amount of the medicament from a distal end of the device. The device may include a rod for moving a plunger that discharges the medicament from the distal end. The device may avoid or reduce deformation of the plunger during the discharge. The plunger motion may be stopped by detent that interacts with the rod. The apparatus and the methods may provide an operator indication of progress of stages of operation. The device may feature triggers corresponding to stages of medicament displacement from the device, such as pre-delivery stages, including priming.

Mixing/administration systems and methods for preparing an agent for administration to an individual are disclosed. Caps may be included as part of the system, which may include compositions comprising at least one of a cleansing, antiseptic, antimicrobial, or disinfectant agent. The caps may additionally be included that may be used for hemostasis at an injection site. Packaging and/or the mixing/administration system within it may include a tracking mechanism for data tracking regarding many different aspects of the system, including aspects of manufacture and administration.

An elastic and sliding valvular joint for pre-filled syringes, which comprises a single chamber with an injectable product or two chambers that contain isolated products to be mixed before the injection is described. The valvular joint acts as a temporary closure, which prevents the internal chamber from communicating with the outside, or between both internal chambers. The joint comprises two discoid cooperative elements arranged on the syringe and with its edge against the internal surface: an elastic discoid plug and a sliding receiving discoid seat. The receiving discoid seat includes a central passage tube facing the hollow cylinder, and the elastic base of the plug fits in a removable manner inside a cylindrical cavity of the opening of the central passage tube of the seat.

A dose indicating mechanism for a drug delivery device is configured for delivery of a medicament contained in a single medicament cartridge, the medicament comprising at least a first drug and a second drug, wherein the dose indicating mechanism comprises a body, a dose dial component configured to move relative to the body during dose setting and a first dose indicator configured to display a set dose of the medicament, the first drug, or the medicament and the first drug depending on displacement of the dose dial component during the dose setting. In order to provide a user with further information, a second dose indicator is provided that is configured to display a set dose of the second drug during the dose setting. The disclosure is also directed to a respective drug delivery device.

A portable auto-injector configured to store a dry medication separately from a liquid component, wherein removal of a cap operates a first actuation mechanism which opens a valve between a first and second chamber that are slidably movable relative to each other and thus allows for the initiation of a mixing step prior to injection. An extendable needle guard is provided over the delivery assembly which prevents premature injection as well as inadvertent sticks or other cross contamination of a needle. The needle guard can also form part of a secondary trigger mechanism which injects the mixed components after the mixing stage is complete.

A dual chamber syringe, comprising a syringe barrel having a forward end, a rearward end and at least one bypass protrusion arranged along the longitudinal extent of the syringe barrel; a finger grip element coupled to the rearward end of the syringe barrel, the finger grip comprises at least one protrusion extending radially inwardly from an inner surface thereof; a plunger rod operatively coupled with the finger grip element; a guiding track is formed on the plunger rod and comprises a helical track portion and a longitudinal track portion; and wherein upon relative displacement of the plunger rod and said finger grip element, the at least one protrusion is guided along the guiding track.

Disclosed is a double chamber container. The first chamber comprises a stopper coupled to a first end and a cover coupled to a second end. The second chamber comprises a plunger coupled to one end and an open second end. The first chamber is coupled to the second chamber such that the first end of the first chamber is coupled to the second end of the second chamber.

Compact, light-weight, handheld printer devices are capable of delivering multi-part materials in mixed form, with controllable dwell-time within the device to allow for a desired amount of physical mixing and chemical cross-linking, while also allowing for deposition of the material directly onto a deposition site. A pen-style printer having a slim but elongated form factor is particularly suitable for depositing biomaterials directly onto a surgical site in the throat. The device may be configured to receive and dispense materials directly from conventional syringes. The printer device may be configured for dispensing and mixing materials having two or more component parts, and may include a leadscrew mechanism providing mechanical advantage, for dispensing higher-viscosity materials, and/or an enhanced degree of precision in dispensing a quantity of material. The mixing time and quantities can be controlled by varying one or more of syringe size and/or injector passage size and mixing chamber length.

A method for generating microbubbles may include providing a syringe having a barrel defining an interior volume, a plunger, a tip and a check valve assembly. The check valve assembly may have an inlet port; a check valve that is configured to open when the plunger is drawn back by a user; and a nozzle in fluid communication with the interior volume and, when the check valve is open, in fluid communication with the inlet port. The method may include drawing liquid into the interior volume; removing a seal from the inlet port and drawing gas adjacent the inlet ports into the interior volume to form microbubbles in the liquid already drawn in; coupling the tip to an intravenous line associated with a patient undergoing a bubble study; and depressing the plunger to force the liquid and the formed microbubbles into the intravenous line.