A hybrid blunt cannula with puncture needle assembly that includes a barrel body having a sidewall, two opposing ends, defining and enclosing a barrel channel, and defining a button translation channel through the sidewall of the barrel body, a hub translatably disposed within the barrel channel, an outer cannula member with one end disposed within the hub and a second end for contacting an individual's skin, defining an eye thereon, an inner needle member of a substantially rigid material disposed within the outer cannula member and having a second inner needle free end that is of a sharp configuration, and having a button translatably coupled to the hub, disposed within the button translation channel, and operably configured to modulate the hub and outer cannular member independent of the inner needle member to cause the inner needle to translate through the second cannular end to puncture the individual's skin.

A system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes an injectable fluid disposed in the syringe interior. The system further includes a finger flange coupled to the syringe flange. Moreover, the system includes a stopper member disposed in the syringe interior. In addition, the system includes a plunger ratchet member coupled to the stopper member. The system also includes a plunger tube disposed coaxially around at least a portion of the plunger ratchet member and operatively coupled thereto.

The present disclosure relates to cannula systems for delivery of a therapeutic agent to parenchymal tissue of a target subject. In certain embodiments, the cannula system is for delivery of a therapeutic agent to parenchymal tissue in the spine of a target subject. In certain embodiments, the cannula system includes a cannula positioning guide (CPG) useful in the delivery of a therapeutic agent to a localized target tissue of a subject. The guide may be used in a surgical suite or during a surgical procedure.

A transfer device for living organisms is used for placing an object in a living organism. The transfer device for living organisms includes a tubular needle extending in one direction, and a pushing member located inside the needle. The needle is configured to capture an object therein from an opening at a tip of the needle. The pushing member is configured to be movable relative to the needle from inside the needle toward the opening.

A two piece adapter for extrusion of cylindrical core-shell structures using conventional biomedical needles includes first and second adapter pieces. The first adapter piece includes first and second (core and shell) inlet ports. The core inlet port leads directly to a male Luer fitting attachable to a core needle and surrounded by a threaded chamber. The shell inlet port is led, via a side chamber, into the side of the threaded chamber. The second adapter piece attaches to the bottom of the threaded chamber and is configured to attach to a shell needle, so that the shaft of the core needle sits inside the shaft of the shell needle.

In one embodiment, a system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes an injectable fluid disposed in the syringe interior. The system further includes a stopper member disposed in the syringe interior. Moreover, the system includes a plunger member coupled to the stopper member. In addition, the system includes a finger flange removably coupled to the syringe flange, the finger flange including a proximally directed screw. The system also includes a rotatable member disposed on the proximally directed screw, the rotatable member defining a rotatable member opening through which the plunger member is disposed and having an elastic latch disposed adjacent the rotatable member opening.

The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.

Disclosed is a cannula system having a rigid cannula, a cannula assembly and an insertion assembly. The rigid cannula is connected to the cannula assembly. The cannula assembly has a septum mounted to a mounting structure of the cannula assembly, a connecting structure for reversibly or irreversibly connecting the cannula assembly to a cannula assembly holder, a cavity being at least partially formed by the septum. The rigid cannula is in fluidic communication with the cavity. Furthermore, the insertion assembly has a rigid needle at least partially penetrating the septum and an attachment structure for reversibly attaching the insertion assembly to the cannula assembly.

In one embodiment, a system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes an injectable fluid disposed in the syringe interior. The system further includes a stopper member disposed in the syringe interior. Moreover, the system includes a plunger member coupled to the stopper member. In addition, the system includes a finger flange removably coupled to the syringe flange, the finger flange including a proximally directed screw. The system also includes a rotatable member disposed on the proximally directed screw, the rotatable member defining a rotatable member opening through which the plunger member is disposed and having an elastic latch disposed adjacent the rotatable member opening.

Disclosed here are syringe assemblies that include a modified syringe tip to penetrate a subject to obtain or administer a substance. The syringe system consists of a syringe body with or without a modified syringe tip with a standard or modified plunger. The modified syringe tip or modified plunger protrusion can penetrate a subject, such as the skin of a patient or a membrane on sealing a container containing medicine, or a seal of an empty vial.