Embodiments relate to a cannula that is provided for delivering a substance, such as a medicine (e.g., insulin) to a patient, where the cannula has reduced likelihood of kinking or occlusions when implanted in a patient. The cannula may have a reduced number of stress concentrations along its length, an angled tip and/or a curve in its length. The cannula may include other designs to reduce kinking, such as internal ribbing and/or a slit along its wall.

An approach is provided for delivering therapeutic materials to an intervertebral disc via a sub-ligamentous space. The approach includes positioning a tool at an interface of a longitudinal ligament and an outer surface of the intervertebral disc, in which the interface is the sub-ligamentous space. The tool may include a first needle and a second needle housed within the first needle. An insertion end of the first needle may include a shallow beveled end. The approach includes inserting the insertion end of the first needle into the sub-ligamentous space. The approach includes deploying the second needle from within the first needle into at least one of an annulus and a nucleus of the intervertebral disc. The approach includes delivering the therapeutic materials to the at least one of the annulus and the nucleus.

Syringe assemblies including a syringe pre-equipped with an integral liquid drug administration device for enabling administration of liquid drug contents and a drug vial adapter for telescopic mounting on a drug vial containing liquid drug contents. The drug vial adapter is initially mounted on the syringe and is intended to be manually detached therefrom to expose the integral liquid drug administration device. The syringe includes a flow control member having an initial flow path position for enabling filling the syringe with liquid drug contents from the drug vial and a final flow path position for enabling administration of liquid drug contents. Detachment of the drug vial adapter from the syringe urges the flow control member from its initial flow path position to its final flow path position.

A cap assembly for a drug delivery device is described comprising a cap, and a clip element which is configured to be attached to the cap, the clip element comprising a first component, and a second component, wherein the first component is at least partly received by the second component, wherein the first component and the second component are firmly connected to one another, and wherein the connection between the first component and the second component is the means by which the second component is attached to the cap. Moreover, a method for assembling a cap assembly is described.

The present invention provides a drug composition comprising particles comprising a biodegradable or bioerodable polymer and a drug, a soluble, biodegradable or bioerodible excipient, a bulking agent and a reconstitution aid. The invention also provides a pharmaceutical formulation and a unit dosage form of the pharmaceutical formulation. The invention provides methods of treatment of a disease or condition accordingly. The invention also provides a drug composition for use in a cannulation device.

The present invention provides a cannulation device for administering an active agent containing composition into the eye. The invention provides methods of treatment of an ocular disease or condition accordingly. The invention also provides a method for injection of a material accordingly.

An injection needle has an opening at a distal end thereof the injection needle and defines a hole. An optical fiber is configured to output a light from a light source and inserted in the hole. The optical fiber has a distal end positioned on an inner side of the opening. A protector is configured to transmit the light and is positioned further towards an opening side of the injection needle than the distal end. The protector is configured to prevent adherence of tissue to the optical fiber. The light emitted from the optical fiber is configured to irradiated onto a treatment target in a state in which the injection needle is inserted into skin, the distal end is positioned on an inner side of the opening, and the protector is positioned further towards the opening side of the injection needle than the distal end.

In one embodiment, a system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes an injectable fluid disposed in the syringe interior. The system further includes a stopper member disposed in the syringe interior. Moreover, the system includes a plunger member coupled to the stopper member. In addition, the system includes a finger flange removably coupled to the syringe flange, the finger flange including a proximally directed screw. The system also includes a rotatable member disposed on the proximally directed screw, the rotatable member defining a rotatable member opening through which the plunger member is disposed and having an elastic latch disposed adjacent the rotatable member opening.

A system for injecting includes a syringe body having proximal and distal ends, a syringe interior, and a syringe flange at the proximal end thereof. The system also includes an injectable fluid disposed in the syringe interior. The system further includes a finger flange coupled to the syringe flange. Moreover, the system includes a stopper member disposed in the syringe interior. In addition, the system includes a plunger ratchet member coupled to the stopper member. The system also includes a plunger tube disposed coaxially around at least a portion of the plunger ratchet member and operatively coupled thereto.

An epidural needle assembly including an epidural needle assembly and an injection needle assembly. The injection needle assembly is slidably mounted on the needle of the epidural needle assembly between extended and retracted positions. The injection needle assembly includes an injection hub having an injection needle secured thereto which extends forwardly therefrom. When the injection needle assembly is in its retracted position, the forward end of the injection needle is positioned rearwardly of the forward end of the epidural needle. When the injection needle assembly is in its extended position, the forward end of the injection needle is positioned forwardly of the forward end of the epidural needle. When in its extended position, the injection needle is able to create a hole in the skin of a person or animal to permit the epidural needle to be inserted therein.